References
- 1.BIGBEE J W.Cells of the central nervous system:An overview of their structure and function[J].Adv Neurobiol,2023,29:41-64.
- 2.XUE J,MA W,XU S Y,et al.Research progress on treatment of central nervous system diseases with active ingredients of Paeoniae Radix Rubra[J].Chin Tradit Herb Drugs,2024,55(19):6806-6819.
- 3.WANG Q,KONG D Z,ZHANG W,et al.Research progress of Chinese medicine in treatment of central nervous system diseases through blood-brain barrier[J].Chin J Integr Tradit West Med,2024,44(8):1013-1018.
- 4.WANG L,WU L E,JIA J X,et al.Pharmacological effects of roucongrong(Cistanches Herba) and its research progress in central nervous system diseases[J].Chin J Tradit Chin Med,2024,42(3):50-54.
- 5.ZHANG Y X.Interpretation of "Shennong's Classic of Materia Medica"(50)[J].Kai Juan You Yi - Qiu Yi Wen Yao,2017,37(2):50-51.
- 6.LI S Z.Bencao Gangmu[M].Beijing:People's Medical Publishing House,2023:880.
- 7.LUO Q,JIN H Y,YANG J B,et al.Research progress on the therapeutic effects,clinical applications and modern pharmacological actions of Lycium barbarum L.Berries[J].Drug Evaluation Res,2024,47(10):2427-2433.
- 8.ZHOU Z Q.Research on the active components of Lycium barbarum against Alzheimer's disease[D].Gangzhou:Jinan University,2016.
- 9.ZHANG Y H,SHEN Y.Potential mechanism of Lycii Fructus in the treatment of stroke based on network pharmacology[J].Strait Pharm J,2023,35(12):12-17.
- 10.SONG H J,ZHANG Q L,CUI Z J,et al.Research progress on chemical constituents and pharmacological effects of Lycii Fructus and its quality marker prediction and analysis[J].West China J Pharm Sci,2022,37(2):206-213.
- 11.TIAN X J,LIANG T S,LIU Y L,et al.Extraction,structural characterization,and biological functions of Lycium barbarum polysaccharides:A review[J].Biomolecules,2019,doi:.
- 12.CHEN L,DUAN A Y,LI Y J,et al.Research progress on biological activity and application of Lycium barbarum polysaccharide[J]. Sci Technol Food Ind,2025,doi: .
- 13.WANG S L,ZAI Q Y,CHEN H G,et al.Comparison on biological activities of Lycium barbarum polysaccharides extracted with five methods[J].China J Chin Mater Med,2024,49(1):110-122.
- 14.LIU X.Based on the Nrf2/HO-1 signaling pathway probe the protective effect and mechanism of Lycium barbarum glycopeptide on retinal injury in rats with acute ocular hypertension[D].Chengdu:Chengdu Univ Tradit Chin Med,2022.
- 15.YANG T T,HU Y H,YAN Y M,et al.Characterization and evaluation of antioxidant and anti-inflammatory activities of flavonoids from the fruits of Lycium barbarum[J].Foods,2022,11(3):306.
- 16.SONG W N,ZHANG S X,LU F,et al.Active components of Salviae Miltiorrhizae Radix et Rhizoma and its compound in treatment of nervous system diseases:A review[J].Chin J Exp Tradit Med Form,2025,31(2):303-313.
- 17.WU J X,CHEN T,WAN F Q,et al.Structural characterization of a polysaccharide from Lycium barbarum and its neuroprotective effect against β-amyloid peptide neurotoxicity[J].Int J Biol Macromol,2021,176:352-363.
- 18.ZHOU Y,DUAN Y H,HUANG S C,et al.Polysaccharides from Lycium barbarum ameliorate amyloid pathology and cognitive functions in APP/PS1 transgenic mice[J].Int J Biol Macromol,2020,144:1004-1012.
- 19.HE Y X,WANG Y Y,LI X,et al.Lycium barbarum polysaccharides improves cognitive functions in ICV-STZ-induced Alzheimer's disease mice model by improving the Synaptic structural plasticity and regulating IRS1/PI3K/Akt signaling pathway[J].Neuro Molecular Med,2024,26(1):15.
- 20.LIU X R.Effects of Lycium barbarum polysaccharides on Aβ42-induced oxidative damage in SH-SY5Y cells and lipopolysaccharide induced inflammatory in BV2 cells[D].Yinchuan:Ningxia University,2018.
- 21.WANG X H,PANG L,ZHANG Y Q,et al.Lycium barbarum polysaccharide promotes nigrostriatal dopamine function by modulating PTEN/Akt/mTOR pathway in a methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) murine model of Parkinson's disease[J].Neurochem Res,2018,43(4):938-947.
- 22.GAO K,LIU M Y,CAO J Y,et al.Protective effects of Lycium barbarum polysaccharide on 6-OHDA-induced apoptosis in PC12 cells through the ROS-NO pathway[J].Molecules,2014,20(1):293-308.
- 23.CHEN H,ZHANG H J,SHI L,et al.Antioxidative and neuroprotective effects of Lycium barbarum polysaccharide on Parkinson's disease mice[J].Chin J Nerv Ment Dis,2018,44(10):613-618.
- 24.SONG J B,LIU L,LI Z Q,et al.Lycium barbarum polysaccharide improves dopamine metabolism and symptoms in an MPTP-induced model of Parkinson's disease[J].BMC Med,2022,20(1):412.
- 25.ZHENG J M,LUO Z H,CHIU K,et al.Lycium barbarum glycopetide prolong lifespan and alleviate Parkinson's disease in Caenorhabditis elegans[J].Front Aging Neurosci,2023,15:1156265.doi:.
- 26.MA L,ZUO D,ZHANG C,et al.Protective effects of Lycium barbarum polysaccharides on epilepsy in rat hippocampal cell model and its mechanism[J].Chin New Drugs J,2020,29(23):2738-2743.
- 27.LI M J.Lycium barbarum polysaccharide exerts antidepressant effect by regulating gut microbiota[D].Chengdu:Chengdu Univ Tradit Chin Med,2013.
- 28.ZHANG E D,YAU S Y,LAU B W M,et al.Synaptic plasticity,but not hippocampal neurogenesis,mediated the counteractive effect of wolfberry on depression in rats(1)[J].Cell Transplant,2012,21(12):2635-2649.
- 29.DAI Y L,GUO J X,ZHANG B R,et al.Lycium barbarum(wolfberry) glycopeptide prevents stress-induced anxiety disorders by regulating oxidative stress and ferroptosis in the medial prefrontal cortex[J].Phytomedicine,2023,116:154864.
- 30.GE J P,LU H J,SONG X J,et al.Protective effects of LBP on cerebral ischemia reperfusion injury in mice and mechanism of inhibiting NF-κB,TNF-α,IL-6 and IL-1β[J].Chin J Chin Mater Med,2017,42(2):326-331.
- 31.ZHAO P,ZHOU R,ZHU X Y,et al.Neuroprotective effects of Lycium barbarum polysaccharide on focal cerebral ischemic injury in mice[J].Neurochem Res,2017,42(10):2798-2813.
- 32.LI X Y,PAN Y T,LI Y H,et al.Neuroprotective effect and its mechanism of Lycium barbarum polysaccharide on cerebral ischemia-reperfusion injury in mice[J].Chin J Clin Pharmacol,2017,33(20):2054-2057.
- 33.YU Y,WU X,PU J,et al.Lycium barbarum polysaccharide protects against oxygen glucose deprivation/reoxygenation-induced apoptosis and autophagic cell death via the PI3K/Akt/mTOR signaling pathway in primary cultured hippocampal neurons[J].Biochem Biophys Res Commun,2018,495(1):1187-1194.
- 34.LI P,YANG J,MA Y M,et al.Lycium barbarum glycopeptide attenuates cerebral ischemia/reperfusion injury in hyperglycemic rats through inhibition of ferroptosis[J].Chin Pharmacol Bull,2023,39(11):2043-2049.
- 35.QIU Z H,MA Y P,MA C S,et al.Lycium barbarum polysaccharide inhibits iron death through SLC7A11/GPX4 pathway to reduce cerebral ischemia-reperfusion injury in mice[J].Chin J Neuroanat,2024,40(5):607-612.
- 36.YE M,MOON J,YANG J,et al.The standardized Lycium chinense fruit extract protects against Alzheimer's disease in 3×Tg-AD mice[J].J Ethnopharmacol,2015,172:85-90.
- 37.HU X Y,QU Y D,CHU Q B,et al.Investigation of the neuroprotective effects of Lycium barbarum water extract in apoptotic cells and Alzheimer's disease mice[J].Mol Med Rep,2018,17(3):3599-3606.
- 38.MENG J,LV Z Y,GUO M M,et al.A Lycium barbarum extract inhibits β-amyloid toxicity by activating the antioxidant system and mtUPR in a Caenorhabditis elegans model of Alzheimer's disease[J].FASEB J,2022,36(2):e22156.
- 39.BAI X L,LUO Y J,FAN W Q,et al.Neuroprotective effects of Lycium barbarum fruit extract on Pink1(B9)drosophila melanogaster genetic model of Parkinson's disease[J].Plant Foods Hum Nutr,2023,78(1):68-75.
- 40.LIU J F,MENG J,DU J H,et al.Preparative separation of flavonoids from goji berries by mixed-mode macroporous adsorption resins and effect on a β-expressing and anti-aging genes[J].Molecules,2020,25(15):3511.
- 41.SCHELTENS P,DE STROOPER B,KIVIPELTO M,et al.Alzheimer's disease[J].Lancet,2021,397(10284):1577-1590.
- 42.ITOH S G, YAGI-UTSUMI M, KATO K, et al. Key residue for aggregation of amyloid-beta peptides[J]. ACS Chem Neurosci, 2022,13(22):3139-3151.
- 43.RAJESH Y,KANNEGANTI T D.Innate immune cell death in neuroinflammation and alzheimer's disease[J].Cells,2022,11(12):1885.
- 44.ISING C,VENEGAS C,ZHANG S S,et al.NLRP3 inflammasome activation drives tau pathology[J].Nature,2019,575(7784):669-673.
- 45.LAURETTI E, DINCER O, PRATICO D. Glycogen Synthase kinase-3 signaling in Alzheimer's disease[J]. Biochim Biophys Acta Mol Cell Res, 2020,1867(5):118664.
- 46.BAI R R,GUO J N,YE X Y,et al.Oxidative stress:The core pathogenesis and mechanism of Alzheimer's disease[J].Ageing Res Rev,2022,77:101619.
- 47.SHI L,YU X T,LI H,et al.D-chiro-inositol increases antioxidant capacity and longevity of caenorhabditis elegans via activating Nrf-2/SKN-1 and FoxO/DAF-16[J].Exp Gerontol,2023,175:112145.
- 48.ZHENG Q,LU Y,YU D H,et al.DIA proteomics reveals mechanism of acanthopanacis senticosi radix et rhizoma seu caulis extract in treating α-Syn transgenic Parkinson's disease in mice[J].Chin J Exp Tradit Med Form.2025,31(8):40-50.
- 49.LI Y N,XIA Y J,YIN S,et al.Targeting microglial α-Synuclein/TLRs/NF-κB/NLRP3 inflammasome axis in Parkinson's disease[J].Front Immunol,2021,12:719807.
- 50.IMBRIANI P,MARTELLA G,BONSI P,et al.Oxidative stress and Synaptic dysfunction in rodent models of Parkinson's disease[J].Neurobiol Dis,2022,173:105851.
- 51.LI W,FU Y H,HALLIDAY G M,et al.PARK genes link mitochondrial dysfunction and alpha-Synuclein pathology in sporadic parkinson's disease[J].Front Cell Dev Biol,2021,9:612476.
- 52.PALIKARAS K,LIONAKI E,TAVERNARAKIS N.Coordination of mitophagy and mitochondrial biogenesis during ageing in C.elegans[J].Nature,2015,521(7553):525-528.
- 53.TERRONE G,BALOSSO S,PAULETTI A,et al.Inflammation and reactive oxygen species as disease modifiers in epilepsy[J].Neuropharmacology,2020,167:107742.
- 54.DING Y Q,YUAN H M,CHEN X,et al.Progress in modern medical treatment of depression[J].West Med,2024,36(4):614-618.
- 55.MARTIN C R,OSADCHIY V,KALANI A,et al.The brain-gut-microbiome axis[J].Cell Mol Gastroenterol Hepatol,2018,6(2):133-148.
- 56.ZHANG P J,LI H H,ZHU L Q,et al.The influence on the behavior of chronic psychological stress in rats by sports exercise and Ningxia medlar[J].J North Sichuan Med Coll,2014,29(1):10-15.
- 57.LIANG X,TANG J,CHAO F L,et al.Exercise improves depressive symptoms by increasing the number of excitatory Synapses in the hippocampus of CUS-Induced depression model rats[J].Behav Brain Res,2019,374:112115.
- 58.CHANG J,YANG H M,SHAN X Q,et al.Bergamot essential oil improves CUMS-induced depression-like behaviour in rats by protecting the plasticity of hippocampal neurons[J].J Cell Mol Med,2024,28(8):e18178.
- 59.YU X D,ZHU Y,SUN Q X,et al.Distinct serotonergic pathways to the amygdala underlie separate behavioral features of anxiety[J].Nat Neurosci,2022,25(12):1651-1663.
- 60.DANG R Z,WANG M Y,LI X H,et al.Edaravone ameliorates depressive and anxiety-like behaviors via Sirt1/Nrf2/HO-1/Gpx4 pathway[J].J Neuroinflammation,2022,19(1):41.
- 61.JOLUGBO P,ARIENS R A S.Thrombus composition and efficacy of thrombolysis and thrombectomy in acute ischemic stroke[J].Stroke,2021,52(3):1131-1142.
- 62.XU D D,KONG T T,SHAO Z Q,et al.Orexin-a alleviates astrocytic apoptosis and inflammation via inhibiting OX1R-mediated NF-κB and MAPK signaling pathways in cerebral ischemia/reperfusion injury[J].Biochim Biophys Acta BBA Mol Basis Dis,2021,1867(11):166230.
- 63.ZHAO N,GAO Y H,JIA H T,et al.Anti-apoptosis effect of traditional Chinese medicine in the treatment of cerebral ischemia-reperfusion injury[J].Apoptosis,2023,28(5/6):702-729.
- 64.HASHIDATE-YOSHIDA T,HARAYAMA T,HISHIKAWA D,et al.Fatty acid remodeling by LPCAT3 enriches arachidonate in phospholipid membranes and regulates triglyceride transport[J].Elife,2015,4:e06328.
- 65.DING S Y,DUANMU X Y,XU L S,et al.Ozone pretreatment alleviates ischemia reperfusion injury-induced myocardial ferroptosis by activating the Nrf2/Slc7a11/Gpx4 axis[J].Biomed Pharmacother,2023,165:115185.
- 66.LI Y R,FAN H J,CHAI Z,et al.Effects of Wuzi Yanzong pill on behavior and oxidative stress in Parkinson's disease mice[J].Chin J Tradit Chin Med Pharm,2020,35(6):2795-2799.
- 67.PAN T,XIAO Q,FAN H J,et al.Effect and possible mechanism of Wuzi Yanzong pill on motor function of neurons in Parkinson's disease mice[J].Med J Chin People's Liberation Army,2024,49(5):550-556.
- 68.LI Y R,FAN H J,CHAI Z,et al.Neuroprotective and anti-inflammatory effects of Wuzi Yanzong pills on Parkinson's disease mice[J].Chin J Tradit Chin Med Pharm,2020,35(7):3623-3626.
- 69.ISHII T,WARABI E,MANN G E.Circadian control of BDNF-mediated Nrf2 activation in astrocytes protects dopaminergic neurons from ferroptosis[J].Free Radic Biol Med,2019,133:169-178.
- 70.SUN X,LIANG J Q,HE J C,et al.Neurotrophic factors and the regeneration of dopaminergic neurons in Parkinson's disease[J].Chin J Gerontol,2020,40(13):2904-2908.
- 71.HANG W,FAN S J,LI Y R,et al.Effect of Wuzi Yanzong pill on neurotrophic factors and apoptosis in brain of mice with Parkinson's disease[J].Med J Chin People's Liberation Army,2023,48(2):168-174.
- 72.PALASZ E,WYSOCKA A,GASIOROWSKA A,et al.BDNF as a promising therapeutic agent in Parkinson's disease[J].Int J Mol Sci,2020,21(3):1170.
- 73.KANG S S,WU Z R,LIU X,et al.Treating Parkinson's disease via activation of BDNF/TrkB signaling pathways and inhibition of delta-secretase[J].Neurotherapeutics,2022,19(4):1283-1297.
- 74.JIA D,TANG Y Z,ZHANG J,et al.Therapeutic effect of electroacupuncture combined with Wuzi Yanzong pill on mice with Parkinson's disease by regulating BDNF/TrkB/CREB signaling pathway[J].World Chin Med,2024,19(14):2098-2105.
- 75.ZHI D,XU S,ZHANG L,et al.Shenqi formula delayed Alzheimer's disease-like symptoms by Skn-1 pathway in Caernorhabditis elegans[J].J Ethnopharmacol,2023,316:116741.
- 76.LIN Z Y,YAO M L,ZHENG G Y.Tiaobu Xinshen prescription promotes the Synthesis of Synaptic plasticity-related proteins in 5×FAD transgenic mice with alzheimer's disease by activating the PI3K/Akt/mTOR pathway[J].Tradit Chin Drug Res Clin Pharmacol,2024,35(8):1191-1196.
- 77.LIN Z Y,HUANG T W,HUANG J S,et al.Tiaobu Xinshen recipe(调补心肾方) improved mild cognitive impairment of alzheimer's disease patients with Xin(heart) and Shen(kidney) deficiency[J].Chin J Integr Med,2020,26(1):54-58.
- 78.HUANG S K.Pharmacodynamic evaluation and mechanism of Bushen Yizhi formula in treating Parkinson's disease[D].Guangzhou:Guangzhou Univ Chin Med,2018.
- 79.CHEN Y H,YAN B,GUAN Y,et al.Effect of Erjing pills on learning and memory abilities of AD rats with kidney Yin deficiency induced by ovariectomy+D-galactose combined with Aβ1-40[J].Tradit Chin Drug Res Clin Pharmacol,2019,30(12):1421-1427.
- 80.HUANG L P,QIU X P,YANG X U,et al.Effect of Erjing pill on hippocampal dopaminergic function in AD rats with kidney Yin deficiency induced by ovariectomy + D-galactose combined with Aβ1-40[J].Tradit Chin Drug Res Clin Pharmacol,2021,32(4):479-483.
- 81.HUANG L P,LU L H,YANG X Y,et al.Effect of Erjing pills on alleviating neuroinflammation of AD rats based on TLR4/NF-κB/NLRP3 pathway and its mechanism[J].Chin J Chin Mater Med,2023,48(3):770-777.


