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Avanços na pesquisa dos mecanismos moleculares dos componentes ativos do Dan Shen contra o câncer colorretal

  • role： First author第一作者
  • Affiliation：

    School of Basic Medical Sciences， Zhejiang Chinese Medical University， Hangzhou 310053，China

    Zhejiang Key Laboratory of Blood-Stasis-Toxin Syndrome， Hangzhou 310053，China

  • Email：15957478520@163.com
  • Introduction：郭嘉宁，在读硕士，从事中医基础理论和中医药抗肿瘤研究，E-mail： 15957478520@163.com
GUO Jianing12,  
  • Affiliation：

    School of Basic Medical Sciences， Zhejiang Chinese Medical University， Hangzhou 310053，China

    Zhejiang Key Laboratory of Blood-Stasis-Toxin Syndrome， Hangzhou 310053，China

NI Xiaochen12,  
  • Affiliation：

    School of Basic Medical Sciences， Zhejiang Chinese Medical University， Hangzhou 310053，China

    Zhejiang Key Laboratory of Blood-Stasis-Toxin Syndrome， Hangzhou 310053，China

ZHANG Kaiyuan12,  
  • Affiliation：

    School of Basic Medical Sciences， Zhejiang Chinese Medical University， Hangzhou 310053，China

    Zhejiang Key Laboratory of Blood-Stasis-Toxin Syndrome， Hangzhou 310053，China

FAN Wei12,  
  • Affiliation：

    School of Basic Medical Sciences， Zhejiang Chinese Medical University， Hangzhou 310053，China

    Zhejiang Key Laboratory of Blood-Stasis-Toxin Syndrome， Hangzhou 310053，China

WANG Chuhang12,  
  • Affiliation：

    School of Basic Medical Sciences， Zhejiang Chinese Medical University， Hangzhou 310053，China

    Zhejiang Cancer Hospital， Hangzhou 310022，China

XU Chao13,  
  • Affiliation：

    School of Basic Medical Sciences， Zhejiang Chinese Medical University， Hangzhou 310053，China

    Zhejiang Key Laboratory of Blood-Stasis-Toxin Syndrome， Hangzhou 310053，China

    Traditional Chinese Medicine ''Preventing Disease'' Wisdom Health Project Research Center of Zhejiang， Hangzhou 310053，China

HUANG Jianbo124,  
  • Affiliation：

    School of Basic Medical Sciences， Zhejiang Chinese Medical University， Hangzhou 310053，China

    Zhejiang Key Laboratory of Blood-Stasis-Toxin Syndrome， Hangzhou 310053，China

    Traditional Chinese Medicine ''Preventing Disease'' Wisdom Health Project Research Center of Zhejiang， Hangzhou 310053，China

JIANG Tao124,  
  • role： Corresponding author通信作者
  • Affiliation：

    School of Basic Medical Sciences， Zhejiang Chinese Medical University， Hangzhou 310053，China

    Zhejiang Key Laboratory of Blood-Stasis-Toxin Syndrome， Hangzhou 310053，China

    Traditional Chinese Medicine ''Preventing Disease'' Wisdom Health Project Research Center of Zhejiang， Hangzhou 310053，China

  • Email：zgjtcm@zcmu.edu.cn
  • Introduction：张光霁，博士，主任医师，教授，从事中医基础理论和中医药抗肿瘤研究，E-mail： zgjtcm@zcmu.edu.cn
ZHANG Guangji124*

Resumo

O câncer colorretal (CRC) é um dos tipos de câncer mais comuns, com alta incidência entre vários tipos de câncer, sendo a segunda principal causa de morte por câncer em todo o mundo. O CRC apresenta falta de sintomas específicos nos estágios iniciais da doença, e a maioria dos pacientes é diagnosticada em estágios intermediários ou avançados, sendo um tema de pesquisa importante na área de tumores do sistema digestivo. Atualmente, o tratamento cirúrgico do CRC apresenta alto risco, com problemas comuns como metástases, recidivas, resistência a medicamentos e efeitos adversos significativos da quimioterapia e radioterapia. Com o desenvolvimento e aplicação da medicina tradicional chinesa, descobriu-se que as ervas chinesas e seus componentes ativos podem inibir efetivamente a proliferação, invasão, migração e angiogênese das células CRC por meio de mecanismos multitarget, multietapa e multifuncionais, promovendo a apoptose e autofagia celular, retardando assim a progressão do CRC, o que é o foco atual das pesquisas de tratamento do CRC. Salvia miltiorrhiza (Dan Shen) possui efeitos de ativação da circulação sanguínea e eliminação de estase, desbloqueio dos meridianos e alívio da dor, purificação do coração e alívio da inquietação, resfriamento do sangue e eliminação de abscessos, contendo diversos componentes químicos, incluindo diterpenos, ácidos fenólicos, flavonoides, polissacarídeos, bem como compostos nitrogenados, esteroides e lactonas. Este artigo revisa os mecanismos moleculares dos componentes ativos do Dan Shen contra o CRC, que atuam por meio de vários mecanismos moleculares, incluindo a inibição do ciclo celular do CRC, promoção da apoptose, inibição da invasão e migração celular, indução da autofagia, supressão da angiogênese tumoral e remodelação do microambiente tumoral, com o objetivo de fornecer novas ideias para o desenvolvimento de medicamentos e para a prática clínica do tratamento do CRC com Dan Shen.

Palavras-chave

Dan Shen;componentes ativos;câncer colorretal;mecanismos moleculares;avanços na pesquisa

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