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漢方薬による小胞体ストレス調節を介した潰瘍性大腸炎治療の研究進展

  • role： First author第一作者
  • Affiliation：

    Hubei University of Chinese Medicine，Wuhan 430065，China

  • Email：yankeqiu1996@163.com
  • Introduction：颜克秋，在读博士，从事中医药防治肛肠疾病的研究，E-mail：yankeqiu1996@163.com
YAN Keqiu1,  
  • Affiliation：

    Hubei Provincial Hospital of Traditional Chinese Medicine，Wuhan 430061，China

    Affiliated Hospital of Hubei University of Chinese Medicine，Wuhan 430061，China

    Hubei Provincial Institute of Traditional Chinese Medicine，Wuhan 430061，China

ZHANG Xiaoyu234,  
  • Affiliation：

    Hubei Provincial Hospital of Traditional Chinese Medicine，Wuhan 430061，China

    Affiliated Hospital of Hubei University of Chinese Medicine，Wuhan 430061，China

    Hubei Provincial Institute of Traditional Chinese Medicine，Wuhan 430061，China

SUN Guangjun234,  
  • role： Corresponding author通信作者
  • Affiliation：

    Hubei University of Chinese Medicine，Wuhan 430065，China

    Hubei Provincial Hospital of Traditional Chinese Medicine，Wuhan 430061，China

    Affiliated Hospital of Hubei University of Chinese Medicine，Wuhan 430061，China

    Hubei Provincial Institute of Traditional Chinese Medicine，Wuhan 430061，China

  • Email：hb20190101@126.com
  • Introduction：林爱珍，博士，主任医师，从事中医药防治肛肠疾病的研究，E-mail：hb20190101@126.com
LIN Aizhen1234*

サマリー

潰瘍性大腸炎（UC）は慢性かつ再発性の炎症性腸疾患であり、主に直腸および結腸の粘膜層に影響を及ぼします。発症メカニズムは複雑であり、現時点で完全には解明されていません。小胞体ストレス（ERS）は細胞が外部からのストレスに応答し、恒常性を維持する上で重要な役割を果たしており、その異常な活性化は様々な炎症性疾患の発症と密接に関連しており、特にUCの病理進行において重要な役割を担っています。ERSは未折りたたみタンパク質応答（UPR）を活性化することで細胞の恒常性を維持しますが、ストレスが持続または過剰になるとUPRがストレスを緩和できず、腸上皮細胞の死を引き起こし、UCの病理進行を悪化させます。ERSの調節はUCの予防および治療の重要なターゲットであり、現在の研究のホットスポットでもあります。漢方薬は多標的・多経路作用を通じてERSの調節に顕著な効果を示し、独自の治療的優位性を持っています。近年の研究により、漢方薬はERSを軽減し、アポトーシスを抑制し、オートファジーを調節し、炎症反応を緩和し、腸のバリア機能を維持することでUCの予防および治療に寄与することが確認されています。本稿では、ERSとUCの関係およびERS調節による漢方薬のUC治療介入について総説し、UC治療に新たな視点と方法を提供することを目的としています。

キーワード

漢方薬;潰瘍性大腸炎;小胞体ストレス;アポトーシス;オートファジー

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