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異なる調理技法に基づく炒め共通規則と特性の違いの探索

  • role： First author第一作者
  • Affiliation：

    School of Pharmacy，Jiangxi University of Chinese Medicine，Nanchang 330004，China

    Jingning She Medicine Research Institute，Lishui 323500，China

  • Email：507598522@qq.com
  • Introduction：刘洪，硕士，从事中药炮制机制及其药效研究，E-mail：507598522@qq.com
LIU Hong12,  
  • role： Corresponding author通信作者
  • Affiliation：

    School of Pharmacy，Jiangxi University of Chinese Medicine，Nanchang 330004，China

  • Email：ly1638163@163.com
  • Introduction：钟凌云，教授，从事中药炮制学研究，E-mail：ly1638163@163.com
ZHONG Lingyun1*,  
  • Affiliation：

    School of Pharmacy，Jiangxi University of Chinese Medicine，Nanchang 330004，China

DENG Yanwen1,  
  • Affiliation：

    School of Pharmacy，Jiangxi University of Chinese Medicine，Nanchang 330004，China

LU Xingmei1,  
  • Affiliation：

    School of Pharmacy，Jiangxi University of Chinese Medicine，Nanchang 330004，China

WANG Shuo1

サマリー

漢方薬の調理法は、製剤の中核技術として、火加減の勾配と補助材料との協力により、薬物の物質効果を調節する。この論文は、異なる炒め加温度（炒め黄、炒め焦げ、炒め炭）および補助材料タイプ（米、麦ふすま、土などの固体補助材料；酒、酢、蜂蜜などの液体補助材料）が漢方薬の理化学的性質、薬効および毒性に与える影響規則を体系的に解析し、その共通規則と特性の違いをまとめた。異なる炒め加工工程の三次元調節共通操作-五次元調節特性メカニズムを明らかにし、三次元調節共通メカニズムは、①熱作用が薬材の固有のバリアを壊し、成分の溶出度を向上させる；②薬材にメイラード反応、炭化反応を促進し、成分の変容を促進する; ③補助材料の触媒作用、調和作用を結合し、薬効物質の方向性の濃縮と毒性成分の精密な制御を実現する。五次元調節特性は、①「炒め黄が脾を丈夫にし、炒め焦が胃を活性化させ、炒め炭が出血を止める」薬効の傾斜規則を示す；②液体補助材料は、極性の差異と自らの特性により、「酒製は目上を向上、ショウガ製は温散、塩製は腎に入り、酢製は肝に帰り、蜜製は甘緩」の方向性強化メカニズムを形成する；③固体補助材料は、多孔構造と界面特性により、「米製は下痢を停止し、麦ふすまは胃を丈夫にし、土製は胃中を暖め、蛤粉/滑石粉/砂製は質感を最適化する」共同薬効を付与する; ④熱作用により分解/酸化/重合などの反応を誘導し、物質の基礎を再構築し、薬効を方向性改善する; ⑤成分の濃縮とその前附け作用を経絡し、薬効の目標分布を調整し、薬剤経絡を変える。このシステムは、熱作用、補助材料の協力、物化学的再構築を駆動力とし、火加減、溶媒、界面、成分、分布の五次元調節を融合し、伝統的な漢方薬の「薬性-物質-製法」の内在的な規則を体系的に解説し、漢方薬の規格化と漢方薬の効果を向上させるための理論的根拠と実践指導を提供する。

キーワード

漢方薬の製剤；炒め加温度；固体補助材料；液体補助材料；共通規則；特性の違い；薬性薬効

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