이전|다음

차이후 계지 감강탕 및 단미 약재 주요 성분의 만성 담낭염 소화불량 치료 연구 진전

  • role： First author第一作者
  • Affiliation：

    School of Clinical Chinese Medicine，Gansu University of Chinese Medicine， Lanzhou 730030，China

  • Email：194691377@qq.com
  • Introduction：杨文文，硕士，住院医师，从事消化系统疾病的中医药防治研究，E-mail：194691377@qq.com
YANG Wenwen1,  
  • role： Corresponding author通信作者
  • Affiliation：

    Diagnosis and Treatment Center of Spleen and Stomach Diseases，Gansu Provincial Hospital of Traditional Chinese Medicine，Lanzhou 730050，China

  • Email：luyubei0618@126.com
  • Introduction：卢雨蓓，硕士，主任医师，从事消化系统疾病的中医药防治研究，E-mail：luyubei0618@126.com； *
LU Yubei2*,  
  • Affiliation：

    School of Clinical Chinese Medicine，Gansu University of Chinese Medicine， Lanzhou 730030，China

CHEN Lin1,  
  • role： Corresponding author通信作者
  • Affiliation：

    Affiliated Hospital of Gansu University of Chinese Medicine，Lanzhou 730030，China

  • Email：17181871@qq.com
  • Introduction：张晶，硕士，副教授，副主任医师，从事消化系统疾病的中医药防治研究，E-mail：17181871@qq.com
ZHANG Jing3*,  
  • Affiliation：

    School of Clinical Chinese Medicine，Gansu University of Chinese Medicine， Lanzhou 730030，China

GAO Ying1,  
  • Affiliation：

    School of Clinical Chinese Medicine，Gansu University of Chinese Medicine， Lanzhou 730030，China

ZHANG Yajuan1,  
  • Affiliation：

    School of Clinical Chinese Medicine，Gansu University of Chinese Medicine， Lanzhou 730030，China

LI Xiaoyan1,  
  • Affiliation：

    School of Clinical Chinese Medicine，Gansu University of Chinese Medicine， Lanzhou 730030，China

YANG Jianfei1,  
  • Affiliation：

    School of Clinical Chinese Medicine，Gansu University of Chinese Medicine， Lanzhou 730030，China

SHI Xiaoli1,  
  • Affiliation：

    School of Clinical Chinese Medicine，Gansu University of Chinese Medicine， Lanzhou 730030，China

LIN Huanhuan1

추상적인

차이후 계지 감강탕은 『상한론』에 처음 기록되었으며, 처방은 차이후, 황금, 계지, 감강, 과루근, 모려, 감초 7가지 약재로 구성되어 있으며 소양을 소통시키고 비위를 따뜻하게 하며 진액을 생성하는 효과가 있다. 임상에서 만성 담낭염(CC), 과민성 대장 증후군, 비알코올성 지방간 등 여러 소화기 질환 치료에 주로 사용된다. CC 소화불량은 CC에 의해 발생하는 복통, 식욕부진, 식후 팽만감, 기름진 음식 기피, 묽은 변, 구취 등 여러 소화기 증상을 포함하는 임상 증후군으로 담원성 소화불량(BD)의 한 형태이다. 현대 의학에서는 내과적 치료와 외과적 치료가 있으며, 내과 치료는 주로 CC의 원발병에 대한 항염증, 담즙분비 촉진, 담석 용해, 진통, 소화 촉진을 위주로 단기적인 치료 효과는 괜찮지만 작용이 단일하며 재발률이 높고 의존성이 부족한 문제점이 있다. 외과 수술은 담낭염의 근치적 치료가 가능하지만 수술 후 복통, 설사, 소화불량 등의 부작용 발생률이 증가한다. 현대 임상 연구에서 차이후 계지 감강탕은 CC 환자의 복통 및 소화불량 증상을 유의하게 개선하는 것으로 확인되었으며, 약리학 연구에서는 차이후 사포닌, 황금 배당체, 계피 알데하이드, 생강올, 쇼가올, 천화분 다당류, 모려 다당류, 감초 총 플라보노이드 등의 성분이 염증 반응 억제, 담낭 수축 기능 및 위장 운동성 개선, 담즙산-장내 미생물 축 조절, 혈중 지질 조절, 뇌-장 축 조절 등의 여러 기전과 다중 표적을 통해 CC 소화불량 증상을 개선함을 발견하였다. 본 논문은 기존 문헌을 회고하여 차이후 계지 감강탕 및 단미 약재 주요 성분의 CC 소화불량 치료 및 CC 소화불량 기전 연구 진전을 종합하였으며, 현재 연구의 부족점과 개선 방안을 제시하여 차이후 계지 감강탕의 CC 소화불량 치료에 대한 향후 연구에 참고가 되고자 한다.

키워드

차이후 계지 감강탕;주요 성분;만성 담낭염;소화불량;종합

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