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Progrès de la recherche sur la régulation du stress du réticulum endoplasmique par la médecine traditionnelle chinoise dans le traitement de la rectocolite hémorragique

  • role： First author第一作者
  • Affiliation：

    Hubei University of Chinese Medicine，Wuhan 430065，China

  • Email：yankeqiu1996@163.com
  • Introduction：颜克秋，在读博士，从事中医药防治肛肠疾病的研究，E-mail：yankeqiu1996@163.com
YAN Keqiu1,  
  • Affiliation：

    Hubei Provincial Hospital of Traditional Chinese Medicine，Wuhan 430061，China

    Affiliated Hospital of Hubei University of Chinese Medicine，Wuhan 430061，China

    Hubei Provincial Institute of Traditional Chinese Medicine，Wuhan 430061，China

ZHANG Xiaoyu234,  
  • Affiliation：

    Hubei Provincial Hospital of Traditional Chinese Medicine，Wuhan 430061，China

    Affiliated Hospital of Hubei University of Chinese Medicine，Wuhan 430061，China

    Hubei Provincial Institute of Traditional Chinese Medicine，Wuhan 430061，China

SUN Guangjun234,  
  • role： Corresponding author通信作者
  • Affiliation：

    Hubei University of Chinese Medicine，Wuhan 430065，China

    Hubei Provincial Hospital of Traditional Chinese Medicine，Wuhan 430061，China

    Affiliated Hospital of Hubei University of Chinese Medicine，Wuhan 430061，China

    Hubei Provincial Institute of Traditional Chinese Medicine，Wuhan 430061，China

  • Email：hb20190101@126.com
  • Introduction：林爱珍，博士，主任医师，从事中医药防治肛肠疾病的研究，E-mail：hb20190101@126.com
LIN Aizhen1234*

résumé

La rectocolite hémorragique (RCH) est une maladie inflammatoire chronique et récidivante de l'intestin, touchant principalement la couche muqueuse du rectum et du côlon, dont le mécanisme pathogénique est complexe et pas encore complètement élucidé. Le stress du réticulum endoplasmique (SRE) joue un rôle clé dans la réponse cellulaire au stress externe et le maintien de l'homéostasie, son activation anormale étant étroitement liée au développement de diverses maladies inflammatoires, en particulier dans la progression pathologique de la RCH. Le SRE maintient l'homéostasie cellulaire en activant la réponse aux protéines non repliées (UPR), mais lorsque le stress est prolongé ou excessif, l'UPR ne peut atténuer ce stress, conduisant à la mort des cellules épithéliales intestinales et aggravant la progression pathologique de la RCH. La régulation du SRE peut être une cible clé dans la prévention et le traitement de la RCH, c'est également un sujet de recherche actuel. La médecine traditionnelle chinoise présente une efficacité remarquable dans la régulation du SRE, via des actions multi-cibles et multi-voies, démontrant des avantages thérapeutiques uniques. Des études récentes ont confirmé que la médecine traditionnelle chinoise peut atténuer le SRE, inhiber l'apoptose, moduler l'autophagie, réduire la réponse inflammatoire et maintenir la fonction de la barrière intestinale pour prévenir et traiter la RCH. Cet article passe en revue la relation entre le SRE et la RCH ainsi que l'intervention de la médecine traditionnelle chinoise dans le traitement de la RCH par la régulation du SRE, afin de fournir de nouvelles idées et méthodes thérapeutiques.

mots-clés

médecine traditionnelle chinoise;rectocolite hémorragique;stress du réticulum endoplasmique;apoptose;autophagie

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