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Progrès dans la recherche sur la décoction de Chaihu Guizhi Ganjiang et ses composants actifs pour le traitement de la dyspepsie liée à la cholécystite chronique

  • role： First author第一作者
  • Affiliation：

    School of Clinical Chinese Medicine，Gansu University of Chinese Medicine， Lanzhou 730030，China

  • Email：194691377@qq.com
  • Introduction：杨文文，硕士，住院医师，从事消化系统疾病的中医药防治研究，E-mail：194691377@qq.com
YANG Wenwen1,  
  • role： Corresponding author通信作者
  • Affiliation：

    Diagnosis and Treatment Center of Spleen and Stomach Diseases，Gansu Provincial Hospital of Traditional Chinese Medicine，Lanzhou 730050，China

  • Email：luyubei0618@126.com
  • Introduction：卢雨蓓，硕士，主任医师，从事消化系统疾病的中医药防治研究，E-mail：luyubei0618@126.com； *
LU Yubei2*,  
  • Affiliation：

    School of Clinical Chinese Medicine，Gansu University of Chinese Medicine， Lanzhou 730030，China

CHEN Lin1,  
  • role： Corresponding author通信作者
  • Affiliation：

    Affiliated Hospital of Gansu University of Chinese Medicine，Lanzhou 730030，China

  • Email：17181871@qq.com
  • Introduction：张晶，硕士，副教授，副主任医师，从事消化系统疾病的中医药防治研究，E-mail：17181871@qq.com
ZHANG Jing3*,  
  • Affiliation：

    School of Clinical Chinese Medicine，Gansu University of Chinese Medicine， Lanzhou 730030，China

GAO Ying1,  
  • Affiliation：

    School of Clinical Chinese Medicine，Gansu University of Chinese Medicine， Lanzhou 730030，China

ZHANG Yajuan1,  
  • Affiliation：

    School of Clinical Chinese Medicine，Gansu University of Chinese Medicine， Lanzhou 730030，China

LI Xiaoyan1,  
  • Affiliation：

    School of Clinical Chinese Medicine，Gansu University of Chinese Medicine， Lanzhou 730030，China

YANG Jianfei1,  
  • Affiliation：

    School of Clinical Chinese Medicine，Gansu University of Chinese Medicine， Lanzhou 730030，China

SHI Xiaoli1,  
  • Affiliation：

    School of Clinical Chinese Medicine，Gansu University of Chinese Medicine， Lanzhou 730030，China

LIN Huanhuan1

résumé

La décoction de Chaihu Guizhi Ganjiang est mentionnée pour la première fois dans le "Shanghan Lun". La prescription est composée de sept ingrédients : Chaihu, Huangqin, Guizhi, Ganjiang, Racine de Gualou, Ostre, et Gancao. Elle a pour effet de disperser le Shaoyang, de réchauffer la rate et de stimuler la production de fluides. Cliniquement, elle est souvent utilisée pour traiter la cholécystite chronique (CC), le syndrome du côlon irritable, la stéatose hépatique non alcoolique, et diverses maladies gastro-intestinales. La dyspepsie liée à la CC est un ensemble de symptômes cliniques causés par la CC, incluant douleurs abdominales, perte d'appétit, satiété postprandiale, aversion aux aliments gras, selles molles, goût amer en bouche, etc., classée comme une forme de dyspepsie d'origine biliaire (BD). La médecine moderne utilise principalement des traitements médicaux internes et chirurgicaux. Le traitement interne vise principalement à soulager l'inflammation, favoriser l'expulsion des calculs biliaires, réduire les spasmes et la douleur, et à améliorer la digestion des symptômes de la dyspepsie. Les effets à court terme sont acceptables, mais il existe des problèmes tels que l'action limitée, un taux élevé de récidive et une faible dépendance. La chirurgie peut guérir la cholécystite, mais augmente le risque d'événements indésirables tels que douleurs abdominales, diarrhée et dyspepsie. Des preuves cliniques modernes montrent que la décoction de Chaihu Guizhi Ganjiang améliore significativement les douleurs abdominales et la dyspepsie chez les patients atteints de CC. Les recherches pharmacologiques ont identifié des composants majeurs tels que les saponines de Chaihu, la baicaline, la cinnamaldéhyde, le gingérol, le shogaol, les polysaccharides de Radix Trichosanthis, les polysaccharides d'huîtres, et les flavonoïdes totaux de Gancao. Ils peuvent améliorer les symptômes de la dyspepsie liée à la CC via plusieurs mécanismes : inhibition de l'inflammation, amélioration de la contraction de la vésicule biliaire et de la motilité gastro-intestinale, régulation de l'axe acides biliaires - microbiote intestinal, régulation des lipides sanguins, régulation de l'axe cerveau-intestin. Cet article passe en revue les recherches antérieures sur la décoction de Chaihu Guizhi Ganjiang et les principaux composants actifs dans le traitement de la dyspepsie associée à la cholécystite chronique, discute des lacunes actuelles et propose des stratégies d'amélioration, afin de fournir une référence pour des recherches futures.

mots-clés

Décoction de Chaihu Guizhi Ganjiang;Composants actifs;Cholécystite chronique;Dyspepsie;Revue

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