предыдущий|следующий

Прогресс в исследованиях лечебных эффектов и механизма действия барсучьего одёра в лечении инсульта

  • role： First author第一作者
  • Affiliation：

    School of Basic Medical Sciences， Hengyang Medical School， University of South China， Hengyang 421001， China

  • Email：1971809250@qq.com
  • Introduction：严易之，在读硕士，从事中药神经药理学的研究，E-mail：1971809250@qq.com
YAN Yizhi1,  
  • Affiliation：

    School of Basic Medical Sciences， Hengyang Medical School， University of South China， Hengyang 421001， China

LIU Xinyi1,  
  • Affiliation：

    School of Basic Medical Sciences， Hengyang Medical School， University of South China， Hengyang 421001， China

DUAN Yang1,  
  • Affiliation：

    School of Basic Medical Sciences， Hengyang Medical School， University of South China， Hengyang 421001， China

LONG Miaoqing1,  
  • Affiliation：

    Chenzhou No.1 People's Hospital， Chenzhou 423000， China

LI Chaoya2,  
  • Affiliation：

    School of Basic Medical Sciences， Hengyang Medical School， University of South China， Hengyang 421001， China

LI Qiang1,  
  • Affiliation：

    School of Basic Medical Sciences， Hengyang Medical School， University of South China， Hengyang 421001， China

CHEN Yi'an1,  
  • Affiliation：

    School of Basic Medical Sciences， Hengyang Medical School， University of South China， Hengyang 421001， China

YANG Shasha1,  
  • role： Corresponding author通信作者
  • Affiliation：

    School of Basic Medical Sciences， Hengyang Medical School， University of South China， Hengyang 421001， China

  • Email：2021000048@usc.edu.cn
  • Introduction：张月，博士，讲师，从事中药药理学研究，E-mail：2021000048@usc.edu.cn
ZHANG Yue1*,  
  • role： Corresponding author通信作者
  • Affiliation：

    School of Basic Medical Sciences， Hengyang Medical School， University of South China， Hengyang 421001， China

  • Email：zengp@usc.edu.cn
  • Introduction：曾鹏，博士，校聘教授，从事中药神经药理学研究，E-mail：zengp@usc.edu.cn； *
ZENG Peng1*

реферат

Инсульт является основной причиной смертности и инвалидности среди взрослых в нашей стране, он отличается высокой заболеваемостью, высоким уровнем инвалидности, высокой смертностью и частотой рецидивов. У него огромный потенциал в лечении инсульта и его поздних проявлений в китайской и западной медицине, он успешно используется в традиционной китайской медицине в лечении инсульта и его поздних проявлений уже давно. Значительное количество барсучьего одёра часто используется в клинике для лечения инсульта и его поздних проявлений, но количество и качество клинических испытаний барсучьего одёра для лечения инсульта требует улучшения, и в то же время слабы исследования в области основ, неизвестно, эффективные компоненты, механизм действия с несколькими целями не ясен. Недавно проведенное исследование группы показало, что барсучий одёр может эффективно обратить утрату нейронной функции крыс с геморрагическим инсультом, уменьшить осадка железа, снизить уровень цитокинов противовоспалительных факторов, его механизм связан с путем сигнала, посредством ядра перевернутого 2 регулируемого фактора (Nrf2), и путем сигнала активации белка митоза 38 (MAPK) посредством активации микроглии. Чтобы раскрыть лекарственную основу барсучьего одёр и механизм действия против инсульта, данная статья обобщает лечение инсульта барсучьего одёра в клинических исследованиях, лекарственные компоненты, оценку безопасности и прогресс исследований для понимания механизма лечения поздних проявлений инсульта. Эта статья собрала 45 основных химических соединений растений барсучьего одёра, 11 из которых известны как компоненты крови на данный момент, среди них ризома, эмпирен, флавоноид, лист алоэ, империвилин, апельсиновый гликозид, грейпфрутовый гликозид, темный порошок, и темный порошок могут выступать в качестве маркеров качества барсучьего одёра. Механизм лечения инсульта барсучьего одёра сложен, включая регулирование воспалительных реакций, повреждение нейронов, окислительный стресс, гематоэнцефалический барьер, нейротрофические факторы, агрегацию тромбоцитов и т. Д. Эта статья способствует глубокому пониманию лекарственной основы барсучьего одёра и механизма действия в лечении инсульта, обеспечивает теоретическую основу для применения лечения барсучьего одёра в лечении инсульта и разработки противоинсультных препаратов.

ключеви́че слова́

Барсучий одёр, инсульт, лекарственная основа, маркеры качества (Q-Marker), механизм действия

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