HIF-1α механизм исследования диабетической нефропатии и прогресса традиционной китайской медицины

  • role: First author第一作者
  • Affiliation:

    School of Traditional Chinese Medicine,Southern Medical University,Guangzhou 510515,China

    Zhujiang Hospital of Southern Medical University,Guangzhou 510280,China

  • Email:983912829@qq.com
  • Introduction:西E-mail983912829@qq.com
XIE Jiarun12,  
  • Affiliation:

    School of Traditional Chinese Medicine,Southern Medical University,Guangzhou 510515,China

    Zhujiang Hospital of Southern Medical University,Guangzhou 510280,China

LIN Haoyu12,  
  • Affiliation:

    School of Traditional Chinese Medicine,Southern Medical University,Guangzhou 510515,China

CHEN Xi1,  
  • Affiliation:

    Zhujiang Hospital of Southern Medical University,Guangzhou 510280,China

SUN Jia2,  
  • role: Corresponding author通信作者
  • Affiliation:

    School of Traditional Chinese Medicine,Southern Medical University,Guangzhou 510515,China

    Zhujiang Hospital of Southern Medical University,Guangzhou 510280,China

  • Email:wming1999@163.com
  • Introduction:西E-mailwming1999@163.com
WANG Ming12*

реферат

В последние годы диабетическая нефропатия (DN) стала все более острой глобальной проблемой в области здравоохранения, с резким увеличением заболеваемости и смертности, а также с увеличением возраста пациентов. DN не только сопровождается обширными патологическими изменениями почек, такими как почечное увеличение, инфильтрация воспалительных клеток, расширение мезанхимальной матрицы и утолщение базальной мембраны, но и является основной причиной развития поздней стадии почечной недостаточности и смерти у пациентов с диабетом, поэтому исследование новых стратегий профилактики и лечения DN становится особенно актуальным. Механизм развития DN сложен и многофакторен, исследования в основном сосредотачиваются на взаимодействии метаболических и гемодинамических факторов, таких как гипоксия, воспалительная реакция и фиброзный процесс. Следует отметить, что гипоксия играет определяющую роль в инициации и прогрессировании DN. Фактор индуцированной гипоксией -1 α (HIF-1 α), как ключевой регулирующий белок, широко распространенный в клетках с гипоксией, оказывает глубокое влияние на клеточный метаболизм, ангиогенез, реакцию окислительного стресса и апоптоз и другие физиологические и патологические процессы. И традиционная китайская медицина, благодаря уникальной теоретической системе и методам лечения, проявила значительное преимущество в борьбе с гипоксическими заболеваниями, способна регулировать уровни экспрессии HIF-1 α и его сигнальных молекул, оказывать противовоспалительное, антиоксидантное и противофиброзное действие, замедляя прогрессирование DN, что имеет положительное клиническое значение для разработки лекарств и ранней профилактики DN.

ключеви́че слова́

диабетическая нефропатия; гипоксия; фактор индуцированной гипоксией-1 α; метаболическая регуляция; традиционная китайская медицина

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