предыдущий|следующий

Прогресс исследований ароматических веществ и их клиническое применение

  • role： First author第一作者
  • Affiliation：

    State Key Laboratory of Bioactive Substances and Function of Natural Medicine，Institute of Materia Medica，Chinese Academy of Medical Sciences and Peking Union Medical College，Beijing 100050，China

  • Email：guoyundan1011@163.com
  • Introduction：郭运丹，在读硕士，从事神经药理学研究，E-mail：guoyundan1011@163.com
GUO Yundan1,  
  • Affiliation：

    Institute of Medicinal Biotechnology，Chinese Academy of Medical Science，Beijing 100050，China

WANG Lulu2,  
  • role： Corresponding author通信作者
  • Affiliation：

    Medicinal Plant Skin Health Research Institute，Beijing Miqi Biotechnology Co. Ltd.，Beijing 100123，China

  • Email：dbrh06@163.com
  • Introduction：张志利，硕士，从事化妆品功效成分研究，E-mail：dbrh06@163.com
ZHANG Zhili3*,  
  • Affiliation：

    Medicinal Plant Skin Health Research Institute，Beijing Miqi Biotechnology Co. Ltd.，Beijing 100123，China

GUO Chen3,  
  • Affiliation：

    Medicinal Plant Skin Health Research Institute，Beijing Miqi Biotechnology Co. Ltd.，Beijing 100123，China

PI Zhihong3,  
  • Affiliation：

    Medicinal Plant Skin Health Research Institute，Beijing Miqi Biotechnology Co. Ltd.，Beijing 100123，China

GONG Wei3,  
  • Affiliation：

    Medicinal Plant Skin Health Research Institute，Beijing Miqi Biotechnology Co. Ltd.，Beijing 100123，China

WU Zongping3,  
  • Affiliation：

    Beijing Feitian Peony BioSciences Co. Ltd.，Beijing 100123，China

WANG Dayu4,  
  • Affiliation：

    State Key Laboratory of Bioactive Substances and Function of Natural Medicine，Institute of Materia Medica，Chinese Academy of Medical Sciences and Peking Union Medical College，Beijing 100050，China

GAO Tianle1,  
  • Affiliation：

    School of Chemical and Environmental Engineering，China University of Mining and Technology，Beijing 100083，China

TIE Cai5,  
  • Affiliation：

    State Key Laboratory of Bioactive Substances and Function of Natural Medicine，Institute of Materia Medica，Chinese Academy of Medical Sciences and Peking Union Medical College，Beijing 100050，China

LIN Yuan1,  
  • Affiliation：

    State Key Laboratory of Bioactive Substances and Function of Natural Medicine，Institute of Materia Medica，Chinese Academy of Medical Sciences and Peking Union Medical College，Beijing 100050，China

    Institute of Medicinal Biotechnology，Chinese Academy of Medical Science，Beijing 100050，China

JIANG Jiandong12

реферат

Ароматерапия – это метод, при котором ароматические компоненты растений используются в подходящих формах для воздействия на весь организм или локально с целью профилактики и лечения заболеваний. Эфирные масла, применяемые в ароматерапии, представляют собой гидрофобные жидкости, содержащие летучие ароматические молекулы. Типичные ароматические молекулы включают лимонен, линалоол, ацетат линалоола, гераниол и цитронеллол. Эти химические вещества были широко исследованы и показали эффективность в снижении тревожности, уменьшении депрессии, улучшении сна и обезболивании. Терпеновые соединения – это небольшие гидрофильные органические молекулы, которые могут проникать через слизистую носа при ингаляции или проникать в кровь через кожу при местном применении. Некоторые из этих веществ способны преодолевать гематоэнцефалический барьер, воздействуя на центральную нервную систему. В настоящее время научное сообщество в целом признает, что эфирные масла и ароматические продукты, полученные из растений, обладают определенными оздоровительными эффектами. Однако процесс выделения отдельного компонента и успешной разработки лекарства все еще сталкивается со многими трудностями, и его безопасность и эффективность требуют более строгих и систематических испытаний. В данной статье систематически изложена эффективность ароматических веществ, включая растительные экстракты и природные малые молекулы, в областях антимикробного, антивирусного и регуляции активности нервной системы, что способствует более глубокому пониманию ароматерапии. Также подробно рассматривается лекарственный потенциал этих ароматических веществ, предоставляя важные ориентиры и идеи для будущих исследований и применения лекарств.

ключеви́че слова́

ароматерапия;эфирные масла;антибактериальные;противовирусные;лекарственная пригодность

References

  1. 1.
    GNATTA J R，KUREBAYASHI L F，TURRINI R N，et al.Aromatherapy and nursing：Historical and theoretical conception［J］.Rev Esc Enferm USP，2016，50（1）：130-136.
  2. 2.
    ZHENG J Y SUI H， MA M G， et al. Research progress on traditional Chinese medicine aromatherapy for insomnia［J］.China's Naturopathy， 2023， 31（2）： 121-125.
  3. 3.
    DE GROOT A C，SCHMIDT E.Essential Oils， Part Ⅲ：Chemical Composition［J］.Dermatitis，2016，27（4）：161-169.
  4. 4.
    CHEONG M J，KIM S，KIM J S，et al.A systematic literature review and Meta-analysis of the clinical effects of aroma inhalation therapy on sleep problems［J］.Medicine （Baltimore），2021，100（9）：e24652.
  5. 5.
    SMITH C A，LEVETT K M，COLLINS C T，et al.Massage，reflexology and other manual methods for pain management in labour［J］.Cochrane Database Syst Rev，2018，3（3）：CD009290.
  6. 6.
    LIU T T，CHENG H，TIAN L，et al.Aromatherapy with inhalation can effectively improve the anxiety and depression of cancer patients：A Meta-analysis［J］.Gen Hosp Psychiatry，2022，77：118-127.
  7. 7.
    SCHNEIDER R，SINGER N，SINGER T.Medical aromatherapy revisited：Basic mechanisms，critique，and a new development［J］.Hum Psychopharmacol，2019，34（1）：e2683.
  8. 8.
    CUI J Q，LI M，WEI Y Y，et al.Inhalation aromatherapy via brain-targeted nasal delivery：Natural volatiles or essential oils on mood disorders［J］.Front Pharmacol，2022，13：860043.
  9. 9.
    BORA H，KAMLE M，MAHATO D K，et al.Citrus essential oils（CEOs） and their applications in food：An overview［J］.Plants （Basel），2020，9（3）：357.
  10. 10.
    AMBROSIO C M S，ALVIM I D，WEN C F，et al.Exploring the effect of a microencapsulated Citrus essential oil on in vitro fermentation kinetics of pig gut microbiota［J］.Front Microbiol，2022，13：952706.
  11. 11.
    YU L H，YAN J，SUN Z G.D-limonene exhibits anti-inflammatory and antioxidant properties in an ulcerative colitis rat model via regulation of iNOS，COX-2，PGE2 and ERK signaling pathways［J］.Mol Med Rep，2017，15（4）：2339-2346.
  12. 12.
    HUDZ N，KOBYLINSKA L，POKAJEWICZ K，et al.Mentha piperita：Essential oil and extracts，their biological activities，and perspectives on the development of new medicinal and cosmetic products［J］.Molecules，2023，28（21）：7444.
  13. 13.
    ZHAO H，REN S，YANG H，et al.Peppermint essential oil：Its phytochemistry，biological activity，pharmacological effect and application［J］.Biomed Pharmacother，2022，154：113559.
  14. 14.
    YEUNG K S，HERNANDEZ M，MAO J J，et al.Herbal medicine for depression and anxiety：A systematic review with assessment of potential psycho-oncologic relevance［J］.Phytother Res，2018，32（5）：865-891.
  15. 15.
    WIŃSKA K，MĄCZKA W，ŁYCZKO J，et al.Essential oils as antimicrobial agents：Myth or real alternative？［J］.Molecules，2019，24（11）：2130.
  16. 16.
    PREMKUMAR K S，AAFAQUE S，SUMALATHA S，et al.Effect of aromatherapy on dental anxiety among orthodontic patients：A randomized controlled trial［J］.Cureus，2019，11（8）：e5306.
  17. 17.
    SODEN K，VINCENT K，CRASKE S，et al.A randomized controlled trial of aromatherapy massage in a hospice setting［J］.Palliat Med，2004，18（2）：87-92.
  18. 18.
    PAN X，WANG K Z，LU C，et al.Protective effect of lavender oil on scopolamine induced cognitive deficits in mice and H2O2 induced cytotoxicity in PC12 cells［J］.J Ethnopharmacol，2016，193：408-415.
  19. 19.
    SHIRAZI M，MOHEBITABAR S，BIOOS S，et al.The effect of topical rosa damascena （rose） oil on pregnancy-related low back pain：A randomized controlled clinical trial［J］.J Evid Based Complementary Altern Med，2017，22（1）：120-126.
  20. 20.
    HAMMER K A.Treatment of acne with tea tree oil （Melaleuca） products：A review of efficacy，tolerability and potential modes of action［J］.Int J Antimicrob Agents，2015，45（2）：106-110.
  21. 21.
    LAM N S，LONG X，SU X Z，et al.Melaleuca alternifolia （tea tree） oil and its monoterpene constituents in treating protozoan and helminthic infections［J］.Biomed Pharmacother，2020，130：110624.
  22. 22.
    CHA H，KIM S，SEO M S，et al.Effects of olfactory stimulation on cognitive function and behavior problems in older adults with dementia：A systematic literature review［J］.Geriatr Nurs，2021，42（5）：1210-1217.
  23. 23.
    YAP W S，DOLZHENKO A V，JALAL Z，et al.Efficacy and safety of lavender essential oil （Silexan） capsules among patients suffering from anxiety disorders：A network Meta-analysis［J］.Sci Rep，2019，9（1）：18042.
  24. 24.
    FRIEDLAND K，SILANI G，SCHUWALD A，et al.Neurotrophic properties of silexan，an essential oil from the flowers of lavender-preclinical evidence for antidepressant-like properties［J］.Pharmacopsychiatry，2021，54（1）：37-46.
  25. 25.
    REYES-JURADO F，NAVARRO-CRUZ A R，OCHOA-VELASCO C E，et al.Essential oils in vapor phase as alternative antimicrobials：A review［J］.Crit Rev Food Sci Nutr，2020，60（10）：1641-1650.
  26. 26.
    BEN LAGHA A，VAILLANCOURT K，MAQUERA HUACHO P，et al.Effects of labrador tea，peppermint，and winter savory essential oils on fusobacterium nucleatum［J］.Antibiotics （Basel），2020，9（11）：794.
  27. 27.
    VALDIVIESO-UGARTE M，GOMEZ-LLORENTE C，PLAZA-DÍAZ J，et al.Antimicrobial，antioxidant，and immunomodulatory properties of essential oils：A systematic review［J］.Nutrients，2019，11（11）：2786.
  28. 28.
    ROY R，TIWARI M，DONELLI G，et al.Strategies for combating bacterial biofilms：A focus on anti-biofilm agents and their mechanisms of action［J］.Virulence，2018，9（1）：522-554.
  29. 29.
    ASHRAFUDOULLA M，MEVO S I U，SONG M S，et al.Antibiofilm mechanism of peppermint essential oil to avert biofilm developed by foodborne and food spoilage pathogens on food contact surfaces［J］.J Food Sci，2023，88（9）：3935-3955.
  30. 30.
    SPRENGER S，WOLDEMARIAM T，KOTCHONI S，et al.Lemongrass essential oil and its major constituent citral isomers modulate adipogenic gene expression in 3T3-L1 cells［J］.J Food Biochem，2022，46（2）：e14037.
  31. 31.
    BURT S A，VLIELANDER R，HAAGSMAN H P，et al.Increase in activity of essential oil components carvacrol and thymol against Escherichia coli O157：H7 by addition of food stabilizers［J］.J Food Prot，2005，68（5）：919-926.
  32. 32.
    WIJESUNDARA N M，VASANTHA R H.Essential oils from Origanum vulgare and Salvia officinalis exhibit antibacterial and anti-biofilm activities against Streptococcus pyogenes［J］.Microb Pathog，2018，117：118-127.
  33. 33.
    KASKATEPE B，ASLAN E S，OZTURK S，et al.Antifungal and Anti-virulent activity of origanum majorana l.essential Oil on candida albicans and in vivo toxicity in the Galleria mellonella larval model［J］.Molecules，2022，27（3）：663.
  34. 34.
    YU D，WANG J，SHAO X，et al.Antifungal modes of action of tea tree oil and its two characteristic components against Botrytis cinerea［J］.J Appl Microbiol，2015，119（5）：1253-1262.
  35. 35.
    SHAO X，CHENG S，WANG H，et al.The possible mechanism of antifungal action of tea tree oil on Botrytis cinerea［J］.J Appl Microbiol，2013，114（6）：1642-1649.
  36. 36.
    MAHANT S，SAHAJPAL N S，NANDA S J.Insights into the mechanism of cymbopogan martinii essential oil in topical therapy of acne vulgaris［J］.Future Microbiol，2021，16：1181-1193.
  37. 37.
    GAO X，LIU J B，LI B，et al.Antibacterial activity and antibacterial mechanism of lemon verbena essential oil［J］.Molecules，2023，28（7）：3102.
  38. 38.
    EBADI M T，SEFIDKON F，AZIZI M，et al.Packaging methods and storage duration affect essential oil content and composition of lemon Verbena （Lippia citriodora Kunth.）［J］.Food Sci Nutr，2017，5（3）：588-595.
  39. 39.
    HUANG J H，QIAN C，XU H J，et al.Antibacterial activity of Artemisia asiatica essential oil against some common respiratory infection causing bacterial strains and its mechanism of action in Haemophilus influenzae［J］.Microb Pathog，2018，114：470-475.
  40. 40.
    XU J G，LIU T，HU Q P，et al.Chemical composition，antibacterial properties and mechanism of action of essential oil from clove buds against Staphylococcus aureus［J］.Molecules，2016，21（9）：1194.
  41. 41.
    KANG J M，LIU L，WU X X，et al.Effect of thyme essential oil against Bacillus cereus planktonic growth and biofilm formation［J］.Appl Microbiol Biotechnol，2018，102（23）：10209-10218.
  42. 42.
    JIANG Y，WU N，FU Y J，et al.Chemical composition and antimicrobial activity of the essential oil of rosemary［J］.Environ Toxicol Pharmacol，2011，32（1）：63-68.
  43. 43.
    KAFA A H T，ASLAN R，CELIK C，et al.Antimicrobial synergism and antibiofilm activities of Pelargonium graveolens，Rosemary officinalis，and Mentha piperita essential oils against extreme drug-resistant Acinetobacter baumannii clinical isolates［J］.Z Naturforsch C J Biosci，2022，77（3/4）：95-104.
  44. 44.
    RASOOLI I，SHAYEGH S，ASTANEH S.The effect of Mentha spicata and Eucalyptus camaldulensis essential oils on dental biofilm［J］.Int J Dent Hyg，2009，7（3）：196-203.
  45. 45.
    LIU Q，GAO Y，FU X，et al.Preparation of peppermint oil nanoemulsions：Investigation of stability，antibacterial mechanism and apoptosis effects［J］.Colloids Surf B Biointerfaces，2021，201：111626.
  46. 46.
    TROSZOK A，ROSZKO M.Thyme essential oil inhibits intracellular replication of CyHV-3 and inactivates extracellular virus.An in vitro study［J］.J Fish Dis，2023，46（6）：663-677.
  47. 47.
    CIVITELLI L，PANELLA S，MARCOCCI M E，et al.In vitro inhibition of herpes simplex virus type 1 replication by Mentha suaveolens essential oil and its main component piperitenone oxide［J］.Phytomedicine，2014，21（6）：857-865.
  48. 48.
    LYU X N，LIU Z J，ZHANG H J，et al.Aromatherapy and the central nerve system （CNS）：Therapeutic mechanism and its associated genes［J］.Curr Drug Targets，2013，14（8）：872-879.
  49. 49.
    LIE G，WILSON A，CAMPION T，et al.What's that smell？ A pictorial review of the olfactory pathways and imaging assessment of the myriad pathologies that can affect them［J］.Insights Imag，2021，12（1）：7.
  50. 50.
    LÓPEZ-ELIZALDE R，CAMPERO A，SÁNCHEZ-DELGADILLO T，et al.Anatomy of the olfactory nerve：A comprehensive review with cadaveric dissection［J］.Clin Anat，2018，31（1）：109-117.
  51. 51.
    LOCKER P，PLITT M，PAPAGIANNOPOULOS P，et al.Anatomic relationship of the first olfactory neuron and trochlea：Cadaveric study with surgical implications［J］.Int Forum Allergy Rhinol，2017，7（11）：1085-1088.
  52. 52.
    KIECOLT-GLASER J K，GRAHAM J E，MALARKEY W B，et al.Olfactory influences on mood and autonomic，endocrine，and immune function［J］.Psychoneuroendocrinology，2008，33（3）：328-339.
  53. 53.
    CHIOCA L R，FERRO M M，BARETTA I P，et al.Anxiolytic-like effect of lavender essential oil inhalation in mice：Participation of serotonergic but not GABAA/benzodiazepine neurotransmission［J］.J Ethnopharmacol，2013，147（2）：412-418.
  54. 54.
    ZHONG Y，ZHENG Q，HU P Y，et al.Sedative and hypnotic effects of compound Anshen essential oil inhalation for insomnia［J］.BMC Complement Altern Med，2019，19（1）：306.
  55. 55.
    XU Y，MA L，LIU F，et al.Lavender essential oil fractions alleviate sleep disorders induced by the combination of anxiety and caffeine in mice［J］.J Ethnopharmacol，2023，302（Pt A）：115868.
  56. 56.
    LóPEZ V，NIELSEN B，SOLAS M，et al.Exploring pharmacological mechanisms of lavender （Lavandula angustifolia） essential oil on central nervous system targets［J］.Front Pharmacol，2017，8：280.
  57. 57.
    SASAKI K，FERDOUSI F，FUKUMITSU S，et al.Antidepressant- and anxiolytic-like activities of Rosmarinus officinalis extract in rodent models：Involvement of oxytocinergic system［J］.Biomed Pharmacother，2021，144：112291.
  58. 58.
    AGATONOVIC-KUSTRIN S，KUSTRIN E，MORTON D W.Essential oils and functional herbs for healthy aging［J］.Neural Regen Res，2019，14（3）：441-445.
  59. 59.
    HU B， WANG D B， GUO M.Effects of ligustrazine on analgesic effect and neuronal damage in migraine rats by regulating SIRT1/AMPK/PGC1α signaling pathway ［J］.Tianjin Med J， 2023， 51（4）： 382-387.
  60. 60.
    PENG C，XIE X F，WANG L，et al.Pharmacodynamic action and mechanism of volatile oil from Rhizoma Ligustici Chuanxiong Hort.on treating headache［J］.Phytomedicine，2009，16（1）：25-34.
  61. 61.
    DEMIREL S.Rosa damascena Miller essential oil relaxes rat thoracic aorta through the NO-cGMP-dependent pathway［J］.Prostaglandins Other Lipid Mediat，2022，162：106661.
  62. 62.
    XIA N，WANG J，GUO Q T，et al.Deciphering the antidepressant effects of Rosa damascena essential oil mediated through the serotonergic synapse signaling pathway［J］.J Ethnopharmacol，2024，328：118007.
  63. 63.
    MUHAMMAD F，LIU Y，WANG N B，et al.Rose essential oil diminishes dopaminergic neuron degenerations and reduces α-synuclein aggregation in Caenorhabditis elegans models of Parkinson's disease［J］.Phytother Res，2023，37（7）：2877-2893.
  64. 64.
    ZHONG Y，ZHENG Q，HU P Y，et al.Sedative and hypnotic effects of Perilla frutescens essential oil through GABAergic system pathway［J］.J Ethnopharmacol，2021，279：113627.
  65. 65.
    FARAG M R，ZHENG C T，GHARIB H S A，et al.Physiological and neurobehavioral disturbances induced by Al2O3 nanoparticle intoxication in nile tilapia fish：Benefits of dietary chamomile essential oil［J］.Aquac Nutr，2023，2023：6700708.
  66. 66.
    HASHIKAWA-HOBARA N，OTSUKA A，ISHIKAWA R，et al.Roman chamomile inhalation combined with clomipramine treatment improves treatment-resistant depression-like behavior in mice［J］.Biomed Pharmacother，2019，118：109263.
  67. 67.
    YUAN R F，ZHANG D K，YANG J H，et al.Review of aromatherapy essential oils and their mechanism of action against migraines［J］.J Ethnopharmacol，2021，265：113326.
  68. 68.
    HEDIGAN F，SHERIDAN H，SASSE A.Benefit of inhalation aromatherapy as a complementary treatment for stress and anxiety in a clinical setting - a systematic review［J］.Complement Ther Clin Pract，2023，52：101750.
  69. 69.
    RAMBOD M，RAKHSHAN M，TOHIDINIK S，et al.The effect of lemon inhalation aromatherapy on blood pressure，electrocardiogram changes，and anxiety in acute myocardial infarction patients：A clinical，multi-centered，assessor-blinded trial design［J］.Complement Ther Clin Pract，2020，39：101155.d
  70. 70.
    HEYDARI A，HOSSEINI S，VAKILI M，et al.Effect of lavender essence inhalation on the level of anxiety and blood Cortisol in candidates for open-heart surgery［J］.Iran J Nurs Midwifery Res，2016，21（4）：397-401.
  71. 71.
    PASYAR N，RAMBOD M，ARAGHI F.The effect of bergamot orange essence on anxiety，salivary Cortisol，and alpha amylase in patients prior to laparoscopic cholecystectomy：A controlled trial study［J］.Complement Ther Clin Pract，2020，39：101153.
  72. 72.
    GONG M M，DONG H，TANG Y H，et al.Effects of aromatherapy on anxiety：A Meta-analysis of randomized controlled trials［J］.J Affect Disord，2020，274：1028-1040.
  73. 73.
    SUN J B，LI H，SUN J H，et al.Chemical composition and antimigraine activity of essential oil of Angelicae Dahuricae Radix［J］.J Med Food，2017，20（8）：797-803.
  74. 74.
    DOSOKY N S，SETZER W N.Biological activities and safety of citrus spp.essential oils［J］.Int J Mol Sci，2018，19（7）：1966.
  75. 75.
    KEMPER K J.Special issue on aromatherapy：A low cost，low risk，complementary environmental therapy［J］.Complement Ther Med，2020，52：102471.
  76. 76.
    PDQ I A，COMPLEMENTARY T E B.Topics in Integrative，alternative，and complementary therapies （PDQ®）：Health professional version［M］.PDQ Cancer Information Summaries.Bethesda （MD）； National Cancer Institute （US）.2002.

Читать полностью

The above content is generated by Large Model Translation. The translated content is for reference only. We do not assume any commercial or legal responsibilty for any consequences arising from the use of our website