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Avanços na pesquisa do tratamento da doença de Alzheimer com medicina tradicional chinesa

  • role： First author第一作者
  • Affiliation：

    School of Pharmacy， Jiangxi University of Chinese Medicine， Nanchang 330000， China

  • Email：3029288406@qq.com
  • Introduction：徐铮，在读硕士，从事中药学相关研究，E-mail：3029288406@qq.com
XU Zheng1,  
  • Affiliation：

    School of Pharmacy， Jiangxi University of Chinese Medicine， Nanchang 330000， China

    Jiangzhong Pharmaceutical Co. Ltd.， Nanchang 330000， China

TANG Yuan12,  
  • Affiliation：

    Jiangzhong Pharmaceutical Co. Ltd.， Nanchang 330000， China

QIU Fenglan2,  
  • role： Corresponding author通信作者
  • Affiliation：

    School of Pharmacy， Jiangxi University of Chinese Medicine， Nanchang 330000， China

    Jiangzhong Pharmaceutical Co. Ltd.， Nanchang 330000， China

  • Email：lyg@crjz.com
  • Introduction：李诒光，副教授，硕士生导师，从事中药化学与中药药理研究，E-mail：lyg@crjz.com
LI Yiguang12*,  
  • Affiliation：

    Jiangzhong Pharmaceutical Co. Ltd.， Nanchang 330000， China

YANG Lingyu2,  
  • role： Corresponding author通信作者
  • Affiliation：

    School of Pharmacy， Jiangxi University of Chinese Medicine， Nanchang 330000， China

  • Email：19960246@jxutcm.edu.cn
  • Introduction：陈杰，硕士，副教授，硕士生导师，从事中药化学与中药药理研究，E-mail：19960246@jxutcm.edu.cn； *
CHEN Jie1*

Resumo

A doença de Alzheimer (AD) é um tipo comum de demência, caracterizada principalmente por distúrbios cognitivos comportamentais e deficiências de aprendizagem e memória. O desenvolvimento da AD tem causado um enorme fardo econômico para a sociedade e as famílias, mas as causas exatas da doença ainda não foram totalmente esclarecidas. Os medicamentos disponíveis são limitados e geralmente acompanhados de efeitos adversos graves. A medicina tradicional chinesa e seus extratos são principalmente produtos naturais, com múltiplas vias e poucos efeitos colaterais. Alguns experimentos já demonstraram que a medicina tradicional chinesa apresenta grande potencial no tratamento e prevenção da AD, como Huanglian Jiedu Tang, Danggui Shaoyao San, Kaixin San, Liuwei Dihuang Wan, Buyang Huanwu Tang, ginseng, astrágalo, Gou Teng, Huanglian, Gardenia, Ginkgo, Dan Shen, açafrão, entre outros, que podem reduzir a deposição de proteína β-amiloide, inibir a hiperfosforilação da proteína Tau, reparar a função mitocondrial, melhorar o estresse oxidativo, inibir a neuroinflamação e a apoptose, reparar a função sináptica e melhorar a microbiota intestinal. Este artigo resume principalmente os efeitos de algumas medicinas chinesas e suas fórmulas sobre a AD, fornecendo referência para tratamentos futuros com medicina chinesa.

Palavras-chave

doença de Alzheimer;medicina tradicional chinesa;fórmulas da medicina chinesa;mecanismo de ação;neuroinflamação;microbiota intestinal

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