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Progreso en la investigación de los efectos de los componentes y el mecanismo de acción de Da Cheng Qi Tang en el tratamiento del accidente cerebrovascular

  • role： First author第一作者
  • Affiliation：

    School of Basic Medical Sciences， Hengyang Medical School， University of South China， Hengyang 421001， China

  • Email：1971809250@qq.com
  • Introduction：严易之，在读硕士，从事中药神经药理学的研究，E-mail：1971809250@qq.com
YAN Yizhi1,  
  • Affiliation：

    School of Basic Medical Sciences， Hengyang Medical School， University of South China， Hengyang 421001， China

LIU Xinyi1,  
  • Affiliation：

    School of Basic Medical Sciences， Hengyang Medical School， University of South China， Hengyang 421001， China

DUAN Yang1,  
  • Affiliation：

    School of Basic Medical Sciences， Hengyang Medical School， University of South China， Hengyang 421001， China

LONG Miaoqing1,  
  • Affiliation：

    Chenzhou No.1 People's Hospital， Chenzhou 423000， China

LI Chaoya2,  
  • Affiliation：

    School of Basic Medical Sciences， Hengyang Medical School， University of South China， Hengyang 421001， China

LI Qiang1,  
  • Affiliation：

    School of Basic Medical Sciences， Hengyang Medical School， University of South China， Hengyang 421001， China

CHEN Yi'an1,  
  • Affiliation：

    School of Basic Medical Sciences， Hengyang Medical School， University of South China， Hengyang 421001， China

YANG Shasha1,  
  • role： Corresponding author通信作者
  • Affiliation：

    School of Basic Medical Sciences， Hengyang Medical School， University of South China， Hengyang 421001， China

  • Email：2021000048@usc.edu.cn
  • Introduction：张月，博士，讲师，从事中药药理学研究，E-mail：2021000048@usc.edu.cn
ZHANG Yue1*,  
  • role： Corresponding author通信作者
  • Affiliation：

    School of Basic Medical Sciences， Hengyang Medical School， University of South China， Hengyang 421001， China

  • Email：zengp@usc.edu.cn
  • Introduction：曾鹏，博士，校聘教授，从事中药神经药理学研究，E-mail：zengp@usc.edu.cn； *
ZENG Peng1*

resumen

El accidente cerebrovascular es la principal causa de muerte y discapacidad en adultos en China, con una alta tasa de incidencia, discapacidad, mortalidad y recurrencia. El potencial de la medicina china tradicional para el tratamiento y las secuelas del accidente cerebrovascular es enorme. El famoso fármaco clásico de la medicina china, Da Cheng Qi Tang, ha sido utilizado durante mucho tiempo y ha demostrado ser efectivo en el tratamiento del accidente cerebrovascular. En la práctica clínica, Da Cheng Qi Tang se utiliza comúnmente para tratar el accidente cerebrovascular y sus secuelas, pero se necesita mejorar la cantidad y la calidad de los ensayos clínicos de Da Cheng Qi Tang para el tratamiento del accidente cerebrovascular, y su investigación básica es débil. Los componentes efectivos no están claros, y el mecanismo de acción de múltiples objetivos no está claro. El equipo de investigación ha demostrado anteriormente que Da Cheng Qi Tang puede revertir eficazmente el daño neurológico y reducir la acumulación de hierro, así como reducir los niveles de citoquinas proinflamatorias en ratas con accidente cerebrovascular hemorrágico. El mecanismo está relacionado con la vía de señalización mediada por el factor de transcripción nuclear 2 relacionado con la eritroide 2 (Nrf2) y la activación de las células de la microglía mediada por la señal de la proteína quinasa activada por mitógenos p38 (p38 MAPK). Para aclarar la base de la eficacia de Da Cheng Qi Tang, el mecanismo de acción en el tratamiento del accidente cerebrovascular, este documento resume el progreso de la investigación clínica sobre el efecto de Da Cheng Qi Tang en el accidente cerebrovascular, la evaluación de la seguridad y la investigación de los componentes sanguíneos para el tratamiento del accidente cerebrovascular. El documento resume 45 componentes químicos de plantas principales de Da Cheng Qi Tang, de los cuales 11 son componentes sanguíneos confirmados, y entre ellos, la emodina, el ácido emódico, el emodina glucósido, el aloína emodina, el sinvergüenza, el hesperidina, la naringina, el hinokiol, y el hinokiol pueden servir como marcadores de calidad (Q-Marker) para Da Cheng Qi Tang. El mecanismo de acción de Da Cheng Qi Tang en el tratamiento del accidente cerebrovascular es complejo e incluye la regulación de la respuesta inflamatoria, el daño neuronal, el estrés oxidativo, la barrera hematoencefálica, los factores neurotróficos de origen cerebral, la agregación plaquetaria, etc. Este documento contribuye a una comprensión más profunda de la base de eficacia y el mecanismo de acción del tratamiento con Da Cheng Qi Tang para el accidente cerebrovascular, proporcionando una base teórica para la aplicación clínica de Da Cheng Qi Tang en el tratamiento del accidente cerebrovascular y el desarrollo de medicamentos para el accidente cerebrovascular.

palabra clave

Da Cheng Qi Tang; accidente cerebrovascular; base de eficacia; marcador de calidad (Q-Marker); mecanismo de acción

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