предыдущий|следующий

Исследовательский прогресс в лечении гормонального некроза головки бедренной кости за счет регуляции активными компонентами Epimedium связанных сигнальных путей

  • role： First author第一作者
  • Affiliation：

    Changchun University of Chinese Medicine，Changchun 130117，China

  • Email：1415634742@qq.com
  • Introduction：常敬宣，在读硕士，从事中西医结合骨科学研究，E-mail：1415634742@qq.com
CHANG Jingxuan1,  
  • Affiliation：

    Changchun University of Chinese Medicine，Changchun 130117，China

WU Jinyao1,  
  • Affiliation：

    The Third Clinical Hospital Affiliated to Changchun University of Chinese Medicine，Changchun 130117，China

JIN Meiying2,  
  • Affiliation：

    Changchun University of Chinese Medicine，Changchun 130117，China

MENG Fanqi1,  
  • role： Corresponding author通信作者
  • Affiliation：

    Affiliated Hospital of Changchun University of Chinese Medicine，Changchun 130021，China

  • Email：6177252@163.com
  • Introduction：赵文海，硕士，教授，主任医师，从事中医骨伤科学研究，Tel：0431-86177836，E-mail：6177252@163.com； *
ZHAO Wenhai3*,  
  • role： Corresponding author通信作者
  • Affiliation：

    The Third Clinical Hospital Affiliated to Changchun University of Chinese Medicine，Changchun 130117，China

  • Email：345738991@qq.com
  • Introduction：崔镇海，博士，副主任医师，从事中西医结合骨科学研究，Tel：0431-89912516，E-mail：345738991@qq.com
CUI Zhenhai2*

реферат

Гормональный некроз головки бедренной кости (SANFH) — это заболевание костно-суставной системы, вызванное длительным и массовым использованием гормонов. Типичные патологические признаки включают прогрессирующее нарушение кровоснабжения головки бедренной кости, что приводит к апоптозу остеоцитов и некрозу костной ткани. По мере прогрессирования заболевания развивается деформация и коллапс структуры головки бедра, что серьезно влияет на функциональность конечностей и качество жизни пациентов. Глюкокортикоиды вызывают патологическое повреждение через двойной механизм: с одной стороны, подавляют дифференцировку остеобластов и активируют образование остеокластов, нарушая баланс между образованием и резорбцией кости; с другой стороны, индуцируют нарушения липидного обмена, подавляют ангиогенез и повреждают функцию эндотелиальных клеток, вызывая микроциркуляторные нарушения. Традиционные китайские травы Epimedium и их активные компоненты демонстрируют многомерное регулятивное действие в профилактике и лечении SANFH. Изучение литературы показало, что эти травы содержат множество активных веществ, включая общее флавоноиды Epimedium, икарин, икариозид, кемпферол, икариозид II. Они регулируют ключевые сигнальные пути, такие как Wnt/β-катенин, TGF-β/BMP/Smad, MAPK, PI3K/Akt, OPG/RANKL/RANK, обеспечивая гомеостаз костного метаболизма, регуляцию ангиогенеза, коррекцию нарушения липидного обмена и регуляцию аутофагии клеток. Настоящая статья систематически описывает механизмы вмешательства активных компонентов Epimedium в ключевые патологические этапы SANFH через указанные сигнальные пути и подробно анализирует их регуляцию ключевых узлов между различными путями с целью предоставить основы для клинического лечения и дальнейших экспериментальных исследований.

ключеви́че слова́

Epimedium;активные компоненты;гормональный некроз головки бедра;патологический механизм;сигнальные пути;костный обмен

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