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Avanços nas pesquisas sobre a intervenção dos componentes ativos e fórmulas da medicina tradicional chinesa na transição epitélio-mesenquimal do câncer de pulmão

  • role： First author第一作者
  • Affiliation：

    Beijing Shijitan Hospital， Capital Medical University， Beijing 100038，China

  • Email：15253063568@163.com
  • Introduction：宋姗姗，硕士，从事中医药防治肿瘤研究，E-mail：15253063568@163.com
SONG Shanshan,  
  • role： Corresponding author通信作者
  • Affiliation：

    Beijing Shijitan Hospital， Capital Medical University， Beijing 100038，China

  • Email：jiangm1965@sina.com
  • Introduction：姜敏，博士，主任医师，教授，博士生导师，从事中医肿瘤学研究，E-mail：jiangm1965@sina.com
JIANG Min*,  
  • Affiliation：

    Beijing Shijitan Hospital， Capital Medical University， Beijing 100038，China

LIU Xinxin,  
  • Affiliation：

    Beijing Shijitan Hospital， Capital Medical University， Beijing 100038，China

HUANG Bozhen,  
  • Affiliation：

    Beijing Shijitan Hospital， Capital Medical University， Beijing 100038，China

MA Siyi,  
  • Affiliation：

    Beijing Shijitan Hospital， Capital Medical University， Beijing 100038，China

WANG Guoyu,  
  • Affiliation：

    Beijing Shijitan Hospital， Capital Medical University， Beijing 100038，China

WANG Wanqing,  
  • Affiliation：

    Beijing Shijitan Hospital， Capital Medical University， Beijing 100038，China

WANG Luyao,  
  • Affiliation：

    Beijing Shijitan Hospital， Capital Medical University， Beijing 100038，China

WANG Liang,  
  • Affiliation：

    Beijing Shijitan Hospital， Capital Medical University， Beijing 100038，China

BO Ruiqing

Resumo

O câncer de pulmão é a principal causa global de mortes relacionadas ao câncer, enquanto a metastase tumoral é o fator chave que leva à morte da maioria dos pacientes com câncer de pulmão. A ativação anormal da transição epitélio-mesenquimal (EMT) é um motor poderoso para o progresso e a metástase das células do câncer de pulmão, caracterizado pela perda da alta diferenciação, polarização e organização das células epiteliais, perda da polaridade ápice-base e adesão celular, aquisição de motilidade, potencial migratório e características invasivas, remodelação do citoesqueleto e transição para um fenótipo mesenquimal, acompanhada por mudanças relacionadas nos marcadores celulares. O processo EMT é extremamente complexo e rigidamente regulado por uma rede complexa que inclui diversos fatores de transcrição, controle pós-traducional, modificações epigenéticas e mediação por RNA não codificante. Portanto, a terapia direcionada aos mecanismos de transformação maligna do câncer de pulmão e seus alvos relacionados tem grande importância clínica. Nos últimos anos, o EMT, como alvo potencial para o tratamento do câncer, tem recebido crescente atenção. A medicina tradicional chinesa possui características únicas, como múltiplos alvos, poucos efeitos adversos e boa eficácia terapêutica, e tem mostrado um papel importante na área anticâncer. Quanto ao papel da medicina tradicional chinesa na inibição do processo EMT no câncer de pulmão, uma série de estudos foram conduzidos. Componentes ativos da medicina tradicional chinesa como flavonoides, glicosídeos, fenóis, terpenos, açúcares, alcaloides, bem como fórmulas tradicionais, possuem efeito regulatório significativo sobre EMT, cujos mecanismos relacionados envolvem principalmente vias de sinalização, exossomos, microRNA (miRNA), microambiente imunológico tumoral, entre múltiplos caminhos, alvos e etapas. O artigo resume os mecanismos pelos quais o EMT promove a progressão maligna do tumor, bem como o estado atual da pesquisa sobre componentes ativos, monômeros e fórmulas da medicina tradicional chinesa que inibem o EMT e, consequentemente, a migração e invasão das células do câncer de pulmão, com o objetivo de fornecer materiais teóricos mais abrangentes para pesquisas básicas e tradução clínica do câncer de pulmão.

Palavras-chave

câncer de pulmão;transição epitélio-mesenquimal;medicina tradicional chinesa;mecanismo;avanços na pesquisa

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