Бессонница и старение кожи: теоретическое исследование 'одной болезни, одного механизма, одной болезни, лечения, профилактики'

  • role: First author第一作者
  • Affiliation:

    National Administration of Traditional Chinese Medicine(TCM)High Level Key Construction Discipline Neijing Studies of TCM,Hubei University of Chinese Medicine,Wuhan 430065,China

    Hubei Shizhen Laboratory, Wuhan 430065, China

  • Email:3211@hbucm.edu.cn
  • Introduction:E-mail3211@hbucm.edu.cn
XU Bo12,  
  • Affiliation:

    National Administration of Traditional Chinese Medicine(TCM)High Level Key Construction Discipline Neijing Studies of TCM,Hubei University of Chinese Medicine,Wuhan 430065,China

    Hubei Shizhen Laboratory, Wuhan 430065, China

ZHU Miao12,  
  • Affiliation:

    National Administration of Traditional Chinese Medicine(TCM)High Level Key Construction Discipline Neijing Studies of TCM,Hubei University of Chinese Medicine,Wuhan 430065,China

    Hubei Shizhen Laboratory, Wuhan 430065, China

SUN Kang12,  
  • role: Corresponding author通信作者
  • Affiliation:

    National Administration of Traditional Chinese Medicine(TCM)High Level Key Construction Discipline Neijing Studies of TCM,Hubei University of Chinese Medicine,Wuhan 430065,China

    Hubei Shizhen Laboratory, Wuhan 430065, China

  • Email:happypyy05@126.com
  • Introduction:E-mailhappypyy05@126.com
PENG Yuan12*,  
  • Affiliation:

    National Administration of Traditional Chinese Medicine(TCM)High Level Key Construction Discipline Neijing Studies of TCM,Hubei University of Chinese Medicine,Wuhan 430065,China

    Hubei Shizhen Laboratory, Wuhan 430065, China

WANG Ping12,  
  • Affiliation:

    National Administration of Traditional Chinese Medicine(TCM)High Level Key Construction Discipline Neijing Studies of TCM,Hubei University of Chinese Medicine,Wuhan 430065,China

    Hubei Shizhen Laboratory, Wuhan 430065, China

YANG Li12

реферат

Сон, кожа и здоровье тесно связаны, в клинической практике распространенность бессонницы высока и часто сопровождается или сопутствует старению кожи, оба они 'разные болезни с одинаковыми симптомами', что серьезно влияет на физическое и психическое здоровье населения, с точки зрения лечения, улучшение бессонницы и профилактика старения кожи является важной стратегией лечения, 'одно заболевание, одно лечение' - это его важный принцип лечения; но в настоящее время в клинической практике отсутствуют эффективные методы профилактики и лечения обоих заболеваний, традиционная китайская медицина очень эффективна и богата в профилактике и лечении бессонницы и старения кожи, но мало известно о причинах, механизмах болезни, принципах и методах лечения обоих заболеваний, чего требует глубокое изучение. Представленная статья основана на китайской традиционной концепции, диагностике и принципах лечения с позиций причины, точки поражения, механизмов болезни, природы болезни, профилактики и т. д., и мы обнаружили, что еще в период Книги внутреннего Канона' было признано, что днем ясность, ночью темнота, кожа плотная - это важный внешний показатель здоровья, днем нет ясности, ночью нет темноты, кожа обветривается и стареет, является важным признаком старения; в последние времена врачи считают, что общие причины бессонницы и старения кожи - 'взаимное действие внутри и снаружи', точка поражения - 'пять основных органов', механизма болезни - 'дефицит огня, задержка грязи, скопление флегмы и крови', природа болезни - 'смешанная недостаточность', лечение и профилактика - 'диагностика и лечение, метод на основе инь-иань'. Это теоретическое изучение дополнительно будет обогащать и развивать теорию китайской медицины в возникновении и профилактике и даст только теоретическое руководство по лечению бессонницы сопровождаемой старением кожи в клинической области, и содействует построению 'здоровой Китайской'.

ключеви́че слова́

Бессонница; старение кожи; общее лечение; 'причина-механизм-свидетельство-лечение-профилактик'; теоретическое исследование

References

  1. 1.
    BOCHEVA G,SLOMINSKI R M,JANJETOVIC Z,et al. Protective role of melatonin and its metabolites in skin aging[J].Int J Mol Sci,2022,23 (3):1238.
  2. 2.
    Chinese Sleep Research Society. White paper on the sleep health of Chinese residents in 2024[M].Beijing:Chinese Sleep Research Society, 2024.
  3. 3.
    LÉGER D,GAURIAU C,ETZI C,et al. "You look sleepy…" The impact of sleep restriction on skin parameters and facial appearance of 24 women[J].Sleep Med,2022,89:97-103.
  4. 4.
    HUANG P P. Exploring the sleep theory in Neijing from point of "heart is incharge of spirit" and the intervention mechanism of Tianwang Buxin pills on senile insomnia rats model[D].Wuhan: Hubei University of Chinese Medicine, 2010.
  5. 5.
    SHEN Q, TAN X, WANG W Z. Autonomic nervous dysfunction caused by circadian disruption:Research progress[J]. Acad J Nav Med Univ, 2024,45(3):328-332.
  6. 6.
    WANG P. Analysis on the health standard of Huangdi Neijing[J].China J Tradit Chin Med Pharm, 2021,36(1):17-21.
  7. 7.
    FENG M,ZHENG X,WAN J,et al. Research progress on the potential delaying skin aging effect and mechanism of tea for oral and external use[J].Food Funct,2021,12 (7):2814-2828.
  8. 8.
    LE FUR I,REINBERG A,LOPEZ S,et al. Analysis of circadian and ultradian rhythms of skin surface properties of face and forearm of healthy women[J].J Invest Dermatol,2001,117 (3):718-724.
  9. 9.
    ZHAI S,TAO S,WU X,et al. Associations of sleep insufficiency and chronotype with inflammatory cytokines in college students[J].Nat Sci Sleep,2021,13:1675-1685.
  10. 10.
    LIANG L Y, LU R, ZHANG Y, et al. Anti-skin aging effects of aerobic and resistance exercise via IL-18/IL-18R pathway in SAMP8 mice[J].Chin J Pathophysiol, 2024,40(4):713-721.
  11. 11.
    JING Y, HU W S, HUI Q Q, et al. Discussion on the correlation between autophagy, alternative autophagy and skin aging based on the Ying-wei theory[J]. J Tradit Chin Med, 2022,63(18):1706-1711.
  12. 12.
    KRUTMANN J,BOULOC A,SORE G,et al. The skin aging exposome[J].J Dermatol Sci,2017,85 (3):152-161.
  13. 13.
    DU H R, MU J L, ZHAO H Z, et al. Relationship between sleep structure changes and sympathetic skin response in patients with insomnia[J]. Chin J Nerv Ment Dis, 2011,37(8):458-463.
  14. 14.
    HE B, CHEN Y, YU S, et al. Food plant extracts for sleep-related skin health:Mechanisms and prospects[J]. Food Biosci, 2022, 49:101951.
  15. 15.
    OYETAKIN-WHITE P,SUGGS A,KOO B,et al. Does poor sleep quality affect skin ageing?[J].Clin Exp Dermatol,2015,40 (1):17-22.
  16. 16.
    LI N H, ZHANG X B, LI Q J, et al. Research progress of circadian rhythm in skin aging[J]. Chin J Dermatol, 2022,36(3):343-346,358.
  17. 17.
    JANG S I,LEE M,HAN J,et al. A study of skin characteristics with long-term sleep restriction in Korean women in their 40s[J].Skin Res Technol,2020,26 (2):193-199.
  18. 18.
    ZHAO L. Research on the influencing factors of facial skin aging and the characteristics of traditional Chinese medicine deficiency syndromes in young women[D]. Beijing:Beijing University of Chinese Medicine, 2022.
  19. 19.
    YOON K,SHIN C M,HAN K,et al. Risk of cancer in patients with insomnia:Nationwide retrospective cohort study (2009-2018)[J].PLoS One,2023,18 (4):e0284494.
  20. 20.
    CHANG J,GARVA R,PICKARD A,et al. Circadian control of the secretory pathway maintains collagen homeostasis[J].Nat Cell Biol,2020,22 (1):74-86.
  21. 21.
    YU Y,ZHANG X,LIU F,et al. A stress-induced miR-31-CLOCK-ERK pathway is a key driver and therapeutic target for skin aging[J].Nat Aging,2021,1 (9):795-809.
  22. 22.
    FRANCO A C,AVELEIRA C,CAVADAS C.Skin senescence:Mechanisms and impact on whole-body aging[J].Trends Mol Med,2022,28 (2):97-109.
  23. 23.
    ZHANG S,DUAN E.Fighting against skin aging:The way from bench to bedside[J].Cell Transplant,2018,27 (5):729-738.
  24. 24.
    ZHANG C,GAO X,LI M,et al. The role of mitochondrial quality surveillance in skin aging:Focus on mitochondrial dynamics, biogenesis and mitophagy[J].Ageing Res Rev,2023,87:101917.
  25. 25.
    LIU S Y, MENG X J, ZHANG X K, et al. Mechanism of skin photoaging and anti-photoaging reagents[J]. Prog Physiol Sci,2018,49(4):265-269.
  26. 26.
    MEYER N,HARVEY A G,LOCKLEY S W,et al. Circadian rhythms and disorders of the timing of sleep[J].Lancet,2022,400 (10357):1061-1078.
  27. 27.
    LI Y J, ZHANG X P, CHEN J Y, et al. Discussion on insomnia caused by dysfunction of heart storing spirit[J]. China J Tradit Chin Med Pharm, 2017,32(3):947-949.
  28. 28.
    FAN X B, YAN Z P, GENG X F, et al. Exploration of clinical thoughts for treatment of stable angina with insomnia under the guidance of the "blood-pulse-heart-spirit"[J].J Tradit Chin Med, 2024,65(12):1240-1244.
  29. 29.
    LIU Y H, ZHAO C C, WANG G J. Anti-inflammatory effect of Xuefu Zhuyu tang in the treatment of chronic obstructive pulmonary disease and its influence on the TLR4/MyD88/NF-κB signaling pathway[J].Chin J Mod Appl Pharm, 2024,41(15):2090-2094.
  30. 30.
    ZOU Y M, ZOU C P, CHEN X, et al. Reflections on the connection between traditional Chinese medicine and western medicine based on the theory of "lung governing skin and hair"[J]. J Beijing Univ Tradit Chin Med, 2024,47(1):42-48.
  31. 31.
    KOULAOUZIDIS A,BHAT S,MOSCHOS J. Skin manifestations of liver diseases[J].Ann Hepatol,2007,6 (3):181-184.
  32. 32.
    CAO C,XIAO Z,WU Y,et al. Diet and skin aging-from the perspective of food nutrition[J].Nutrients,2020,12 (3):870.
  33. 33.
    ZHANG P, LI T, WU Y G, et al. Preparation of rat model of perimenopausal skin barrier dysfunction of "Yin deficiency of liver and kidney"[J]. Liaoning J Tradit Chin Med, 2024,51(12):5-9,237.
  34. 34.
    HIRAMOTO K, GOTO K, TANAKA S, et al. Skin, liver, and kidney interactions contribute to skin dryness in aging KK-Ay/tajcl mice[J].Biomedicines, 2022,10(10):2648-2662.
  35. 35.
    WANG L, LI F, YU XW, et al. Investigation and analysis of characteristics of menopause-related symptoms and menopausal hormone therapy cognition status[J].J Xian Jiaotong Univ:Med Sci, 2024,45(4):629-636.
  36. 36.
    LU P J. Analysis of contemporary documents on the medication rule of traditional Chinese medicine in treating aging skin[D].Guangzhou:Guangzhou Univ Chin Medicine, 2018.
  37. 37.
    DANG J J,YU Y,LEI H T,et al.Syndrome research on chronic insomnia[J].Chin J Basic Med Tradit Chin Med, 2022,28(9):1547-1550.
  38. 38.
    WANG X M, ZHANG Y H, ZHANG L T. The gut-brain-skin axis and atopic dermatitis [J]. Chin J Dermatovenereol Integr Tradit West Med, 2018,17(1):83-86.
  39. 39.
    LUO Y, LIU Z, YAO D N, et al. Highlights of TCM master XUAN Guo-wei's experience in identifying and treating dermatosis with balanced thinking[J].China J Tradit Chin Med Pharm, 2022,37(7):3889-3892.
  40. 40.
    MA C, CHAI K F. Study on the clinical application and theory of Huanglian Ejiao decoction[J]. China J Tradit Chin Med Pharm, 2015,30(4):996-999.
  41. 41.
    WANG L Y, DUAN Y Q, LI N L, et al. Four Gentlemen decoction and its modified prescriptions in treating insomnia based on the theory of "stomach disharmony inducing restlessness"[J].Tradit Chin Med Res, 2018,31(9):36-39.
  42. 42.
    JIANG K J. An empirical study on skin influence of D-galactose SD rat subacute aging model through decoction of four mild drugs[D]. Dalian:Dalian Med Univ, 2008.
  43. 43.
    YAO L M,LI W R,SUN L C.Experimental study on the anti-aging effects of Xiaoyaosan and Chaihu Shugansan in liver depression[J].Chin J Exp Tradit Med Form, 2006,12(5):65-66.
  44. 44.
    XIN P.Efficacy observation of Chaihu Shugan powder sombined with Shixiao powder in treating melasma of liver depression and Qi stagnation type[J].J Lishizhen Tradit Chin Med, 2021,32(2):369-371.
  45. 45.
    NING Y T, CHENG J Y, WANG T T. Effect and mechanism of Xuefu Zhuyutang on unpredictable stimulus-induced blood stasis[J].Chin J Exp Tradit Med Form, 2016,22(4):110-114.
  46. 46.
    LIU Y,YANG Y,SU C,et al.Mechanism of Xuefu Zhuyutang in intervening in ferroptosis in rats with coronary heart disease with blood stasis syndrome based on ACSL4 signalling pathway[J].Chin J Exp Tradit Med Form,2025,31(6):27-38.
  47. 47.
    CHEN J P, PENG Y, HONG X M, et al. Mechanism of modified Tianwang Buxindan on skin of sleep-deprived mice through PI3K/Akt/Nrf2 signaling pathway[J]. Chin J Exp Tradit Med Form, 2024,30(11):120-128.
  48. 48.
    WANG F, YU Y, MAO S X, et al. Preliminary study on the treatment of insomnia by acupoint application therapy[J]. Chin J Basic Med Tradit Chin Med,2018,24(1):104-107.
  49. 49.
    ZHANG Q,QI X,WANG Z,et al. The association between dietary vitamin C and sleep disorders: A cohort study based on UK biobank[J].Nutrients,2024,16 (21):3661.
  50. 50.
    LEBLANC M,MÉRETTE C,SAVARD J,et al.Incidence and risk factors of insomnia in a population-based sample[J].Sleep,2009,32 (8):1027-1037.
  51. 51.
    ZHANG J L, YE Y X, WEI J H, et al. Anti-aging effect of dietary restriction on skin of female aged rats induced by D-galactose[J].Acta Nutr Sin, 2018,40(5):509-511.
  52. 52.
    DALGARD F J,GIELER U,TOMAS-ARAGONES L,et al. The psychological burden of skin iseases:A cross-sectional multicenter study among dermatological out-patients in 13 European countries[J].J Invest Dermatol, 2015,135(4):984-991.

Читать полностью

The above content is generated by Large Model Translation. The translated content is for reference only. We do not assume any commercial or legal responsibilty for any consequences arising from the use of our website