References
- 1.WANG H,LIU D,ZHENG B,et al.Emerging role of ferroptosis in diabetic kidney disease:Molecular mechanisms and therapeutic opportunities[J].Int J Biol Sci,2023,19(9):2678-2694.
- 2.SAEEDI P,PETERSOHN I,SALPEA P,et al. Global and regional diabetes prevalence estimates for 2019 and projections for 2030 and 2045: Results from the International Diabetes Federation Diabetes Atlas, 9(th) edition[J].Diabetes Res Clin Pract,2019,157:107843.
- 3.TANG A,ZHANG Y,WU L,et al. Klotho's impact on diabetic nephropathy and its emerging connection to diabetic retinopathy[J].Front Endocrinol(Lausanne),2023,14:1180169.
- 4.INADA A,INADA O,YASUNAMI Y,et al. Amelioration of murine diabetic nephropathy with a SGLT2 inhibitor is associated with suppressing abnormal expression of hypoxia-inducible factors[J].Am J Pathol,2022,192(7):1028-1052.
- 5.NIU G,ZHOU M,WANG F,et al. Marein ameliorates Ang Ⅱ/hypoxia-induced abnormal glucolipid metabolism by modulating the HIF-1α/PPARα/γ pathway in H9c2 cells[J].Drug Dev Res,2021,82(4):523-532.
- 6.WANG S,QIN S,CAI B,et al.Promising therapeutic mechanism for Chinese herbal medicine in ameliorating renal fibrosis in diabetic nephropathy[J].Front Endocrinol(Lausanne),2023,14:932649.
- 7.RUAN Y,LING J,YE F,et al. Paeoniflorin alleviates CFA-induced inflammatory pain by inhibiting TRPV1 and succinate/SUCNR1-HIF-1α/NLPR3 pathway[J].Int Immunopharmacol,2021,101(Pt B):108364.
- 8.CHANG J,ZHENG J,GAO X,et al.Tangshen Weining formula prevents diabetic nephropathy by protecting podocytes through the SIRT1/HIF-1α pathway[J].Front Endocrinol(Lausanne),2022,13:888611.
- 9.SEMENZA G L,WANG G L.A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation[J].Mol Cell Biol,1992,12(12):5447-5454.
- 10.LIAO Q,DENG H,WANG Z,et al.Deletion of prolyl hydroxylase domain-containing enzyme 3(PHD3) in zebrafish facilitates hypoxia tolerance[J].J Biol Chem,2023,299(12):105420.
- 11.ZHANG Y,YANG Y,HU X,et al.RAS protein activator-like 2 (RASAL2) initiates peritubular capillary rarefaction in hypoxic renal interstitial fibrosis[J].Transl Res,2024,269:14-30.
- 12.WANG D,WANG F,HUANG Y,et al.TSLP/TSLPR promotes renal fibrosis by activating STAT3 in renal fibroblasts[J].Int Immunopharmacol,2023,121:110430.
- 13.TANG M,LI Q Y,LI S B,et al.Effects of L-mimosine on renal hypoxia and HIF/PHD axis in diabetic rats[J].J Zunyi Med Univ,2019,42(5):527-533.
- 14.GUAN Z,JIN X,GUAN Z,et al.The gut microbiota metabolite capsiate regulate SLC2A1 expression by targeting HIF-1α to inhibit knee osteoarthritis-induced ferroptosis[J].Aging Cell,2023,22(6):e13807.
- 15.IACOBINI C,VITALE M,HAXHI J,et al.Mutual regulation between redox and hypoxia-inducible factors in cardiovascular and renal complications of diabetes[J].Antioxidants(Basel),2022,11(11):2183.
- 16.JATHO A,ZIESENISS A,BRECHTEL-CURTH K,et al.The HIFα-stabilizing drug roxadustat increases the number of renal epo-producing Sca-1+ cells[J].Cells,2022,11(4):753.
- 17.WU M,CHEN W,MIAO M,et al.Anti-anemia drug FG4592 retards the AKI-to-CKD transition by improving vascular regeneration and antioxidative capability[J].Clin Sci(Lond),2021,135(14):1707-1726.
- 18.ZHENG X,LIU D.Adiponectin alleviates the symptoms of ischemic renal disease by inhibiting renal cell apoptosis[J].Life Sci,2021,265:118825.
- 19.SAMAAN E,RAMADAN N M,ABDULAZIZ H,et al.DPP-4i versus SGLT2i as modulators of PHD3/HIF-2α pathway in the diabetic kidney[J].Biomed Pharmacother,2023,167:115629.
- 20.PACKER M.Mechanisms leading to differential hypoxia-inducible factor signaling in the diabetic kidney modulation by SGLT2 inhibitors and hypoxia mimetics[J].Am J Kidney Dis,2021,77(2):280-286.
- 21.HE J Y,HONG Q,CHEN B X,et al Ginsenoside Rb1 alleviates diabetic kidney podocyte injury by inhibiting aldose reductase activity[J].Acta Pharmacol Sin,2022,43(2):342-353.
- 22.SUN H,LI X,CHEN X,et al. Drp1 activates ROS/HIF-1α/EZH2 and triggers mitochondrial fragmentation to deteriorate hypercalcemia-associated neuronal injury in mouse model of chronic kidney disease[J].J Neuroinflammation,2022,19(1):213.
- 23.LIANG S,NAYAK B K,VOGEL K S,et al.TP63 Is significantly upregulated in diabetic kidney[J].Int J Mol Sci,2021,22(8):4070.
- 24.JIANG Y,XIE F,LV X,et al.Mefunidone ameliorates diabetic kidney disease in STZ and db/db mice[J].FASEB J,2021,35(1):e21198.
- 25.JAHAN H,SIDDIQUI N N,IQBAL S,et al. Indole-linked 1,2,3-triazole derivatives efficiently modulate COX-2 protein and PGE2 levels in human THP-1 monocytes by suppressing AGE-ROS-NF-κB nexus[J].Life Sci,2022,291:120282.
- 26.WANG X,YAO B,WANG Y,et al.Macrophage cyclooxygenase-2 protects against development of diabetic nephropathy[J].Diabetes,2017,66(2):494-504.
- 27.FENG X,WANG S,SUN Z,et al.Ferroptosis enhanced diabetic renal tubular injury via HIF-1α/HO-1 pathway in db/db mice[J].Front Endocrinol(Lausanne),2021,12:626390.
- 28.DEFRONZO R A,REEVES W B,AWAD A S. Pathophysiology of diabetic kidney disease:Impact of SGLT2 inhibitors[J].Nat Rev Nephrol,2021,17(5):319-334.
- 29.LÖWEN J,GRÖNE E,GRÖNE H J,et al.Herniation of the tuft with outgrowth of vessels through the glomerular entrance in diabetic nephropathy damages the juxtaglomerular apparatus[J].Am J Physiol Renal Physiol,2019,317(2):F399-F410.
- 30.CHEN M,ZHONG K,TAN J,et al.Baicalein is a novel TLR4-targeting therapeutics agent that inhibits TLR4/HIF-1α/VEGF signaling pathway in colorectal cancer[J].Clin Transl Med,2021,11(11):e564.
- 31.SUN W X,GAO Y Y,CAO Y,et al.Catalpol prevents glomerular angiogenesis induced by advanced glycation end products via inhibiting galectin-3[J].Curr Med Sci,2023,43(4):668-678.
- 32.XU Y,KONG X,LI J,et al.Mild hypoxia enhances the expression of HIF and VEGF and triggers the response to injury in rat kidneys[J].Front Physiol,2021,12:690496.
- 33.IKEDA M,IDE T,TADOKORO T,et al.Excessive hypoxia-inducible factor-1α expression induces cardiac rupture via p53-dependent apoptosis after myocardial infarction[J].J Am Heart Assoc,2021,10(17):e020895.
- 34.YFANTIS A,MYLONIS I,SIMOS G.Direct interaction between mortalin and HIF-1α at the mitochondria inhibits apoptosis by blocking recruitment of Bax[J].FEBS J,2023,290(15):3764-3780.
- 35.FU M,PENG D,LAN T,et al. Multifunctional regulatory protein connective tissue growth factor(CTGF):A potential therapeutic target for diverse diseases[J].Acta Pharm Sin B,2022,12(4):1740-1760.
- 36.QIAN L,REN S,XU Z,et al. Qianyang Yuyin granule improves renal injury of hypertension by regulating metabolic reprogramming mediated by HIF-1α/PKM2 positive feedback loop[J].Front Pharmacol,2021,12:667433.
- 37.ARELLANO-BUENDÍA A S,CASTAÑEDA-LARA L G,LOREDO-MENDOZA M L,et al.Effects of allicin on pathophysiological mechanisms during the progression of nephropathy associated to diabetes[J].Antioxidants(Basel),2020,9(11):1134.
- 38.LIU L,ZHANG P,BAI M,et al. p53 upregulated by HIF-1α promotes hypoxia-induced G2/M arrest and renal fibrosis in vitro and in vivo[J].J Mol Cell Biol,2019,11(5):371-382.
- 39.ZHAO H,HAN Y,JIANG N,et al.Effects of HIF-1α on renal fibrosis in cisplatin-induced chronic kidney disease[J].Clin Sci(Lond),2021,135(10):1273-1288.
- 40.SUN S,NING X,ZHANG Y,et al.Hypoxia-inducible factor-1alpha induces Twist expression in tubular epithelial cells subjected to hypoxia, leading to epithelial-to-mesenchymal transition[J].Kidney Int,2009,75(12):1278-1287.
- 41.HE Y P,JIA D K,CHEN W Y,et al.Research progress on traditional Chinese medicine intervention in diabetic nephropathy based on mitophagy[J].Inf Tradit Chin Med,2024,41(11):72-78.
- 42.CUI K,LIU J,HUANG L,et al.Andrographolide attenuates choroidal neovascularization by inhibiting the HIF-1α/VEGF signaling pathway[J].Biochem Biophys Res Commun,2020,530(1):60-66.
- 43.LV B,ZHENG K,SUN Y,et al.Network pharmacology experiments show that emodin can exert a protective effect on MCAO rats by regulating Hif-1α/VEGF-A signaling[J].ACS Omega,2022,7(26):22577-22593.
- 44.XU W L,LIU S,LI N,et al.Quercetin antagonizes glucose fluctuation induced renal injury by inhibiting aerobic glycolysis via HIF-1α/miR-210/ISCU/FeS pathway[J].Front Med(Lausanne),2021,8:656086.
- 45.CHEN S L,KANG Z F,CHU W L,et al.Mechanism study of curcumin on inhibiting experimental choroidal neovascularization in vitro by Akt/HIF-1α/VEGF pathway [J].Int Eye Sci, 2022,22(4):541-548.
- 46.HOU J.Effect of Huangkui capsule and tretinoin polyglucoside combined with valsartan in the treatment of patients with stage Ⅳ diabetic nephropathy[J].Henan Med Res,2020,29(22):4145-4147.
- 47.DONG X G,AN Z M,GUO Y,et al. Effect of triptolide on expression of oxidative carbonyl protein in renal cortex of rats with diabetic nephropathy[J].J Huazhong Univ Sci Technol Med Sci,2017,37(1):25-29.
- 48.YU X H,HE Y L,YANG Y F,et al.Tripterygium Glycosides tablets affect the levels of heat shock protein 90 and PGC-1α in rats with diabetic nephropathy through PI3K/Akt pathway[J].China J Mod Med,2021,31(22):10-16.
- 49.LI M X,QIAO H X,WANG X L,et al.Effects of tripterygium glycosides on high glucose induced apoptosis of human renal tubular epithelial cells and CXCL10/CXCR3 axis [J].Tianjin Med J,2023,51(2):139-143.
- 50.JIANG S,FAN F,YANG L,et al.Salidroside attenuates high altitude hypobaric hypoxia-induced brain injury in mice via inhibiting NF-κB/NLRP3 pathway[J].Eur J Pharmacol,2022,925:175015.
- 51.PEI D,TIAN S,BAO Y,et al.Protective effect of salidroside on streptozotocin-induced diabetic nephropathy by inhibiting oxidative stress and inflammation in rats via the Akt/GSK-3β signalling pathway[J].Pharm Biol,2022,60(1):1732-1738.
- 52.XIE R Y,FANG X L,HAMZE I,et al.Salidroside attenuates high glucose-induced rat renal glomerular endothelial cell injury via up-regulating HIF-1α expression[J].Chin J Pathophysiol,2019,35(2):237-242.
- 53.WANG S,ZHAO X,YANG S,et al. Salidroside alleviates high glucose-induced oxidative stress and extracellular matrix accumulation in rat glomerular mesangial cells by the TXNIP-NLRP3 inflammasome pathway[J].Chem Biol Interact,2017,278:48-53.
- 54.SHAN J P,GUAN J C,DONG Z C,et al.Cordyceps sinensis ameliorates cisplatin-induced nephrotoxicity in mice through inhibition of oxidative stress,inflammation,and apoptosis[J].Chin J Integr Tradit West Nephrol,2019,20(6):474-477,565.
- 55.ZHANG L Y,JIN J,JIN J Z,et al.Cordyceps sinensis protects against tacrolimus-induced pancreatic and pe-nal injury[J].Chin J Gerontol,2019,39(2):361-367.
- 56.YUAN M X,TANG R,ZHOU Q L,et al.Effect of Cordyceps sinensis on expressions of HIF-1α and VEGF in the kidney of rats with diabetic nephropathy[J].J Central South Univ: Med Sci,2013,38(5):448-457.
- 57.KU C W,HO T J,HUANG C Y,et al.Cordycepin attenuates palmitic acid-Induced inflammation and apoptosis of vascular endothelial cells through mediating PI3K/Akt/eNOS signaling pathway[J].Am J Chin Med,2021,49(7):1703-1722.
- 58.SHAO Y,LV C,WU C,et al.Mir-217 promotes inflammation and fibrosis in high glucose cultured rat glomerular mesangial cells via Sirt1/HIF-1α signaling pathway[J].Diabetes Metab Res Rev,2016,32(6):534-543.
- 59.DU L,WANG L,WANG B,et al.A novel compound AB38b attenuates oxidative stress and ECM protein accumulation in kidneys of diabetic mice through modulation of Keap1/Nrf2 signaling[J].Acta Pharmacol Sin,2020,41(3):358-372.
- 60.SONG W,LIU G Y,TIAN H,et al.Effects of piceatannol on renal fibrosis and HO-1 and HIF-1 a expressions in diabetic nephropathy rats[J].Acta Nutr Sin,2021,43(1):86-91.
- 61.CHEN W,TIAN L,LI Y,et al.Effects of momordica total saponins to HIF-1α and VEGF expression in kidney tissue of type 2 diabetic nephropathy rats[J].Global Tradit Chin Med,2016,9(6):659-663.
- 62.CHEN J,OU Z,GAO T,et al.Ginkgolide B alleviates oxidative stress and ferroptosis by inhibiting GPX4 ubiquitination to improve diabetic nephropathy[J].Biomed Pharmacother,2022,156:113953.
- 63.WILLSON J A,ARIENTI S,SADIKU P,et al.Neutrophil HIF-1α stabilization is augmented by mitochondrial ROS produced via the glycerol 3-phosphate shuttle[J].Blood,2022,139(2):281-286.
- 64.WANG Y,CAO Z,WEI Q,et al. VH298-loaded extracellular vesicles released from gelatin methacryloyl hydrogel facilitate diabetic wound healing by HIF-1α-mediated enhancement of angiogenesis[J].Acta Biomater,2022,147:342-355.
- 65.FU Z J,WANG Z Y,XU L,et al. HIF-1α-BNIP3-mediated mitophagy in tubular cells protects against renal ischemia/reperfusion injury[J].Redox Biol,2020,36:101671.
- 66.XU B,ZHENG J,TIAN X,et al. Protective mechanism of traditional Chinese medicine Guizhi Fuling pills against carbon tetrachloride-induced kidney damage is through inhibiting oxidative stress, inflammation and regulating the intestinal flora[J].Phytomedicine,2022,101:154129.
- 67.YANG Y Q,TAN H B,ZHANG X Y,et al.The Chinese medicine Fufang Zhenzhu Tiaozhi capsule protects against renal injury and inflammation in mice with diabetic kidney disease[J].J Ethnopharmacol,2022,292:115165.


