предыдущий|следующий

Хроническая сердечная декомпенсация, апоптоз миокардиальных клеток и вмешательство традиционной китайской медицины

  • role： First author第一作者
  • Affiliation：

    Hunan University of Chinese Medicine， Changsha 410208， China

  • Email：2803146053@qq.com
  • Introduction：廉坤，在读博士，从事心血管疾病证本质与诊治规律研究，E-mail：2803146053@qq.com
LIAN Kun,  
  • Affiliation：

    Hunan University of Chinese Medicine， Changsha 410208， China

LI Peiyao,  
  • Affiliation：

    Hunan University of Chinese Medicine， Changsha 410208， China

SONG Zhiguang,  
  • Affiliation：

    Hunan University of Chinese Medicine， Changsha 410208， China

ZHANG Jianhang,  
  • Affiliation：

    Hunan University of Chinese Medicine， Changsha 410208， China

LEI Junxian,  
  • Affiliation：

    Hunan University of Chinese Medicine， Changsha 410208， China

LI Lin,  
  • role： Corresponding author通信作者
  • Affiliation：

    Hunan University of Chinese Medicine， Changsha 410208， China

  • Email：003405@hnucm.edu.cn
  • Introduction：胡志希，教授，博士，博士生导师，从事心血管疾病证候本质与诊治规律研究，E-mail：003405@hnucm.edu.cn
HU Zhixi*

реферат

Хроническая сердечная недостаточность является конечным этапом различных сердечно-сосудистых заболеваний, а апоптоз миокардиальных клеток является точкой перегиба в прогрессировании сердечной недостаточности. Исследования показывают, что традиционная китайская медицина может регулировать апоптотические сигнальные пути и факторы апоптоза, подавляя или повышая связанные с апоптозом белки. Это позволяет уменьшить апоптоз миокарда, защитить мышечную ткань сердца и улучшить его функцию, что демонстрирует значительные клинические результаты. В последние годы увеличилось количество исследований, основанных на подавлении апоптоза миокардиальных клеток в качестве лечения хронической сердечной недостаточности, что является актуальной темой исследований. В настоящем обзоре с использованием литературого анализа, исследование показывает, что традиционная китайская медицина основным образом регулирует факторы апоптоза и апоптотические сигнальные пути, связанные с классическими путями рецепторной умеренности, митохондриальным маршрутом и тупиковым эндоплазматическим путем. Исследование также показывает, что существует ряд проблем в этой области, таких как частая повторная тема и поверхностный, однообразный и фрагментированный характер исследований. Большинство исследований аналогично наличию только одной концентрации препарата, что недостаточно объяснить его эффект. В области недостаток обширных, комплексных и системных исследований в области апоптоза клеток в ответ на воспалительные реакции, программированный некроз клеток, железный некроз и аутофагия клеток. В будущем необходимо разработать более научный, логичный, комплексный и выполнимый экспериментальный план на основе всеобъемлющих и комплексных исследований в этой области, усилить сотрудничество и взаимодействие междисциплинарных исследователей; разъяснить конкретные патологические механизмы апоптоза клеток при хронической сердечной недостаточности, полностью объяснить сигнальные пути, эффективные компоненты традиционной китайской медицины и целевые точки действия для угнетения апоптоза миокардиальных клеток при хронической сердечной недостаточности.

ключеви́че слова́

Хроническая сердечная недостаточность; традиционная китайская медицина; апоптоз миокарда; рецепторная умеренность

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