AMPK/mTORシグナル経路に基づく中薬単体の抗肝癌研究進展

  • role: First author第一作者
  • Affiliation:

    Henan University of Chinese Medicine, Zhengzhou 450053,China

  • Email:2528856234@qq.com
  • Introduction:胡洋,在读硕士,住院医师,从事消化系统疾病的中西医结合防治及内镜下诊疗研究,E-mail:2528856234@qq.com
HU Yang1,  
  • role: Corresponding author通信作者
  • Affiliation:

    Second Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou 450002,China

  • Email:18568228052@163.com
  • Introduction:胡素芹,博士,主治医师,从事消化系统疾病的中西医结合防治及内镜下诊疗研究,E-mail:18568228052@163.com
HU Suqin2*,  
  • Affiliation:

    Henan University of Chinese Medicine, Zhengzhou 450053,China

ZENG Shuo1,  
  • Affiliation:

    Second Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou 450002,China

LUO Lei2,  
  • Affiliation:

    Second Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou 450002,China

LI Mingyan2,  
  • role: Corresponding author通信作者
  • Affiliation:

    Second Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou 450002,China

  • Email:ZhangQS0725@163.com
  • Introduction:张勤生,博士,主任医师,从事消化系统疾病的中西医结合防治及内镜下诊疗研究,E-mail:ZhangQS0725@163.com; *
ZHANG Qinsheng2*

サマリー

肝癌は世界的に発病率および死亡率が高い悪性腫瘍であり、我が国においても発病および死亡数は年々増加傾向にあります。現在、西洋医学による肝癌の臨床介入は、腫瘍増殖の抑制、患者症状の緩和、病状悪化の遅延に一定の成果を上げていますが、顕著な副作用、進行する薬剤耐性、患者の生存率向上の限界など問題点も無視できません。したがって、より効率的かつ安全な治療法の探索が腫瘍医学分野における喫緊の課題となっています。アデノシン一リン酸活性化プロテインキナーゼ(AMPK)および哺乳類ラパマイシン標的タンパク質(mTOR)シグナル経路は、肝癌細胞の増殖、分化、アポトーシスおよびオートファジーなどの生理過程において中心的な調節機能を果たし、肝癌治療の重要な分子標的と考えられています。中医学は、多経路・多機序の相乗的抗肝癌特性を活かし、現在の肝癌の総合的治療体系において重要な要素となっており、明確な化学構造と解明可能な薬効機序を兼ね備えた中薬単体は、現代の抗肝癌薬開発における重要な突破口となっています。研究により、フラボノイド類、アルカロイド類、多酚類、サポニン類、テルペノイド類、キノン類など多種の中薬単体が、AMPK/mTORシグナル経路およびその上下流タンパク質発現を調節し、肝癌細胞のオートファジーとアポトーシスを誘導し、有酸素的解糖を抑制し、肝癌耐性を逆転させ、フェロプトーシスを促進し、上皮間葉転換を阻害し、血管新生を抑制することで、肝癌細胞の増殖と拡散を効果的に抑制することが示されています。これに基づき、本稿は近年の中薬単体の抗肝癌研究を体系的に整理し、AMPK/mTORシグナル経路の調節を通じた抗肝癌メカニズムを深く解析し、新たな抗肝癌薬開発の方向性と参考を提供します。

キーワード

アデノシン一リン酸活性化プロテインキナーゼ(AMPK);哺乳類ラパマイシン標的タンパク質(mTOR);中薬単体;肝癌;研究進展

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