이전|다음

PI3K/Akt 신호 경로 기반 한의학의 근감소증 치료 연구 진전

  • role： First author第一作者
  • Affiliation：

    The First Affiliated Hospital of Henan University of Chinese Medicine，Zhengzhou 450000，China

  • Email：cy15937179269@163.com
  • Introduction：陈言，在读博士，从事常见功能障碍中医康复的临床与基础研究，E-mail：cy15937179269@163.com
CHEN Yan1,  
  • Affiliation：

    The First Affiliated Hospital of Henan University of Chinese Medicine，Zhengzhou 450000，China

DAI Ting1,  
  • Affiliation：

    Heilongjiang University of Chinese Medicine，Harbin 150040，China

GUO Changsheng2,  
  • role： Corresponding author通信作者
  • Affiliation：

    The First Affiliated Hospital of Henan University of Chinese Medicine，Zhengzhou 450000，China

  • Email：13607649136@163.com
  • Introduction：冯志海，教授，主任中医师，硕士生导师，从事中医药防治内分泌疾病的研究，E-mail：13607649136@163.com
FENG Zhihai1*

추상적인

근감소증은 골격근의 전신성 질환으로 근육량, 힘 및 기능이 점진적으로 감소하는 질환이며, 발생과 진행은 다양한 요인과 여러 신호 경로와 관련이 있다. 이 중 인지질 삼인산(PI3K)/단백질 키나제 B (Akt) 신호 경로는 세포 성장, 생존 및 대사를 조절하는 주요 경로로서 근감소증의 형성과 발전에 중요한 역할을 한다. 이 경로의 이상 활성화 또는 비활성화는 근육 단백질 대사의 불균형을 초래하여 근육 위축 및 감소를 유발할 수 있다. 현대 의학은 근감소증 치료에 대해 아직 탐색 단계에 있으며, 한의학은 다경로, 다표적 특성으로 근감소증 예방 및 치료에 점차 두드러진 장점을 보여주고 있다. 최근 다양한 한약 단일체, 추출물 및 복방이 근단백 합성 촉진, 근단백 분해 감소, 세포자멸사 및 염증 반응 억제, 미토콘드리아 기능 개선 등의 기전을 통해 근감소증을 효과적으로 예방 및 치료하는 것으로 확인되었다. 본 논문은 PI3K/Akt 경로를 기반으로 한의학이 근감소증 개선에 미치는 영향을 종합적으로 검토하고 구체적인 작용 기전을 탐구하여 한의학의 근감소증 치료에 새로운 아이디어를 제공하고자 한다.

키워드

근감소증; 인지질 삼인산 3-키나제 (PI3K)/단백질 키나제 B (Akt) 신호 경로; 한약 단일체; 한약 추출물; 한약 복방

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