이전|다음

폐경 전후기 우울증 동물 모델 구축 및 중약 작용 기전 연구 진전

  • role： First author第一作者
  • Affiliation：

    Shaanxi University of Chinese Medicine， Xianyang 712046，China

  • Email：chita15181377283@163.com
  • Introduction：李晓婷，在读硕士，从事食疗营养、治未病在慢病防治中的理论及应用研究，E-mail：chita15181377283@163.com
LI Xiaoting1,  
  • Affiliation：

    Shaanxi University of Chinese Medicine， Xianyang 712046，China

XU Shouzhu1,  
  • Affiliation：

    Shaanxi University of Chinese Medicine， Xianyang 712046，China

KE Jun1,  
  • Affiliation：

    Shaanxi University of Chinese Medicine， Xianyang 712046，China

ZHANG Zhan1,  
  • role： Corresponding author通信作者
  • Affiliation：

    Shaanxi University of Chinese Medicine， Xianyang 712046，China

    The Second Affiliated Hospital of Shaanxi University of Chinese Medicine， Xianyang 710003，China

  • Email：344016745@qq.com
  • Introduction：辛宝，硕士生导师，教授，从事食疗营养、治未病在慢病防治中的理论及应用研究，E-mail：344016745@qq.com
XIN Bao12*

추상적인

폐경 전후기 우울증(PMD)은 여성의 성숙기에서 노년기로 이행하는 단계에서 발생하는 정서 장애성 질환으로, 불면증, 인지 기능 저하 등 다양한 합병증을 유발할 수 있다. PMD의 원인은 복잡하며, 여러 가설이 제기되었지만 현재까지 PMD의 발병 기전을 완전히 설명할 수 있는 통일된 이론은 없다. 기전 연구는 동물 실험 없이는 불가능하며, 신뢰할 수 있는 동물 모델 구축은 연구에 매우 중요하다. 적절한 동물 모델은 인간의 병태생리 상태를 더 잘 모사할 수 있으며, 약물 및 중재 방법의 효과와 안전성을 빠르게 평가하고, 질병의 본질을 파악하며 내재된 연관성을 발견하여 보다 진보된 중재 전략을 탐색하는 데 도움이 된다. 그러나 현재까지 모델 구축 관련 문헌의 정리와 요약이 부족한 상태이다. 또한 중의학은 ‘변증론치’와 ‘전체론’ 치료 철학을 기반으로 PMD 치료에 효과적이며, 최근 그 치료 기전에 대한 연구가 증가하고 있다. 따라서 PMD 동물 모델 구축 방법과 중약 기전에 대한 명확한 이해를 위해 본 논문은 PMD 동물 모델과 중약 치료 기전에 관한 한중 문헌을 검색하여 단일 인자 및 다인자 PMD 모델 구축 방법을 요약 분석하였으며, 각 모델링 방법의 장단점을 설명하였다. 동시에 중약 개입 PMD 기초연구의 중의약 작용 기전을 심층 분석하여, 중약 복방 치료 기전이 주로 시상하부-뇌하수체-부신(HPA) 축, 시상하부-뇌하수체-난소(HPO) 축, 장-뇌 축, 세포 신호 전달 경로, 신경 회로, 호르몬 및 신경전달물질 수준 등을 조절함으로써 작용함을 발견하였다. 향후 이 분야 연구에 참고가 되기를 기대한다. 요약하면, 본 논문은 PMD 동물 모델 구축 방법과 중약 작용 기전 연구 진전을 정리하여 중의학이 PMD에 미치는 기전 연구에 새로운 아이디어를 제공하는 것을 목적으로 한다.

키워드

폐경 전후기 우울증;동물 모델;평가 방법;중의학 기전

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