이전|다음

PI3K/Akt 신호 경로 기반 한약의 식도암 치료 연구 진전

  • role： First author第一作者
  • Affiliation：

    The First Affiliated Hospital of Henan University of Chinese Medicine，Zhengzhou 450000，China

    The First Clinical Medical School of Henan University of Chinese Medicine，Zhengzhou 450046，China

  • Email：507389736@qq.com
  • Introduction：郭伟，在读硕士，从事中西医结合防治恶性肿瘤疾病研究，E-mail：507389736@qq.com
GUO Wei12,  
  • Affiliation：

    The First Affiliated Hospital of Henan University of Chinese Medicine，Zhengzhou 450000，China

    The First Clinical Medical School of Henan University of Chinese Medicine，Zhengzhou 450046，China

PENG Chen12,  
  • Affiliation：

    The First Affiliated Hospital of Henan University of Chinese Medicine，Zhengzhou 450000，China

    The First Clinical Medical School of Henan University of Chinese Medicine，Zhengzhou 450046，China

WANG Yikun12,  
  • Affiliation：

    The First Affiliated Hospital of Henan University of Chinese Medicine，Zhengzhou 450000，China

    The First Clinical Medical School of Henan University of Chinese Medicine，Zhengzhou 450046，China

YU Zixuan12,  
  • Affiliation：

    The First Affiliated Hospital of Henan University of Chinese Medicine，Zhengzhou 450000，China

    The First Clinical Medical School of Henan University of Chinese Medicine，Zhengzhou 450046，China

LIU Jintao12,  
  • Affiliation：

    The First Affiliated Hospital of Henan University of Chinese Medicine，Zhengzhou 450000，China

    The First Clinical Medical School of Henan University of Chinese Medicine，Zhengzhou 450046，China

DING Jing12,  
  • Affiliation：

    The First Affiliated Hospital of Henan University of Chinese Medicine，Zhengzhou 450000，China

    The First Clinical Medical School of Henan University of Chinese Medicine，Zhengzhou 450046，China

LI Yijing12,  
  • role： Corresponding author通信作者
  • Affiliation：

    The First Affiliated Hospital of Henan University of Chinese Medicine，Zhengzhou 450000，China

  • Email：447334004@qq.com
  • Introduction：孙宏新，博士，主任医师，从事中西医结合防治恶性肿瘤疾病研究，E-mail：447334004@qq.com
SUN Hongxin1*

추상적인

식도암(EC)은 우리나라에서 발병률이 높은 악성 종양 중 하나이며, 인산지질 3-키나제(PI3K)/단백질 키나제 B(Akt) 신호 경로는 발암의 주요 경로 중 하나로서 EC 세포 주기 진행, 증식, 이동 및 침습을 촉진하고 EC 세포의 방사선 및 화학요법 내성을 유도하며 세포자멸사와 자가포식을 억제한다. 한약은 다중 표적과 다중 성분의 장점을 통해 PI3K/Akt 신호 경로를 표적으로 하여 EC를 치료할 수 있다. 본 논문은 EC에서 PI3K/Akt 신호 경로의 분자 기전과 역할을 예비적으로 탐구하고, 최근 5년간 중약이 PI3K/Akt 신호 경로를 개입하여 EC를 치료하는 구체적인 표적과 효능을 상세히 설명하였다. EC에서 PI3K/Akt 신호 경로를 억제하는 중약에는 천연빙편, 포자막 제거 영지 포자 가루, 남사등 추출물, 민들레 뿌리 추출물, 야담자유유 유화제가 포함된 단미 중약 및 중약 추출물이 있으며, 활성 성분으로는 플라보노이드, 테르펜, 사포닌, 페놀, 다당류, 알칼로이드 및 기타 화합물이 있다. 중약 복방에는 기격산, 호칠산, 선복대칠탕, 통유탕 및 그 분해방, 육군자탕, 셀레늄 인삼방, 그리고 복합 쑤진 주사액과 강애 주사액 등 중약 복방 추출 중성약 주사액이 있다. 본 논문은 PI3K/Akt 신호 경로를 기반으로 EC에서의 역할 기전 및 중약 개입 역할을 정리하여 EC 신약 연구 및 임상 적용에 참고 자료를 제공하고자 한다.

키워드

인산지질 3-키나제(PI3K)/단백질 키나제 B(Akt);식도암;한약;연구 진전

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