предыдущий|следующий

Исследования прогресса лечения колоректального рака в традиционной китайской медицине на основе сигнального пути AMPK

  • role： First author第一作者
  • Affiliation：

    Henan University of Chinese Medicine， Zhengzhou 450053，China

  • Email：2528856234@qq.com
  • Introduction：胡洋，在读硕士，住院医师，从事消化系统疾病的中西医结合防治及内镜下诊疗研究，E-mail：2528856234@qq.com
HU Yang1,  
  • role： Corresponding author通信作者
  • Affiliation：

    The Second Affiliated Hospital of Henan University of Chinese Medicine， Zhengzhou 450002，China

  • Email：18568228052@163.com
  • Introduction：胡素芹，博士，主治医师，从事消化系统疾病的中西医结合防治及内镜下诊疗研究，E-mail：18568228052@163.com
HU Suqin2*,  
  • Affiliation：

    Henan University of Chinese Medicine， Zhengzhou 450053，China

ZENG Shuo1,  
  • Affiliation：

    The Second Affiliated Hospital of Henan University of Chinese Medicine， Zhengzhou 450002，China

LUO Lei2,  
  • Affiliation：

    The Second Affiliated Hospital of Henan University of Chinese Medicine， Zhengzhou 450002，China

LI Mingyan2,  
  • role： Corresponding author通信作者
  • Affiliation：

    The Second Affiliated Hospital of Henan University of Chinese Medicine， Zhengzhou 450002，China

  • Email：ZhangQS0725@163.com
  • Introduction：张勤生，博士，主任医师，从事消化系统疾病的中西医结合防治及内镜下诊疗研究，E-mail：ZhangQS0725@163.com； *
ZHANG Qinsheng2*

реферат

Колоректальный рак является распространённой злокачественной опухолью пищеварительной системы, и в последние годы наблюдается ежегодный рост заболеваемости и смертности. Из-за сложного патогенеза и неблагоприятного прогноза для пациентов колоректальный рак представляет серьёзную угрозу для физического и психического здоровья человека. В настоящее время западные методы лечения могут в определённой степени подавлять рост опухоли и облегчать симптомы у пациентов, однако проблемы с рецидивами и метастазами после операции, многочисленными побочными эффектами и быстрой выработкой лекарственной устойчивости снижают общую эффективность лечения. Поэтому поиск более эффективных и безопасных методов терапии стал первоочередной задачей. Сигнальный путь аденозинмонофосфат-активируемой протеин киназы (AMPK) играет регуляторную роль в росте, дифференцировке, апоптозе и аутофагии клеток колоректального рака, широко участвуя в развитии заболевания и считается важной мишенью для противораковой терапии. Традиционная китайская медицина (ТКМ) обладает уникальными преимуществами в лечении колоректального рака, действуя через множественные пути и механизмы, способна предотвращать рецидивы и метастазы после операции, снижать побочные эффекты радиохимиотерапии и улучшать качество жизни пациентов, что делает её ключевым методом лечения. Исследования показывают, что активные компоненты китайских лекарственных трав, такие как флавоноиды, полифенолы, терпены и эфиры, а также сложные препараты, например гранулы Циньцзе Фучжэн и некоторые экстракты, оказывают значительное регуляторное влияние на AMPK и связанные с ним сигнальные пути. Они проявляют противораковую активность за счет индукции аутофагии и апоптоза, стимулирования ферроптоза, подавления эпитеально-мезенхимального перехода, обращения лекарственной устойчивости и блокировки клеточного цикла. Данная статья систематизирует и обобщает последние исследования по применению ТКМ в лечении колоректального рака, с акцентом на механизмы регулирования AMPK, и надеется предоставить идеи и рекомендации для разработки новых клинических препаратов.

ключеви́че слова́

аденозинмонофосфат-активируемая протеин киназа (AMPK);сигнальный путь;традиционная китайская медицина;колоректальный рак;прогресс исследований

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