References
- 1.DE BANDT J P,COUMOUL X,BAROUKI R.Branched-chain amino acids and insulin resistance,from protein supply to diet-induced obesity[J].Nutrients,2022,15(1):68.
- 2.WHITE P J,MCGARRAH R W,HERMAN M A,et al.Insulin action,type 2 diabetes,and branched-chain amino acids:A two-way street[J].Mol Metab,2021,52:101261.
- 3.ZHANG X H,ZHANG S Y,LI L.Amino acid metabolic reprogramming in tumorigenesis and development[J].Chin J Biochem Mol Biol,2023,39(2):174-188.
- 4.GAR C,ROTTENKOLBER M,PREHN C,et al.Serum and plasma amino acids as markers of prediabetes,insulin resistance,and incident diabetes[J].Crit Rev Clin Lab Sci,2018,55(1):21-32.
- 5.LIN L,NI Q,PANG J L,et al.Therapeutic efficacy evaluation by a randomized controlled clinical research on traditional Chinese medical formulas,with herb modification according to syndrome differentiation,in the treatment of 200 type 2 diabetic patients[J].J Med Res,2013,42(2):102-107.
- 6.BU X W,HAO X H,ZHANG M Z,et al.Mechanism of Qingrun formula in improving hepatic insulin resistance of rats with type 2 diabetes mellitus based on high-throughput sequencing[J].World Chin Med,2024,19(11):1599-1607,1613
- 7.QIU ZL,WANG Q H,SUN F H,et al.Effect of Qingrun formula on SIRT/NF-κB signal pathway in liver of diabetic rats[J].China Med Herald,2018,15(28):4-7,12
- 8.QIU Z L,WANG Q H,SUN F H,et al.Effect of Qingrunfang on signal pathway of PI3K/Akt/mTOR in liver of diabetic rats[J].J Med Res,2018,47(12):37-40,45.
- 9.WANG Z.Investigate on the mechanism of Qingrun formula to improve hepatic insulin resistance in type 2 diabetes mellitus based on miR-34a regulating SIRT1/NF-κB signaling pathway[D].Beijing:China Academy of Chinese Medical Sciences,2020.
- 10.YUDHANI R D,SARI Y,NUGRAHANINGSIH D,et al.In vitro insulin resistance model:A recent update[J].J Obes,2023,2023:1964732.
- 11.LIN X L,LI Y,GUO M Q,et al.Berberine promotes expression of AQP4 in astrocytes by regulating production of miR-383-5p in HepG2 cell-derived exosomes under insulin resistance[J].China J Chin Mater Med,2025,50(3):768-775.
- 12.LI X L,HE S M,ZHU Y,et al.Establishment and identify of HepG2 cells model of insulin resistance[J].Chin J Exp Tradit Med Form,2013,19(5):203-207.
- 13.YANG S,XU J P.Effect of oleuropein on insulin signal transduction in insulin-resistant HepG2 hepatocytes[J].Chin J Exp Tradit Med Form,2018,24(20):164-168.
- 14.LI D F,FAN J L,DU L,et al.Glabridin ameliorates insulin resistance by regulating ERK/IRS-1 and PI3K/Akt signaling pathways in HepG2 cells[J].Chin Tradit Herb Drugs,2022,53(24):7751-7762.
- 15.XUE L,SHI Y.Effects of Yitangkang on glucose consumption and IRS-2/PI3K/Akt signaling pathway in IR-HepG2 cells[J].Lishizhen Med Mater Med Res,2022,33(10):2374-2377.
- 16.WEI N Q,HAO E W,XIAN H M,et al.Molecular mechanism of Gynura divaricata on insulin resistance in HepG2 cells[J].Chin J Exp Tradit Med Form,2018,24(2):110-115.
- 17.PANG X J,LU L L,LI D W,et al.Effect of total flavonoids from Bidens pilosa on insulin resistance in HepG2 cells[J].China Pharm,2022,33(8):968-974.
- 18.LIN L.Modern traditional Chinese medicine diabetes science[M].Beijing:People's Medical Publishing House,2008.
- 19.GIESBERTZ P,DANIEL H.Branched-chain amino acids as biomarkers in diabetes[J].Curr Opin Clin Nutr Metab Care,2016,19(1):48-54.
- 20.CUI L,LI Z,LIU X,et al.Association between serum branched chain amino acids,mammalian target of rapamycin levels and the risk of gestational diabetes mellitus:A 1∶1 matched case control study[J].BMC Pregnancy Childbirth,2024,24(1):633.
- 21.ZHAO X,GANG X,LIU Y,et al.Using metabolomic profiles as biomarkers for insulin resistance in childhood obesity: A systematic review[J].J Diabetes Res,2016,2016:8160545.
- 22.JANG C,OH S F,WADA S,et al.A branched-chain amino acid metabolite drives vascular fatty acid transport and causes insulin resistance[J].Nat Med,2016,22(4):421-426.
- 23.HOLEČEK M.Branched-chain amino acids in health and disease:Metabolism,alterations in blood plasma,and as supplements[J].Nutr Metab(Lond),2018,15:33.
- 24.MENNI C,FAUMAN E,ERTE I,et al.Biomarkers for type 2 diabetes and impaired fasting glucose using a nontargeted metabolomics approach[J].Diabetes,2013,62(12):4270-4276.
- 25.MANN G,ADEGOKE O.Effects of ketoisocaproic acid and inflammation on glucose transport in muscle cells[J].Physiol Rep,2021,9(1):e14673.
- 26.BISWAS D,DAO K T,MERCER A,et al.Branched-chain ketoacid overload inhibits insulin action in the muscle[J].J Biol Chem,2020,295(46):15597-15621.
- 27.WäLCHLI M,BERNEISER K,MANGIA F,et al.Regulation of human mTOR complexes by DEPTOR[J].Elife,2021,10:e70871.
- 28.UM S H,D'ALESSIO D,THOMAS G.Nutrient overload,insulin resistance,and ribosomal protein S6 kinase 1,S6K1[J].Cell Metab,2006,3(6):393-402.
- 29.DÜVEL K,YECIES J L,MENON S,et al.Activation of a metabolic gene regulatory network downstream of mTOR complex 1[J].Mol Cell,2010,39(2):171-183.
- 30.FERNANDES S A,ANGELIDAKI D D,NÜCHEL J,et al.Spatial and functional separation of mTORC1 signalling in response to different amino acid sources[J].Nat Cell Biol,2024,26(11):1918-1933.
- 31.QUAN S Y,NAN X M,JIANG L S,et al.Research progress on animal amino acid transport and sensing systems[J].Chin J Anim Nutr,2018,30(10):3810-3817.
- 32.YE Y Y,HUANG Y J,YIN Y L,et al.Mechanism of mTORC1 and GCN2 in regulating development,differentiation,and function of immune cells[J].Sci China Life Sci,2023,53(7):1012-1020.
- 33.BISWAS D,DUFFLEY L,PULINILKUNNIL T.Role of branched-chain amino acid-catabolizing enzymes in intertissue signaling,metabolic remodeling,and energy homeostasis[J].FASEB J,2019,33(8):8711-8731.
- 34.SHULMAN G I.Cellular mechanisms of insulin resistance[J].J Clin Invest,2000,106(2):171-176
- 35.WHITE P J,NEWGARD C B.Branched-chain amino acids in disease[J].Science,2019,363(6427):582-583.
- 36.WHITE P J,MCGARRAH R W,GRIMSRUD P A,et al.The BCKDH kinase and phosphatase integrate BCAA and lipid metabolism via regulation of ATP-citrate lyase[J].Cell Metab,2018,27(6):1281-1293,e7.
- 37.ZHOU M,SHAO J,WU C Y,et al.Targeting BCAA catabolism to treat obesity-associated insulin resistance[J].Diabetes,2019,68(9):1730-1746.
- 38.ZHOU F,SHENG C,MA X,et al.BCKDH kinase promotes hepatic gluconeogenesis independent of BCKDHA[J].Cell Death Dis,2024,15(10):736.


