References
- 1.TORRES A,CILLONIZ C,NIEDERMAN M S,et al.Pneumonia[J].Nat Rev Dis Primers,2021,7(1):25.
- 2.GBD 2021 Causes of Death Collaborators.Global burden of 288 causes of death and life expectancy decomposition in 204 countries and territories and 811 subnational locations,1990-2021:A systematic analysis for the Global Burden of Disease Study 2021[J].Lancet,2024,403(10440):2100-2132.
- 3.OLIVEIRA E SILVA P G,CERQUEIRA BATISTA FILHO L A,ISMAEL P F,et al.Community-acquired pneumonia:Epidemiology,diagnosis,prognostic severity scales,and new therapeutic options[J].Medwave,2023,23 (11):e2719.
- 4.GUO A,ZHANG S,FENG J H,et al.To explore the rehabilitation practice of integtated traditional Chinese and Western medicine for COVID-19 from the new understanding of the course of pneumonia[J].Tianjin J Tradit Chin Med,2022,39(7):841-845.
- 5.STOTTS C,CORRALES-MEDINA V F,RAYNER K J.Pneumonia-induced inflammation,resolution and cardiovascular disease:Causes,consequences and clinical opportunities[J].Circ Res,2023,132 (6):751-774.
- 6.CORRALES-MEDINA V F,DEKEMP R A,Chirinos J A,et al.Persistent lung inflammation after clinical resolution of community-acquired pneumonia as measured by 18FDG-PET/CT imaging[J].Chest,2021,160(2):446-453.
- 7.YENDE S,D'ANGELO G,MAYR F,et al.Elevated hemostasis markers after pneumonia increases one-year risk of all-cause and cardiovascular deaths[J].PLoS One,2011,6 (8):e22847.
- 8.HU F F,ZHAO Y,LI M H,et al.Adverse effects of long COVID and its countermeasures:A review[J].Chin J Pub Health,2022,38(9):1229-1232.
- 9.CHEN J,LIU X D,ZHANG S.Analysis of the connotation of traditional chinese medicine "Preventive Treatment" and exploration of development strategies in the new era[J].Lishizhen Med Mater Med Res,2021,32(7):1701-1703.
- 10.LI J S,WANG M H.Strategies and practice of traditional Chinese medicine for prevention and treatment of community-acquired pneumonia based on stages and severity[J].J Tradit Chin Med,2024,65(16):1662-1666.
- 11.ZHOU J P,WANG X P.Analysis on view of combining pathogenic factors in Huangdi Neijing[J].China J Tradit Chin Med Pharm,2021,36(9):5233-5236.
- 12.BAO L Y.Studies on onset theory about combination of pathogenic factors in Canon[D].Jinan:Shandong University of Traditional Chinese Medicine,2018.
- 13.XIONG Y,MOU F Z.Origin and application of TCM thought of "treatment of the pro-disease"[J].Acta Chin Med,2017,32(10):1931-1933.
- 14.LI Z H,WANG Y L.Make textual criticisms and explanations of ci(疵),chai(瘥),fei(痱) in Er Ya connected with Commentaries on ancient disease names and syndrome[J].Jilin Journal of Chinese Medicine,2016,36(3):310-315.
- 15.HUANG Q S,AN X,XIE C G,et al.Traditional Chinese medicine treatment of nucleic acid recurrence in patients with COVID-19 is based on the theory of "disease recurrence caused by overwork after recovery" in Shanghan Lun[J].Pharmacol Clin Chin Mater Med,2020,36(2):15-17.
- 16.SHI W J,YU X Y,KOU L H,et al.Clinical application of traditional Chinese medicine aftercare thinking[J].China J Tradit Chin Med Pharm,2023,38(4):1667-1670.
- 17.KE L Z,LUO L,WANG D X,et al.On the guiding role of theory in preventive treatment of disease “preventing an attack of an old disease”of tumor recurrence and metastasis[J].J Guizhou Univ Tradit Chin Med,2015,37(2):1-5.
- 18.Anonymous.Diagnostic basis,syndrome classification and curative effect evaluation standard of wind-warm disease with lung heat:The standard of TCM internal medicine diagnosis and curative effect(ZY/T001.1-94)[J].J Liaoning Univ Tradit Chin Med,2013,15(4):7.
- 19.HUANG J H,BAI S L,LIU R.Discussion on TCM treatment of pulmonary diseases based on the theory of "Qi and blood"[J].Shaanxi J Tradit Chin Med,2023,44(4):483-486.
- 20.FENG J H,LIU N F,YANG S,et al.A Clinical efficacy study of Fuzheng Jiedu method in the treatment of community-acquired pneumonia based on "real world"[J].Lishizhen Med Mater Med Res,2020,31(1):121-124.
- 21.LI M F,FENG J H,HUANG Y H,et al.Idea for preventing recurrence of pneumonia by invigorating Qi and activating blood circulation method based on regulation of immune inflammation and microvascular damage[J].Liaoning J Tradit Chin Med,2024,51(8):45-47.
- 22.DARDEN D B,KELLY L S,FENNER B P,et al.Dysregulated immunity and immunotherapy after sepsis[J].J Clin Med,2021,10 (8):1742.
- 23.ZHANG W Z,WANG Z B.Research progress on the dyshomeostasis of effector T cell subsets related to immunosuppression in sepsis[J].Chin Critic Care Med,2022,34(1):95-99.
- 24.ZHANG Y C,YANG R L.Progress in immune disorders,immune monitoring and immunotherapy of severe infections[J].Nation Med J China,2016,96(21):1708-1712.
- 25.LUAN Z Y,WANG H X,PENG X,et al.To explore immune-inflammation mechanism of viral pneumonia and TCM treatment based on theory of "healthy Qi and pathogenic Qi"[J].Chin J Exp Tradit Med Form,2025,31(2):239-247.
- 26.LIANG X H.The study on the relationship between the constitution typesof traditional Chinese medicine and related immune function with the recovery of pneumonia in children[D].Guangzhou:Guangzhou University of Chinese Medicine,2010.
- 27.LI Q,ZHANG H,DENG S Y,et al.Comparison of the expression and morphological characteristics of peripheral blood lymphocyte subsets in patients with positive recovery and negative patients during COVID-19 recovery period[J].Chongqing Med J,2020,49(19):3151-3155.
- 28.JIA Y T,LI X Q.Risk factors for respiratory tract infections in children during recovery stage[J].Chin J Nosocomiol,2014,24(14):3603-3604,3618.
- 29.GENG H J,XIE Y M.Discussion on the mechanism of immune function regulation of traditional Chinese medicine in convalescent and discharged patients with new coronavirus pneumonia[J].World Sci Technol Mod Tradit Chin Med,2021,23(2):482-487.
- 30.CHEN O L,WANG Z L.Research progress of microinflammatory state and disease severity in patients with chronic obstructive pulmonary disease[J].J Clin Med Pract,2024,28(6):139-142,148.
- 31.LUO Y L,ZHOU X T,WEI B J,et al.Understanding of inflammatory microenvironment and malignant transformation of inflammation in traditional Chinese medicine[J].Lishizhen Med Mater Med Res,2022,33(8):1966-1968.
- 32.MENG J W,SUI G Y,JIA L Q.Exploring the relationship between endothelial cell homeostasis and pan-vascular diseases based on the "Ying in the vessels" theory.[J].Lishizhen Med Mater Med Res,2023,34(3):655-657.
- 33.SHAO S S,YIN H M,YANG J L,et al.Protective effect of tanshinone ⅡA on pulmonary microvascular endothelial cell injury in sepsis[J].J Emerg Tradit Chin Med,2024,33(4):591-594,624.
- 34.CAO J,QIN J M,XUE W Z.Recent advances in the pathogenesis of coronary microvascular disease:The role of inflammatory reactions[J].Med J Peking Union Med Coll Hos,2022,13(6):1057-1063.
- 35.CHIOH F W,FONG S W,YOUNG B E,et al.Convalescent COVID-19 patients are susceptible to endothelial dysfunction due to persistent immune activation[J].Elife,2021,10:e64909.
- 36.QI P,ZHU H Y.Research progress of long-COVID related cardiovascular disease[J].Chin J Nosocomiol,2024,34(8):1276-1280.
- 37.OIKONOMOU E,SOUVALIOTIS N,LAMPSAS S,et al.Endothelial dysfunction in acute and long standing COVID-19:A prospective cohort study[J].Vascul Pharmacol,2022,144:106975.
- 38.WU Y,LEI Y,XIU C K,et al.Advances in research on the protective effect of Yiqi Huoxue method on vascular injury[J].J Basic Chin Med,2021,27(5):882-886.
- 39.CAI S Q,WANG X,SHANG M Y,et al."Efficacy theory" may help to explain characteristic advantages of traditional Chinese medicines[J].China J Chin Mater Med,2015,40(17):3435-3443.
- 40.WANG B H,SHI S F,ZHANG X N.Exploration on mechanism of Futu Shengjin rehabilitation formula in regulating immune function during COVID-19 convalescence based on the network pharmacology[J].J Nanjing Univ Tradit Chin Med,2021,37(1):91-95.
- 41.SHI S F,FANG Z Y,XIONG K,et al.Clinical observation of the rehabilitation formula for banking up earth to generate metal in treating COVID-19 patients with deficiency of lung and spleen syndrome in the recovery stage[J].J Nanjing Univ Tradit Chin Med,2020,36(3):281-285.
- 42.CHEN H,QIAO M,ZHU J H,et al.Effect of Feikang Yangyin granule on pulmonary disease in convalescence based on immune regulation[J].J Pract Tradit Chin Intern Med,2022,36(3):23-26.
- 43.CUI Y T,FAN Y H,DU G H,et al.Research progress on immunomodulatory effect of Chinese patent medicine containing astragalus on week health and susceptible persons[J].J Shanxi Univ Chin Med,2022,23(4):386-392.
- 44.WEN J W,FENG Y P,SHEN Z H,et al.Effect of total flavonoids of astragalus membranaceus on immune function and cytokines in rats with pneumocystis pneumonia[J].Chin J Control Endem Dis,2023,38(4):335-337.
- 45.QIAO M,GAN Y,ZHU J H,et al.Protective effect of Feikang Yiqi granule on lipopolysaccharide-induced acute lung injury in rats and immunomodulatory effect[J].Liaoning J Tradit Chin Med,2022,49(4):190-193.
- 46.GAN Y,SHI Y,QIAO M,et al.Protective effect of Feikang Yiqi granule on lipopolysaccharide-induced acute lung injury in rats and immunomodulatory effect[J].Liaoning J Tradit Chin Med,2022,24(1):22-25.
- 47.XIA H N.Study on the mechanism of Xiaochaihu decoction ininhibiting pulmonary inflammation during the recoveryperiod of COVID-19[D].Dalian:Dalian Medical University,2023.
- 48.GUO S,WU W X,XIE H,et al.Molecular mechanism of Bufei Huoxue capsule on COVID-2019 based on network pharmacology and molecular docking[J].Chin Tradit Herb Drug,2020,51(9):2307-2316.
- 49.YANG L,LI M Y,HU W Q,et al.HPLC-Q-TOF-MS/MS and network pharmacology reveal absorbed components of Bufei pills,potential in treating respiratory disorders,and mechanism in recovery stage of COVID-19[J].China J Chin Mater Med,2024,49(20):5598-5609.
- 50.LV N,YUE B S,ZHANG W H,et al.Mechanism of Xuanfei Dayu decoction in treating the recovery stage of COVID-19 based on network pharmacology and molecular docking technology[J].China Pharm,2021,24(11):2002-2011.
- 51.YIN Y Y,YUE Z D,DING Y,et al.Study on the mechanism of Buzhong Yiqi decoction on the recovery period of COVID-19 based on network pharmacology[J].J Shandong Univ Tradit Chin Med,2021,45(5):685-694.
- 52.CHEN R L,CAO F,TONG H S,et al.Effects of Shengmai injection on LPS-induced inflammatory response and vascular endothelial cell injury in septic rats[J].J Clin Emerg,2016,17(8):621-624.
- 53.TIAN Y,LI R M,REN H W,et al.Feasibility of Shengmai powder in convalescent patients with novel coronavirus pneumonia[J].Drug Eval Res,2020,43(3):378-383.
- 54.GONG P Y,XIAO G X,LI W J,et al.Analysis of the mechanisms of Guanxinning tablet for antithrombotic and microthrombotic effects caused by COVID-19 based on network pharmacology[J].Acta Pharm Sin,2024,59(9):2545-2555.
- 55.BAI Z,LI P,WEN J,et al.Inhibitory effects and mechanisms of the anti-covid-19 traditional Chinese prescription,Keguan-1,on acute lung injury[J].J Ethnopharmacol,2022,285:114838.
- 56.WANG J B,WANG Z X,JING J,et al.Exploring an integrative therapy for treating COVID-19:A randomized controlled trial[J].Chin J Integr Med,2020,26 (9):648-655.
- 57.WANG H X,LUAN Z Y,FENG J H.Role of supplementing Qi and activating blood in preventing relapse after recovery of community-acquired pneumonia with syndrome of lung deficiency and collateral stasis[J].Chin J Exp Tradit Med Form,2024,30(14):232-239.
- 58.XIONG F,GONG P,LIU Y J,et al.To analyze the feasibility of blood-activating and stasis-removing Chinese hebal drugs in the treatment of COVID-19 during convalescence[J].Res Integr Tradit Chin West Med,2020,12(4):272-275.
- 59.CHEN X X,HAN S,FAN G H,et al.Research progress of modern pharmacology of traditional Chinese medicine for promoting blood circulation and removing stasis[J].Tianjin J Tradit Chin Med,2023,40(2):250-257.
- 60.MAO M L,XIE L Y,LUO W K,et al.Research progress on pharmacological mechanisms of Danshen(Salviae Miltiorrhizae Radix et Rhizoma) and its active ingredients on cardiovascular system[J].Chin Arch Tradit Chin Med,2024,42(7):120-124.
- 61.XU W T,WANG X F.Observation on the effect of blood-activating/stasis-resolving Chinese herbal drugs in the treatment of persistent pneumonia in children[J].Guangxi J Tradit Chin Med,2017,40(5):3-5.
- 62.GUO J N,BAI X,ZHANG H X,et al.Discussion on treating pediatric pneumonia convalescence from stagnant heat based on the concept of preventing disease from exacerbating[J].China J Tradit Chin Med Pharm,2023,38(10):4742-4745.
- 63.MO M H.Compound salvia miltiorrhiza injection in the treatment of 50 children with pneumonia in the recovery period of rales[J].J Tradit Chin Med,2008,49(2):146.
- 64.LI N,SHENG K J,PENG G X,et al.Effect of Shenfu injection assisted with antibiotics on the subsided time of clinical symptoms,endothelial cell damage factor and pulmonary function in elderly patients with severe pneumonia[J].Practical Geriatrics,2019,33(8):764-767.
- 65.ROMERO-DUARTE Á,RIVERA-IZQUIERDO M,GUERRERO-FERNÁNDEZ DE ALBA I,et al.Sequelae,persistent symptomatology and outcomes after COVID-19 hospitalization:The ANCOHVID multicentre 6-month follow-up study[J].BMC Med,2021,19(1):129.
- 66.TIAN Y,ZHANG S,ZHENG W K,et al.Qingjin Yiqi granule in the treatment of low fever in convalescence of COVID-19(Omicron):A case report[J].Tianjin J Tradit Chin Med,2022,39(6):692-696.
- 67.JIANG N,WANG K,LI X D,et al.Study on the distribution and evolution of traditional Chinese medicine syndromes in patients infected with the SARS-CoV-2 Omicron variant after nucleic acid turned negative[J].Tianjin J Tradit Chin Med,2023,40(2):140-145.
- 68.WANG Q L,SUN L F,ZHAO M F,et al.Application of TCM comprehensive rehabilitation system in the treatment of new coronavirus pneumonia in convalescence[J].J Sichuan Tradit Chin Med,2023,41(6):110- 114.
- 69.DU B Y,GAO J,LIU C Y,et al.Observation of the curative effect of Yupingfeng granule and Spleen Aminopeptide in the children with pneumonia and syndrome of lung-spleen deficiency in recovery stage[J].Mod J Integr Tradit Chin West Med,2017,26(35):3883-3885,3963.
- 70.LI L,GOU C Y,LI X M,et al.Effects of Chinese medicine on symptoms,syndrome evolution,and lung inflammation absorption in COVID-19 convalescent patients during 84-day follow-up after hospital discharge:A prospective cohort and nested case-control study[J].Chin J Integr Med,2021,27(4):245-251.
- 71.CHEN Y,LIU C,WANG T,et al.Efficacy and safety of Bufei Huoxue capsules in the management of convalescent patients with COVID-19 infection:A multicentre,double-blind,and randomised controlled trial[J].J Ethnopharmacol,2022,284:114830.
- 72.LI W K,YANG J,CHEN R Y,et al.Clinical efficacy study of Bufei Huoxue capsules in treatment of SARS-CoV-2 infection recovery phase with qi deficiency and blood stasis syndrome[J].Chin Tradit Herb Drug,2024,55(3):872-881.
- 73.LIU X R,PAN Y,ZHANG J Y,et al.Clinical study on the treatment of children pneumonia convalescent period with Yiqi Jianpi Huoxue method[J].Clin J Tradit Chin Med,2014,26(12):1243-1244.
- 74.TIAN X R,LI X Z,ZHU J,et al.Effect of Tongfu Yiqi Huoxue decoction combined with alveolar lavage in the treatment of pneumonia sepsis and its influence on T lymphocyte subsets and mitochondrial damage index[J].Hainan Med J,2024,35(1):29-34.


