ObjectiveTo observe the clinical efficacy and safety of Yanling Yishou Formula combined with aerobic exercise in the intervention of heart and spleen deficiency syndrome in middle-aged white-collar workers with "stress-induced aging".MethodsA non-randomized controlled trial was conducted to include 156 patients with heart and spleen deficiency syndrome in middle-aged white-collar workers with "stress-induced aging"：and were divided into treatment group and control group according to whether or not to take Yanling Yishou Formula，78 cases in each group. The treatment group was treated with Yanling Yishou Formula combined with aerobic exercise，and the control group was treated withaerobic exercise. Yanling Yishou Formula is derived from Qinggong Medical Cases：Suan-zao-ren 10g，Dang-shen 10g，Huang-qi 10g，Bai-shao 10g，Dang-gui 10g，Sheng-di-huang 10g，Bai-zu 10g，Fu-ling 10g，Gan-cao 10g，decocted in water，taken 2 hours after breakfast and dinner respectively. Aerobic exercise is based on the 2017 American College of Sports Medicine guidelines. Aerobic exercise are divided into three phases，warm-up phase（5 mins），aerobic running phase（increased by one or two minutes up to a maximum of 20 minutes），relaxation phase（10 mins）. The course of treatment in both groups maintenanced for 28 days. Participants were followed-up for 35 days. Outcomes included Checklist Individual Strength（CIS），Sleep Quality（sleep time and sleep period），TCM Symptom Score，Short form 36 questionnaire physical function（SF-36 PF），Hospital Anxiety and Depression Scale（HADS），Pain Visual Analogue Score（Pain VAS）.ResultsCompared with the group before treatment，participants in the treatment group reported higher decrease in CIS，TCM Symptom Score，and a better improvement in sleep quality.Compared with before treatment，the observation group showed a greater decrease in CIS and better improvement in sleep quality （P<0.05，P<0.01）； There was no statistically significant improvement in CIS and sleep in the control group； After treatment，compared with the control group，the observation group reported a greater decrease in CIS and better improvement in sleep quality （P<0.05，P<0.01）.In terms of traditional Chinese medicine syndrome scores，compared with before treatment，the observation group showed significant improvements in fatigue，easy awakening，frequent dreaming，poor diet，palpitations，and loose stools （P<0.05，P<0.01），while the control group showed no statistically significant improvement in poor diet，palpitations，and loose stools； Compared with the control group after treatment，the observation group showed better improvement in fatigue，easy awakening，frequent dreaming，and palpitations （P<0.05，P<0.01）.. However，there was no statistically significant difference in SF-36 PF，HADS，and pain VAS between the two groups before and after treatments.ConclusionYanling Yishou Formula combined with aerobic exercise can alleviate fatigue symptoms in middle-aged white-collar workers，improve sleep quality，and enhance patients' quality of life.

Stress-induced Aging;Deficiency of the heart and spleen pattern;Middle aged white-collar worker;Yanling Yishou Formula;Aerobic exercise