Воздействие уточненного желчного жаропонижающего препарата на уровни 5-HT в крови, MT, TNF-αи уровни половых гормонов у пациентов с влажно-жарким бессонницей в перименопаузе

  • role: First author第一作者
  • Affiliation:

    The First Affiliated Hospital of Nanjing Medical University, Nanjing 210000, China

  • Email:wangywyan87@163.com
  • Introduction:E-mailwangywyan87@163.com
WANG Yan1,  
  • Affiliation:

    Nanjing Changjiang Hospital, Nanjing 210000, China

XU Yuexia2,  
  • role: Corresponding author通信作者
  • Affiliation:

    The First Affiliated Hospital of Nanjing Medical University, Nanjing 210000, China

  • Email:dr.wding@163.com
  • Introduction:西E-maildr.wding@163.com
DING Wei1*

реферат

Цель исследования заключалась в изучении прикладной ценности уточненного желчного жаропонижающего препарата в лечении пациентов с влажно-жарким бессонницы в перименопаузе, и наблюдение за его влиянием на нервные передачи и жировую ткань. Метод: Включила 162 случая пациентов с влажно-жаркой бессонницей в перименопаузе, которые были лечены в отделении традиционной китайской медицины Первой прикрепленной больницы медицинского университета Нанкин c мая 2021 по ноябрь 2023 года. Все они были случайно распределены до исследования. В контрольной группе 81 случай были лечены стандартной западной медициной, и в наблюдательной группе 81 случай были лечены уточненным желчным жаропонижающим препаратом совместно, лечение продолжалось 4 недели. Результаты: По сравнению с лечением в этой группе, после лечения были снижены уровни лейкоцитов и интерлейкина-1β (IL-1β), фактора некроза опухоли-альфа (TNF-α) в крови, увеличены уровни дофамина (DA), мелатонина (MT), серотонина (5-HT) (p<0.05)...

ключеви́че слова́

Уточненный желчный жаропонижающий препарат; перименопауза; влажный жар; нервные передачи; мелатонин (MT); фактор некроза опухоли-альфа (TNF-α); половые гормоны; качество сна

References

  1. 1.
    LI S Y, ZHANG B. Research status and prospect of insomnia disorder [J]. J Pract Med,2024,40(6):731-737.
  2. 2.
    ZHAO Y H, LUO X. Research progress on the epidemiology and pathogenesis of insomnia [J]. Chin J Clin,2023, 51(12):1397-1401.
  3. 3.
    CHANG Z F, LUO J Y, WANG Y T, et al. TCM clinical retrospective analysis of 149 young female patients with chronic insomnia [J]. J Shanxi Univ Tradit Chin Med, 2021,23(6):549-553.
  4. 4.
    ZHANG Q, LIU X M, ZHANG M K. Pathogenesis and treatment progress of perimenopausal insomnia [J]. Acad J Chin PLA Med Sch,2023,44(9):1056-1059.
  5. 5.
    SHENG S Q, DONG S Y, FAN M M, et al. Efficacy of Kun'anle decoction combined with femoston in the treatment of perimenopausal women with sleep disorder:A randomized controlled trial [J]. Chin J Integr Tradit West Med, 2024,44(1):25-30.
  6. 6.
    XIE Y C, YE X L. Analysis of prescription rules of traditional Chinese medicine in the treatment of non-organic insomnia [J]. J China Prescrip Drug,2024, 22(4):169-172.
  7. 7.
    WANG B H, CAI J, ZHANG Y H. Effect of estradiol tablets/estradiol and dydrogesterone tablets combined with psychological intervention on perimenopausal patients with anxiety and depression [J]. J Internat Psych, 2024,51(2):548-551,556.
  8. 8.
    CHEN Y F, LU J, ZHOU Z M. Clinical effect of estradiol tablets/estradiol dexmedroxyprogesterone tablets combined with psychological intervention treatment on perimenopausal women with anxiety and depression [J]. Mod Dist Edu Chin Tradit Med,2018,16(3):59-62.
  9. 9.
    ZHANG P, LI Y P, WU H J, et al. Chinese guidelines for the diagnosis and treatment of insomnia in adults (2017 edition)[J]. Chin J Neurol,2018,51(5):324-335.
  10. 10.
    ZHENG X Y. Clinical Guidelines for New Drugs of Traditional Chinese Medicine[M]. Beijing: China Medical Science and Technology Press,2002:162-167.
  11. 11.
    MI X J,FANG J N,YU X Y,et al Clinical efficacy of Zishui Bugan decoction on perimenopausal insomnia patients with liver-kidney deficiency [J]. Chin J Exp Tradit Med Form, 2012,28(16):116-122
  12. 12.
    WANG Y X, TANG L, SUN T L, et al. Effects of Gengxin Tang on serum estrogen levels and hypothalamic estrogen receptors in a perimenopausal insomnia model in rat [J]. China J Tradit Chin Med Pharm,2024,39(1):147-151.
  13. 13.
    MO M S, REN C F, LU Y H. Effect of Chaishao Yangxue Jieyu decoction on sleep quality and serum sex hormone levels in perimenopausal patients with insomnia [J].J Guangxi Univ Chin Med,2024,27(3):17-20.
  14. 14.
    LI W H, XIE W Y, WU C J, et al. Network meta⁃analysis of Chinese patent medicine combined with conventional western medicine in treatment of emotional disorder in perimenopausal women [J]. J Hainan Med Univ, 2020,8(5):1-39.
  15. 15.
    JI X J, WANG Y B, LI F, et al. Research on main active components of Ⅳ Fructus Ligustri Lucidi-Ecliptae Herba' drug pair based on network pharmacology [J]. Chin Contem Med,2020,27(12):12-15.
  16. 16.
    CHEN J, LI J, GUAN X, et al. Effects of traditional Chinese herbal formula on tongue image metrics in different
  17. 17.
    CAI S W, FAN B S, SONG X J, et al. Research progress of pharmacological action and clinical application of mineral traditional Chinese medicine in the treatment of insomnia [J]. Tianjin J Tradit Chin Med,2024,41(3):403-408.
  18. 18.
    HAN Y Y, WU X L, LI X C, et al. Evaluation of the therapeutic effect of abdominal acupuncture combined with Tiaoshen Jieyu acupuncture in the treatment of patients with perimenopausal insomnia based on 5-HT, DA, NE, 5-HIAA and sleep quality [J]. Jilin J Chin Med,2023,43(6):728-732.
  19. 19.
    LI Y , HUI P L. Efficacy of Bupleurum plus dragon bone and oyster shell decoction combined with auricular point pressing bean in the treatment of perimenopausal insomnia (kidney deficiency and liver depression type) and influence on serum 5-hydroxytryptamine, dopamine level, and sleep quality [J]. Hainan Med,2021,32(24):3166-3169.
  20. 20.
    WEI X C, LU J, LI J, et al. Influence of Tongue acupuncture combined with body acupuncture to sex hormone levels and sleep quality in patients with perimenopausal insomnia: A randomized controlled trial [J]. Clin J Acupunct Moxibust,2024,40(4):11-15.
  21. 21.
    WANG J F, WANG D H. Effect of modified Chaihujia-Longgu-Muli decoction on sleep quality, negative emotions and endocrine hormones in perimenopausal patients with insomnia [J]. Mod J Integr Tradit Chin West Med, 22,31(13):1842-1845.
  22. 22.
    YAN S Q, WANG D, ZHANG X, et al. Clinical efficacy of traditional Chinese medicine for soothing liver and strengthening spleen combined with probiotics in the treatment of insomnia and its effect on serum levels of 5-hydroxytryptamine, melatonin and vasoactive intestinal peptide [J]. Tianjin J Tradit Chin Med,2024,41(3):287-293.
  23. 23.
    LIN R Y, WU L, ZHAO J. Clinical effect of acupuncture of Yinqi Guiyuan combined with moxibustion of Yongquan acupoint on patients with perimenopausal insomnia and effect on serum interleukin-1β,5-HT,FSH [J]. Shaanxi Tradit Chin Med,2020,41(6):811-814.
  24. 24.
    WANG J, TUO J. Effect of modified Chaihu Wenjing decoction on sleep quality and inflammatory factors in perimenopausal patients with insomnia of liver depression and Yin deficiency and blood stasis [J]. Jilin Med,2023,44(8):2248-2251.
  25. 25.
    CHEN J B. The improvement of insomnia,anxiety and depression in perimenopausal period and the influence on sleep quality by the acupuncture and moxibustion program of soothing the liver and regulating menstruation combined with ear point embedding beans [J]. World J Sleep Med, 2020,11(2):278-281.
  26. 26.
    LIN W X, ZHOU J H, HAN Y Y. Effect of acupuncture and moxibustion combined with Qingre-Anshen decoction on sleep quality of perimenopausal insomnia patients with phlegm-heat internal disturbance [J]. J Sichuan Tradit Chin Med, 2012,40(6):164-167.
  27. 27.
    SHI L L, CHEN L M, CHEN L. Clinical observation on modified Chaihu Wenjing decoction in treatment of refractory insomnia of liver depression, Yin deficiency and blood stasis type during perimenopause [J]. J Hubei Univ Tradit Chin Med, 24,26(3):76-78.
  28. 28.
    GUO J H, GONG Y, LI Y H, et al. Effect of Jiawei Xiaoyao pill and Kunbao pill on insomnia in perimenopausal syndrome [J]. Liaoning J Tradit Chin Med,2024,51(6):89-92.
  29. 29.
    XU B, WANG P XIA J, et al. Anmeidan regulates hepatic neurotransmitters and circadian rhythm in rat model of insomnia via OX1R/PLCβ-1/PKCα/ERK1/2 signaling pathway [J]. Chin J Exp Tradit Med Form,2024,30(15):11-20.
  30. 30.
    LI Y S, LUAN Y F, LIU K L, et al. Research progress on the mechanism of traditional Chinese medicine in the treatment of perimenopausal depression by regulating different signaling pathways [J]. Jiangsu Tradit Chin Med, 2020,56(5):77-81
  31. 31.
    ZHU J, XU L W, LI K Q, et al. Pathogenesis of perimenopausal depression and prevention and treatment bytraditional Chinese medicine: A review [J]. Chin J Exp Tradit Med Form, 24,9(5):1-13.
  32. 32.
    XU J. Clinical effect of Wendan decoction combined with scalp acupuncture on perimenopausal insomnia with phlegm-heat type [D]. Nanchang: Jiangxi University of Traditional Chinese Medicine,2023.
  33. 33.
    XIA J, XU BO, XIE G J, et al. Therapeutic effects of mind-tranquilizing Chinese medicines on sleep-disorders by regulating energy metabolism:A review [J]. Chin J Exp Tradit Med Form, 222,28(7):40-48.

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