предыдущий|следующий

Прогресс исследований традиционной китайской медицины в лечении сосудистой деменции методом активации ци и кровотока для стимуляции неоваскуляризации

  • role： First author第一作者
  • Affiliation：

    The Second Clinical Medical College， Heilongjiang University of Chinese Medicine， Harbin 150036，China

  • Email：18366365549@163.com
  • Introduction：周振龙，硕士，从事中医老年病、治未病研究，E-mail：18366365549@163.com
ZHOU Zhenlong1,  
  • Affiliation：

    Shandong University of Traditional Chinese Medicine， Jinan 250300，China

DUAN Yu2,  
  • Affiliation：

    Shanghai Haijiang Geriatric Hospital， Shanghai 200080，China

SHA Hongyu3,  
  • role： Corresponding author通信作者
  • Affiliation：

    The Second Clinical Medical College， Heilongjiang University of Chinese Medicine， Harbin 150036，China

    The Fourth Affiliated Hospital of Heilongjiang University of Chinese Medicine， Harbin 150010，China

  • Email：z13936462665@126.com
  • Introduction：周海纯，博士，主任医师，从事中医老年病、治未病研究，E-mail：z13936462665@126.com
ZHOU Haichun14*

реферат

Сосудистая деменция (VaD) является синдромом когнитивных нарушений, вызванным цереброваскулярными поражениями, и занимает второе место среди типов деменции в мире после болезни Альцгеймера. Патологические механизмы VaD сложны и включают в себя процессы неоваскуляризации, нейровоспаления, апоптоза и оксидативного стресса. Неоваскуляризация как ключевой этап патологии VaD регулируется преимущественно через сигнальный путь сосудистого эндотелиального фактора роста (VEGF). В последние годы применение традиционной китайской медицины в лечении VaD привлекает все больше внимания, особенно методика активации ци и кровотока для устранения застойных явлений показала уникальные преимущества в клинической практике. Этот метод основан на теории ци и крови в китайской медицине, акцентируя внимание на гармонизации движения ци и крови для улучшения патологии "кровяного застоя", научное содержание которой постепенно раскрывается в современных фармакологических исследованиях. В статье комбинируется традиционная китайская концепция "устранения застоя и стимулирования новообразования" с механизмом "неоваскуляризации" современной медицины, систематически рассмотрено современное состояние исследований применения метода активации ци и кровотока для стимуляции неоваскуляризации в лечении VaD, включая исследования как отдельных китайских трав, так и комплексных рецептур, способствующих неоваскуляризации, снижению апоптоза и улучшению церебральной гемодинамики через множественные мишени и пути. Кроме того, рассматриваются методы лечения с применением акупунктуры в сочетании с лекарственными средствами, что выходит за рамки традиционной монотерапии. Сочетанное лечение иглоукалыванием и лекарствами не только усиливает эффект неоваскуляризации, но и улучшает когнитивные функции и качество жизни пациентов с VaD через множественные механизмы. Путем сравнительного анализа преимуществ и недостатков современной медицины и традиционной китайской медицины в терапии VaD статья отмечает, что современная медицина преуспевает в изучении патогенеза и целевой терапии, но ограничена в комплексной регуляции и многоцелевом вмешательстве. Традиционная китайская медицина с многокомпонентным и многоцелевым подходом лучше адаптируется к сложной патологии VaD. Однако исследования китайской медицины при VaD имеют ряд недостатков, таких как не полностью определенные механизмы действия и недостаток клинических исследований. В будущем необходимо дальнейшее применение междисциплинарных методов, включая современную фармакологию и молекулярную биологию, для углубленного изучения ресурсов традиционной китайской медицины и разработки комплексных кооперативных лечебных моделей, предлагающих новые идеи и подходы в лечении VaD.

ключеви́че слова́

неоваскуляризация; сигнальный путь сосудистого эндотелиального фактора роста (VEGF); активация ци и кровотока; сосудистая деменция; традиционная китайская медицина

References

  1. 1.
    WOLTERS F J，IKRAM M A.Epidemiology of vascular dementia［J］.Arterioscler Thromb Vasc Biol，2019，39（8）：1542-1549.
  2. 2.
    JIA J，WANG F，WEI C，et al.The prevalence of dementia in urban and rural areas of China［J］.Alzheimers Dement，2014，10（1）：1-9.
  3. 3.
    CHAN E S，BAUTISTA D T，ZHU Y，et al.Traditional Chinese herbal medicine for vascular dementia［J］.Cochrane Database Syst Rev，2018，12（12）：CD010284.
  4. 4.
    FENG X X，CHEN C，QIU J，et al.Effect of Huanglian Jiedu powder in improving brain iron metabolism disorders，myelin damage，and aggressive behavior in VaD mice via regulation of FBXL5/IRP2［J］.Chin J Exp Tradit Med Form，2024，30（24）：1-9.
  5. 5.
    WANG J X，NIE J.Research progress of vascular dementia in traditional Chinese medicine［J］.Neimonggu J Tradit Chin Med，2023，42（2）：140-143.
  6. 6.
    CAO B Q，TAN F.Theory and progress of traditional Chinese medicine based on "phlegm and blood stasis in and spleen and kidney"［J］.Chin Arch Tradit Chin Med，2022，40（5）：62-67.
  7. 7.
    LI Z，LI F C，SU Z J，et al.Progress in research on the mechanism of traditional Chinese medicine in treating vascular cementia［J］.Neimonggu J Tradit Chin Med，2024，43（10）：153-156.
  8. 8.
    DUAN Y，LIU A J.Research progress on the treatment of vascular dementia by promoting blood circulation and removing blood stasis［J］.J Pharm Pract Serv，2025，43（4）：151-155，173.
  9. 9.
    DING H M，LI Y J，QIN H W，et al.Tongmai Kaiqiao pill treat Vascular dementia in rats by regulating mitochondrial autophagy via HIF-1α/BNIP3 signaling pathway［J］.Chin J Exp Tradit Med Form，2024，30（21）：52-60.
  10. 10.
    ZHANG X W，LIU A R，DOU J J.Pathogenesis and treatment of vascular dementia based on integrated traditional Chinese and western medicine：A review［J］.Chin J Exp Tradit Med Form，2023，29（4）：202-211.
  11. 11.
    DICHGANS M，LEYS D.Vascular cognitive impairment［J］.Circ Res，2017，120（3）：573-591.
  12. 12.
    CHEN J，TANG X，CHEN P，et al.Modified bilateral carotid artery ligation to establish a vascular dementia rat model and investigate changes in cerebral blood flow and effects on angiogenesis-related proteins［J］.Acta Lab Anim Sci Sin，2023，31（11）：1423-1430.
  13. 13.
    FANG M，YANG C L，LIU J H.A new study on angiogenesis after myocardial infarction from removing blood stasis［J］.Chin J Integr Med Cardio/Cerebrovasc Dis，2023，21（4）：758-760.
  14. 14.
    KOUREMBANAS S，MARSDEN P A，MCQUILLAN L P，et al.Hypoxia induces endothelin gene expression and secretion in cultured human endothelium［J］.J Clin Invest，1991，88（3）：1054-1057.
  15. 15.
    SCHINELLI S.Pharmacology and physiopathology of the brain endothelin system：An overview［J］.Curr Med Chem，2006，13（6）：627-638.
  16. 16.
    WU M H，HUANG C Y，LIN J A，et al.Endothelin-1 promotes vascular endothelial growth factor-dependent angiogenesis in human chondrosarcoma cells［J］.Oncogene，2014，33（13）：1725-1735.
  17. 17.
    NITTI M，FURFARO A L，MANN G E.Heme oxygenase dependent bilirubin generation in vascular cells：A role in preventing endothelial dysfunction in local tissue microenvironment？［J］.Front Physiol，2020，11：23.
  18. 18.
    DUNN L L，KONG S M Y，TUMANOV S，et al.Hmox1 （heme oxygenase-1） protects against ischemia-mediated injury via stabilization of HIF-1α （hypoxia-inducible factor-1α）［J］.Arterioscler Thromb Vasc Biol，2021，41（1）：317-330.
  19. 19.
    ZHANG H，SHEN W.Research progress on the role of vascular endothelial growth factor in neuropathic pain［J］.Chin J Pain Med，2018，24（1）：49-53.
  20. 20.
    WANG Y L，GAO Y J，ZHONG C Z，et al.Expression and clinical significance of serum miR-34a and VEGF in patients with vascular dementia［J］.J Brain Nerv Dis，2020，28（3）：155-158.
  21. 21.
    WEI Q S，LIANG J，QI M H，et al.Research progress on the mechanism of acupuncture and moxibustion to promote angiogenesis［J］.J Emerg Syndromes Tradit Chin Med，2021，30（2）：369-372.
  22. 22.
    SHAIK F，CUTHBERT G A，HOMER-VANNIASINKAM S，et al.Structural basis for vascular endothelial growth factor receptor activation and implications for disease therapy［J］.Biomolecules，2020，10（12）：1673.
  23. 23.
    YAN F，LIU X，DING H，et al. Paracrine mechanisms of endothelial progenitor cells in vascular repair［J］.Acta Histochem，2022，124（1）：151833.
  24. 24.
    TRITSARIS K，MYREN M，DITLEV S B，et al.IL-20 is an arteriogenic cytokine that remodels collateral networks and improves functions of ischemic hind limbs［J］.Proc Natl Acad Sci U S A，2007，104（39）：15364-15369.
  25. 25.
    DONG Y W，LU L G.The role of angiopoietin/tie system in angiogenesis［J］.J Diagn Concept Pract，2014，13（3）：331-335.
  26. 26.
    PATEL S A，NILSSON M B，LE X，et al.Molecular mechanisms and future implications of VEGF/VEGFR in cancer therapy［J］.Clin Cancer Res，2023，29（1）：30-39.
  27. 27.
    MATSUMOTO T，CLAESSON-WELSH L.VEGF receptor signal transduction［J］.Sci STKE，2001，2001（112）：re21.
  28. 28.
    ZHENG C，LIN Z，ZHAO Z J，et al.MAPK-activated protein kinase-2 （MK2）-mediated formation and phosphorylation-regulated dissociation of the signal complex consisting of p38，MK2，Akt，and Hsp27［J］.J Biol Chem，2006，281（48）：37215-37226.
  29. 29.
    CÔTÉ M C，LAVOIE J R，HOULE F，et al.Regulation of vascular endothelial growth factor-induced endothelial cell migration by LIM kinase 1-mediated phosphorylation of annexin 1［J］.J Biol Chem，2010，285（11）：8013-8021.
  30. 30.
    SAWADA J，LI F，KOMATSU M.R-Ras inhibits VEGF-induced p38 MAPK activation and HSP27 phosphorylation in endothelial cells［J］.J Vasc Res，2015，52（5）：347-359.
  31. 31.
    KISO M，TANAKA S，SAJI S，et al.Long isoform of VEGF stimulates cell migration of breast cancer by filopodia formation via NRP1/ARHGAP17/Cdc42 regulatory network［J］.Int J Cancer，2018，143（11）：2905-2918.
  32. 32.
    HUANG X，ZHOU G，WU W，et al.Editing VEGFR2 blocks VEGF-induced activation of Akt and tube formation［J］.Invest Ophthalmol Vis Sci，2017，58（2）：1228-1236.
  33. 33.
    JIANG B H，LIU L Z.AKT signaling in regulating angiogenesis［J］.Curr Cancer Drug Targets，2008，8（1）：19-26.
  34. 34.
    GERBER H P，CONDORELLI F，PARK J，et al.Differential transcriptional regulation of the two vascular endothelial growth factor receptor genes：Flt-1，but not Flk-1/KDR，is up-regulated by hypoxia［J］.J Biol Chem，1997，272（38）：23659-23667.
  35. 35.
    KOBAYASHI M，NISHITA M，MISHIMA T，et al.MAPKAPK-2-mediated LIM-kinase activation is critical for VEGF-induced actin remodeling and cell migration［J］.EMBO J，2006，25（4）：713-726.
  36. 36.
    NEILL T，SHARPE C，OWENS R T，et al.Decorin-evoked paternally expressed gene 3 （PEG3） is an upstream regulator of the transcription factor EB （TFEB） in endothelial cell autophagy［J］.J Biol Chem，2017，292（39）：16211-16220.
  37. 37.
    FAN Y，LU H，LIANG W，et al.Endothelial TFEB （transcription factor EB） positively regulates postischemic angiogenesis［J］.Circ Res，2018，122（7）：945-957.
  38. 38.
    ROMAY M C，TORO C，IRUELA-ARISPE M L.Emerging molecular mechanisms of vascular dementia［J］.Curr Opin Hematol，2019，26（3）：199-206.
  39. 39.
    PARADISE M B，SACHDEV P S.Vascular cognitive disorder［J］.Semin Neurol，2019，39（2）：241-250.
  40. 40.
    FAN X J，WANG X C.Research progress of traditional Chinese and western medicine in the treatment of cognitive impairment induced by cerebral small vessel disease［J］.Chin Med Mod Dis Educ China，2023，21（20）：199-202.
  41. 41.
    YAN W J，TAN Z H，YANG Q，et al.Modified Shuyu pill ameliorates depressive behaviors and promotes myelin regeneration in mouse model of vascular dementia complicated with depression by regulating energy metabolism of myelin axons via MCT1［J］.Chin J Exp Tradit Med Form，2024，30（19）：21-29.
  42. 42.
    ZHU N，HOU J，MA G，et al.Network pharmacology identifies the mechanisms of action of Shaoyao Gancao decoction in the treatment of osteoarthritis［J］.Med Sci Monit，2019，25：6051-6073.
  43. 43.
    GUAN X，ZHANG L，LI X，et al.Effectiveness comparisons of acupuncture treatments for vascular dementia：A protocol for systematic review and network meta-analysis［J］.Medicine （Baltimore），2021，100（2）：e24079.
  44. 44.
    BATTLE C E，ABDUL-RAHIM A H，SHENKIN S D，et al.Cholinesterase inhibitors for vascular dementia and other vascular cognitive impairments：A network Meta-analysis［J］.Cochrane Database Syst Rev，2021，2（2）：CD013306.
  45. 45.
    KIM Y，KANG D W，KIM G H，et al.Clinical practice guidelines for dementia：Recommendations for cholinesterase inhibitors and memantine［J］.Dement Neurocogn Disord，2025，24（1）：1-23.
  46. 46.
    LIU L J，XIE F，CHEN X Y，et al.Analysis of the effect of rehabilitation therapy on the efficacy and cognitive function of elderly patients with vascular dementia［J］.Chin J Mod Drug Appl，2022，16（4）：245-247.
  47. 47.
    FU H，GONG L S，CHEN L，et al.The influencing factors of cognitive dysfunction in patients with small cerebral vascular disease and the construction of risk prediction model［J］.J.Brain Nerv.Dis，2025，33（3）：181-185.
  48. 48.
    LIU W F，LIN Y，LIU X F，et al.Safety evaluation of Tianzhi granules in treating mild-to-moderate vascular dementia［J］.Chin J Exp Tradit Med Form，2024，30（2）：142-147.
  49. 49.
    YANG K，ZENG L，GE A，et al.Exploring the oxidative stress mechanism of Buyang Huanwu decoction in intervention of vascular dementia based on systems biology strategy［J］.Oxid Med Cell Longev，2021，2021：8879060.
  50. 50.
    SHAO C L，CUI G H，GUO H D.Effects and mechanisms of Taohong Siwu decoction on the prevention and treatment of myocardial injury［J］.Front Pharmacol，2022，13：816347.
  51. 51.
    JI Z J，SHI Y，LI X，et al.Neuroprotective effect of Taohong Siwu decoction on cerebral ischemia/reperfusion injury via mitophagy-NLRP3 inflammasome pathway［J］.Front Pharmacol，2022，13：910217.
  52. 52.
    HE R，HE F，HU Z，et al.Analysis of potential mechanism of herbal formula Taohong Siwu decoction against vascular dementia based on network pharmacology and molecular docking［J］.Biomed Res Int，2023，2023：1235552.
  53. 53.
    YAN H L，ZHAO Y，FANG X，et al.Study on the mechanism of Tongqiao Huoxue decoction in the treatment of vascular dementia after cerebral infarction based on network pharmacology［J］.Chin Tradit Pat Med，2021，43（1）：255-263.
  54. 54.
    LIAN J H，ZHOU X Q，LIN D Q，et al.Efficacy and safety of Tongqiao Huoxue decoction for vascular dementia：A Meta-analysis［J］.Intern Med J Pract Tradit Chin Med Sci，2020，34（11）：55-61.
  55. 55.
    CHEN L，WANG X F.Advances in pathological mechanism of vascular dementia［J］.Chongqing Med，2015，44（26）：3709-3711.
  56. 56.
    CARMELIET P.Angiogenesis in life，disease and medicine［J］.Nature，2005，438（7070）：932-936.
  57. 57.
    GUO H，LI L，HOU J C，et al.Advance in prevention and treatment of ischemia cardio-cerebrovascular disease through increased therapeutic angiogenesis induced by traditional Chinese medicine［J］.China J Chin Mater Med，2015，40（1）：24-28.
  58. 58.
    LIU J H，LI Y，JIANG L，et al.Effects of modified Tongqiao Huoxue decoction on cognitive function and ET-1 and VEGF angiogenesis factors in rats with vascular dementia［J］.Lishizhen Med Mater Med Res，2022，33（4）：857-860.
  59. 59.
    PAN R，CAI J，ZHAN L，et al.Buyang Huanwu decoction facilitates neurorehabilitation through an improvement of synaptic plasticity in cerebral ischemic rats［J］.BMC Complement Altern Med，2017，17（1）：173.
  60. 60.
    JI Z J.Effect and mechanism of Taohong Siwu decoction on learning and memory ability of vascular dementia rats［D］.Hefei：Anhui University of Chinese Medicine，2015.
  61. 61.
    HAN L，JI Z，CHEN W，et al.Protective effects of tao-Hong-si-wu decoction on memory impairment and hippocampal damage in animal model of vascular dementia［J］.Evid Based Complement Alternat Med，2015，2015：195835.
  62. 62.
    XIN J J，YANG Y.Research progress on the relationship between neuronal apoptosis and vascular dementia［J］.J Med Res Combat Trauma Care，2023，36（3）：324-327.
  63. 63.
    WANG Y，ZHANG H.Research progress of Chinese medicine in treating vascular dementia by regulating neuronal apoptosis［J］.Acta Chin Med，2022，37（8）：1630-1637.
  64. 64.
    WANG X X，ZHANG B，XIA R，et al.Inflammation，apoptosis and autophagy as critical players in vascular dementia［J］.Eur Rev Med Pharmacol Sci，2020，24（18）：9601-9614.
  65. 65.
    DUAN Y，LI H，DONG X，et al.VEGF mitigates bisphosphonate-induced apoptosis and differentiation inhibition of MC3T3-E1 cells［J］.Exp Ther Med，2022，23（2）：130.
  66. 66.
    FARZANEH B M，GHOLAMI S Z，ASGHARI S M.Apoptosis induction in human lung and colon cancer cells via impeding VEGF signaling pathways［J］.Mol Biol Rep，2022，49（5）：3637-3647.
  67. 67.
    ZHOU Y，ZHU X，CUI H，et al.The role of the VEGF family in coronary heart disease［J］.Front Cardiovasc Med，2021，8：738325.
  68. 68.
    ZHOU M，ZHA Z，ZHENG Z，et al.Cordycepin suppresses vascular inflammation，apoptosis and oxidative stress of arterial smooth muscle cell in thoracic aortic aneurysm with VEGF inhibition［J］.Int Immunopharmacol，2023，116：109759.
  69. 69.
    YU H Y.Effect of Buyang Huanwu decoction on nerve cell apoptosis in rats with vascular dementia based on IGF-1-PI3K-Akt-FoxO1 pathway［D］.Nanchang：Jiangxi University of Chinese Medicine，2023.
  70. 70.
    LIU H M，LI Y L，LIU H，et al.Effect of Tongqiao Huoxue decoction on learning，memory and hippocampus PI3K/Akt signal pathway in vascular dementia rats［J］.Chin J Exp Tradit Med Form，2023，doi：.
  71. 71.
    PENG K Y，GU J F，SU S L，et al.Salvia miltiorrhiza stems and leaves total phenolic acids combination with tanshinone protect against DSS-induced ulcerative colitis through inhibiting TLR4/PI3K/Akt/mTOR signaling pathway in mice［J］.J.Ethnopharmacol，2021，264：113052.
  72. 72.
    QIAN S Y.Danshensu alleviates nerve cell damage in vascular dementia mice by improving brain microcirculation disorder［D］.Harbin：Heilongjiang University of Chinese Medicine，2018.
  73. 73.
    WANG W，HU W.Salvianolic acid B recovers cognitive deficits and angiogenesis in a cerebral small vessel disease rat model via the STAT3/VEGF signaling pathway［J］.Mol Med Rep，2018，17（2）：3146-3151.
  74. 74.
    XU X，WU L，ZHOU X，et al.Cryptotanshinone inhibits VEGF-induced angiogenesis by targeting the VEGFR2 signaling pathway［J］.Microvasc Res，2017，111：25-31.
  75. 75.
    SHI C G，YANG Y S，LI H，et al.Tanshinol protects hippocampus and attenuates vascular dementia development［J］.J Asian Nat Prod Res，2014，16（6）：667-676.
  76. 76.
    DENG L.Application rule of turmeric in the clinic of encephalopathy and observation of curative effect of turmeric yizhi capsule in the treatment of vascular dementia with phlegm and blood stasis syndrome［D］.Changsha：Hunan University of Chinese Medicine，2017.
  77. 77.
    ZHANG R，ZHAO T，ZHENG B，et al.Curcumin derivative Cur20 attenuated cerebral ischemic injury by antioxidant effect and HIF-1α/VEGF/TFEB-activated angiogenesis［J］.Front Pharmacol，2021，12：648107.
  78. 78.
    ZHENG Y，ZHANG J，ZHAO Y，et al.Curcumin protects against cognitive impairments in a rat model of chronic cerebral hypoperfusion combined with diabetes mellitus by suppressing neuroinflammation，apoptosis，and pyroptosis［J］.Int Immunopharmacol，2021，93：107422.
  79. 79.
    YAN Q D，PENG B，MA D C，et al.Research progress of Shichangpu（Acori Tatarinowii Rhizoma）-Chuanxiong（Chuanxiong Rhizoma） medicine pair on the improvement of vascular dementia［J］.J Liaoning Univ Tradit Chin Med，2024，26（11）：153-157.
  80. 80.
    HU M L，LI F，QIU S H，et al.Effect of acupuncture and moxibustion and moxibustion on vascular dementia and hemorheology and serum inflammatory factors［J］.Clin J Tradit Chin Med，2024，36（1）：133-138.
  81. 81.
    VARFOLOMEEV E E，ASHKENAZI A.Tumor necrosis factor：An apoptosis JuNKie？［J］.Cell，2004，116（4）：491-497.
  82. 82.
    BALKWILL F.Tumour necrosis factor and cancer［J］.Nat Rev Cancer，2009，9（5）：361-371.
  83. 83.
    KARIN M，GALLAGHER E.TNFR signaling：Ubiquitin-conjugated TRAFfic signals control stop-and-go for MAPK signaling complexes［J］.Immunol Rev，2009，228（1）：225-240.
  84. 84.
    LIANG B，ZHAO K，MA X D，et al.Experimental study on anti-apoptotic effect and mechanism of ligustrazine on neurons of cerebral ischemia-reperfusion injury rats［J］.Chin Arch Tradit Chin Med，2022，40（6）：205-209，288-289.
  85. 85.
    HIROHATA S，ABE A，MURASAWA A，et al.Differential effects of IL-6 blockade tocilizumab and TNF inhibitors on angiogenesis in synovial tissues from patients with rheumatoid arthritis［J］.Mod Rheumatol，2017，27（5）：766-772.
  86. 86.
    SHIN M R，KANG S K，KIM Y S，et al.TNF-α and LPS activate angiogenesis via VEGF and SIRT1 signalling in human dental pulp cells［J］.Int Endod J，2015，48（7）：705-716.
  87. 87.
    CHENG C Y，HO T Y，LEE E J，et al.Ferulic acid reduces cerebral infarct through its antioxidative and anti-inflammatory effects following transient focal cerebral ischemia in rats［J］.Am J Chin Med，2008，36（6）：1105-1119.
  88. 88.
    WAN F，NIU X，SONG Y L，et al.The role of Chinese herbs and acupuncture on the inflammation reaction after cerebral ischemia［J］.Curr Pharm Des，2016，22（6）：709-719.
  89. 89.
    XING R，ZHANG S X.Warming acupuncture combined with electroacupuncture in the treatment of primary dysmenorrhea of cold coagulation and blood stasis type［J］.Jilin J Tradit Chin Med，2020，40（4）：542-545.
  90. 90.
    ZHANG C M，WU T S，WANG Y Y，et al.Effect analysis of acupuncture in the treatment of dysmenorrhea in endometriosis with Qi deficiency and blood stasis［J］.J Tianjin Univ Tradit Chin Med，2024，43（5）：439-443.
  91. 91.
    LAI Z，ZHANG Q，LIANG L，et al.Efficacy and mechanism of moxibustion treatment on mild cognitive impairment patients：An fMRI study using ALFF［J］.Front Mol Neurosci，2022，15：852882.
  92. 92.
    WANG C N，LIU F，LIU Y.Research progress of the treatment of vascular dementia by acupuncture and moxibustion of points on GV［J］.Henan Tradit Chin Med，2022，42 （11）：1758-1765.
  93. 93.
    ZOU K X，YONG Q Z，ZHAI J J.Analysis of YANG Jun's academic thought on the prevention and treatment of vascular dementia by moxibustion［J］.J Anhui Univ Chin Med，2018，37（2）：37-39.
  94. 94.
    ZHAO R，ZHANG L H，GU X R，et al.Analysis on the treatment of cerebrovascular diseases by acupuncture prescription guided by the theory of nutritive and defensive Qi of meridian theory［J］.J Shanxi Coll Tradit Chin Med，2024，25（5）：563-567.
  95. 95.
    LI F，WANG Y，JIANG T X，et al.Acupuncture and moxibustion for vascular dementia and its effect on serum VEGF and AChE［J］.Chin Acupunct Moxib，2021，41（8）：851-854.
  96. 96.
    ZHANG T，WANG L P，WANG G L，et al.Effects of moxibustion on symptoms of mild cognitive impairment：protocol of a systematic review and meta-analysis［J］.BMJ Open，2020，10（4）：e033910.
  97. 97.
    LIU Y，YU Z，JIANG J F，et al.Exploration on acupuncture regulation pathways based on neurovascular coupling［J］.Acupunct Res，2022，47（1）：83-87.
  98. 98.
    ZOU R.Effects of electroacupuncture preconditioning on cerebral fossa protein-1 and blood-brain barrier permeability in rats with cerebral ischemia-reperfusion［D］.Nanjing：Nanjing University of Chinese Medicine，2014.
  99. 99.
    ZHOU J X，GAO H S，LIU Q，et al.Effects of "Tongdu Tiaoshen" acupuncture pretreatment on learning and memory function and hippocampal angiogenesis in VD rats［J］.J Clin Acupunct Moxib，2023，39（2）：74-80.
  100. 100.
    GAO Y L，TIAN H M，CHEN C T，et al.Effect of acupuncture technique of Tiaoxin Tongdu on learning-memory ability and expressions of hippocampal VEGF and Ang-1 in rats with vascular dementia［J］.Chin Acupunct Moxib，2020，40（10）：1108-1112.
  101. 101.
    SHI H X，LI H M，GUO Y，et al.Clinical efficacy of Fuyuan capsules combined with Xingnao Kaiqiao acupuncture on vascular dementia and effects on serum VEGF，Hcy，and BDNF［J］.World J Integr Tradit West Med，2022，17（5）：941-944，949.
  102. 102.
    HE J.Research status of acupuncture and mesenchymal stem cells in vascular dementia and prospects of combination therapy［J］.Biomed Eng Clin Med，2021，25（5）：644-649.
  103. 103.
    ZHANG M，LU D Q，WU W W，et al.Effect of Huayu Tongluo moxibustion on the expression of VEGF and bFGF protein in HUVEC-12 cells of VD rats in vitro［J］.Mod Chin Dr，2020，58（33）：33-37，193.
  104. 104.
    PENG F，WANG R P.Effect of butylphthalide soft capsule combined with citicoline sodium in the treatment of senile vascular dementia［J］.China Mod Med，2022，29（31）：86-89，93.
  105. 105.
    LIANG Q Y，LI Z M.Effects of Tongdu Tiaoshen acupuncture combined with Buyang Huanwu decoction on hemorheology and cognitive function in patients with vascular dementia［J］.Jiangxi J Tradit Chin Med，2022，53（1）：51-53.
  106. 106.
    WANG Y G，ZHOU C Y，REN H M，et al.Effect of electroacupuncture combined with modified Buyang Huanwu decoction on memory behavior，serum BDNF，VEGF and neuronal apoptosis related molecule expression in patients with vascular dementia［J］.Chin Arch Tradit Chin Med，2022，40（5）：81-84，268.
  107. 107.
    WEI B，WU S，WANG Z，et al.Comparison of cognitive performance and cardiac function between three different rat models of vascular dementia［J］.Neuropsychiatr Dis Treat，2022，18：19-28.
  108. 108.
    LIU J，LI Q，PENG T，et al.Assessment of four serum biochemical markers in elderly patients with vascular dementia after cerebral infarction and their response to donepezil and idebenone［J］.J Neurol Surg B Skull Base，2022，84（6）：629-636.

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