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Mechanism of Xiaozheng Zhitong Paste in Alleviating Bone Cancer Pain by Regulating Microglial Pyroptosis Based on PINK1/Parkin/NLRP3 Signaling Pathway
更新时间：2026-02-03

    • Mechanism of Xiaozheng Zhitong Paste in Alleviating Bone Cancer Pain by Regulating Microglial Pyroptosis Based on PINK1/Parkin/NLRP3 Signaling Pathway

    • “The latest research has found that the XZP formula for relieving symptoms and pain significantly inhibits astrocyte pyroptosis by regulating the PINK1/Parkin mediated mitochondrial autophagy NLRP3 inflammasome pathway, effectively alleviating bone cancer pain and providing a new mechanism basis for related treatments.”
    • Chinese Journal of Experimental Traditional Medical Formulae   Vol. 32, Issue 5, Pages: 80-90(2026)

    • DOI：10.13422/j.cnki.syfjx.20251932    

      CLC： R277;R285;R289

    • Received：18 August 2025，

      Revised：2025-10-07，

      Accepted：13 October 2025，

      Published Online：22 October 2025，

      Published：05 March 2026

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  • WANG Lingyun,ZHENG Guangda,SHANG Lu,et al.Mechanism of Xiaozheng Zhitong Paste in Alleviating Bone Cancer Pain by Regulating Microglial Pyroptosis Based on PINK1/Parkin/NLRP3 Signaling Pathway[J].Chinese Journal of Experimental Traditional Medical Formulae,2026,32(05):80-90. DOI： 10.13422/j.cnki.syfjx.20251932.

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WANG Lingyun
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Related Institution

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