References
- 1.BROWN L C,BOBO W V,GALL C A,et al.Pharmacomicrobiomics of antidepressants in depression:A systematic review[J].J Pers Med,2023,13(7):1086.
- 2.LI X M,GE T H,DONG Q,et al.Social participation,psychological resilience and depression among widowed older adults in China[J].BMC Geriatr,2023,23(1):454.
- 3.CHEN P,BAI W,LI X H,et al.Research on major depression in China:A perspective from bibliometric analysis[J].J Affect Disord,2022,315(10):174-181.
- 4.Report on the Nutrition and Chronic Disease Status of Chinese Residents(2020)[J].Acta Nutr Sin,2020,42(6):521.
- 5.KVERNO K S,MANGANO E.Treatment-resistant depression:Approaches to treatment[J].J Psychosoc Nurs Ment Health Serv,2021,59(9):7-11.
- 6.ZHANG N J,MA B X,SHEN H X,et al.Analysis on the current situation of clinical trial registration of traditional Chinese medicine in treating depression[J].World Chin Med,2024,19(6):864-870.
- 7.ZHANG Y W,CHENG Y C.Challenge and prospect of traditional Chinese medicine min depression treatment[J].Front Neurosci,2019,13(5):190.
- 8.WANG Y Y,LI M L,LIANG Y,et al.Chinese herbal medicine for the treatment of depression:Applications,efficacies and mechanisms[J].Curr Pharm Des,2018,23(34):5180-5190.
- 9.WANG J Y,GAO Z,GAO L,et al.Research progress and predictive analysis of quality markers of classical prescription Chaihu Jia Longgu Muli decoction[J].Chin Arch Tradit Chin Med,2023,41(4):29-36.
- 10.JIANG N,ZHANG Y W,YAO C H,et al.Overview of animal behavioral tests of depression[J].Acta Lab Anim Sci Sin,2021,29(6):830-838.
- 11.PICARD K,BISHT K,POGGINI S,et al.Microglial-glucocorticoid receptor depletion alters the response of hippocampal microglia and neurons in a chronic unpredictable mild stress paradigm in female mice[J].Brain Behav Immun,2021,97:423-439.
- 12.WILLNER P,TOWELL A,SAMPSON D,et al.Reduction of sucrose preference by chronic unpredictable mild stress,and its restoration by a tricyclic antidepressant[J].Psychopharmacology (Berl),1987,93(3):358-364.
- 13.ZHANG W,SHI H L,WU X J,et al.Research progress of mechanism of blood-brain barrier abnormality induced by neurodegenerative diseases and the effect of traditional Chinese medicine on blood-brain barrier abnormity[J].Anhui Med Pharm J,2016,20(9):1621-1625.
- 14.XU J M,CHEN W L,LIU S G,et al.Research progress of flavonoid Chinese herbal extract monomers in multiple sclerosis[J].Adv Clin Med,2022,12(6):5713-5719.
- 15.TARTT A N,MARIANI M B,HEN R N,et al.Dysregulation of adult hippocampal neuroplasticity in major depression:Pathogenesis and therapeutic implications[J].Mol Psychiatry,2022,27(6):2689-2699.
- 16.RODDY D W,FARRELL C,DOOLIN K,et al.The hippocampus in depression:More than the sum of its parts? Advanced hippocampal substructure segmentation in depression[J].Biol Psychiatry,2019,85(6):487-497.
- 17.BROSCH K,STEIN F,SCHMITT S,et al.Reduced hippocampal gray matter volume is a common feature of patients with major depression,bipolar disorder,and schizophrenia spectrum disorders[J].Mol Psychiatry,2022,27(10):4234-4243.
- 18.HILL A S,SAHAY A,HEN R.Increasing adult hippocampal neurogenesis is sufficient to reduce anxiety and depression-like behaviors[J].Neuropsychopharmacology,2015,40(10):2368-2378.
- 19.VAN TOL M J,VAN DER WEE N J A,VAN DEN HEUVEL O A,et al.Regional brain volume in depression and anxiety disorders[J].Arch Gen Psychiatry,2010,67(10):1002-1011.
- 20.MCEWEN B S,EILAND L,HUNTER R G,et al.Stress and anxiety:Structural plasticity and epigenetic regulation as a consequence of stress[J].Neuropharmacology,2012,62(1):3-12.
- 21.PRICE R B,DUMAN R.Neuroplasticity in cognitive and psychological mechanisms of depression:An integrative model[J].Mol Psychiatry,2020,25(3):530-543.
- 22.JIANG N,WANG H X,LV J W,et al.Dammarane sapogenins attenuates stress-induced anxiety-like behaviors by upregulating ERK/CREB/BDNF pathways[J].Phytother Res,2020,34(10):2721-2729.
- 23.YAO W,CAO Q Q,LUO S L,et al.Microglial ERK-NRBP1-CREB-BDNF signaling in sustained antidepressant actions of (R)-ketamine[J].Mol Psychiatry,2022,27(3):1618-1629.
- 24.ALBERT-GASCÓ H,ROS-BERNAL F,CASTILLO-GÓMEZ E,et al.MAP/ERK signaling in developing cognitive and emotional function and its effect on pathological and neurodegenerative processes[J].Int J Mol Sci,2020,doi:.
- 25.ZHANG N,ZHANG L,FENG L Y,et al.Cananga odorata essential oil reverses the anxiety induced by 1-(3-chlorophenyl) piperazine through regulating the MAPK pathway and serotonin system in mice[J].J Ethnopharmacol,2018,219:23-30.
- 26.MICHALAK A,WNOROWSKI A,BERARDINELLI A,et al.Diazepam and SL-327 synergistically attenuate anxiety-like behaviours in mice-Possible hippocampal MAPKs specificity[J].Neuropharmacology,2020,180:108302.
- 27.MAO L M,WANG J Q.Synaptically localized mitogen-activated protein kinases:Local substrates and regulation[J].Mol Neurobiol,2016,53(9):6309-6315.
- 28.MORÈ L,PRIVITERA L,PERRETT P,et al.CREB serine 133 is necessary for spatial cognitive flexibility and long-term potentiation[J].Neuropharmacology,2022,219:109237.
- 29.GUO C,LIU Y,FANG M S,et al.ω-3PUFAs improve cognitive impairments through Ser133 phosphorylation of CREB upregulating BDNF/TrkB signal in schizophrenia[J].Neurotherapeutics,2020,17(3):1271-1286.
- 30.LUO Z H,PANG S,ZHANG L F.Advances of CREB in the regulation of memory through synaptic plasticity and its relationship with Alzheimer's disease[J].Chin J Comp Med,2023,33(11):104-109.
- 31.ZHANG Y J,ZHANG W,XU M S,et al.A probe into electric needling to regulatory mechanism expressed by BDNF in the hippocampi in PSD rats based on BDNF/ERK/CREB signal transduction pathway[J].Jiangsu J Tradit Chin Med,2020,52(3):81-85.
- 32.YAO B H,LIU H J,ZHANG X,et al.Study on neuroprotective effect of NBP on BDNF/ERK1/2-CREB pathway in rats with chronic alcoholism[J].Jilin Med J,2022,43(5):1168-1171.
- 33.YANG W F,WANG Q,YANG Z C,et al.Advances in the mechanisms of inflammation-driven pathogenesis and progression of depression[J].Acad J Jiangsu Univ:Med Ed,2023,33(5):449-454,460.
- 34.LEI H W,ZHANG F,ZHOU C E,et al.Effects of ethyl acetate extract of Taxus Chinensis Fruit on phenotype and inflammatory cytokines in rats with depression[J]. World Chin Med,2024,19(8):1074-1077,1084.
- 35.LANA D,IOVINO L,NOSI D,et al.The neuron-astrocyte-microglia triad involvement in neuroinflammaging mechanisms in the CA3 hippocampus of memory-impaired aged rats[J].Exp Gerontol,2016,83:71-88.
- 36.NAGAYACH A,PATRO N,PATRO I.Astrocytic and microglial response in experimentally induced diabetic rat brain[J].Metab Brain Dis,2014,29(3):747-761.
- 37.LI M Z,OUYANG J Y,YANG L,et al.Effect of total steroid saponin of Trillium tschonoskii Maxim on astrocyte GFAP,Cx43 and Wnt3a/Dvl3 signaling pathway in rats with cerebral ischemia[J].Chin J Inf Tradit Chin Med,2022,29(5):75-80.


