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Terapia cíclica para mejorar la función renal y hepática y la regulación de la reproducción para el tratamiento del síndrome de los ovarios poliquísticos (SOPQ) en el período de ventana de implantación en ratas:

  • role： First author第一作者
  • Affiliation：

    Hunan University of Chinese Medicine， Changsha 410208， China

    Key Laboratory of Hunan Province for Integrated Traditional Chinese and Western Medicine on Prevention and Treatment of Cardio-Cerebral Diseases， Hunan University of Chinese Medicine， Changsha 410208， China

  • Email：784586293@qq.com
  • Introduction：刘泉，在读硕士，从事中西医妇科疑难病症防治研究，E-mail：784586293@qq.com
LIU Quan12,  
  • Affiliation：

    Hunan University of Chinese Medicine， Changsha 410208， China

HE Yiqing1,  
  • Affiliation：

    Hunan University of Chinese Medicine， Changsha 410208， China

ZHANG Ying1,  
  • Affiliation：

    Hunan University of Chinese Medicine， Changsha 410208， China

WANG Xi1,  
  • role： Corresponding author通信作者
  • Affiliation：

    Hunan University of Chinese Medicine， Changsha 410208， China

  • Email：42180672@qq.com
  • Introduction：杨硕，博士，副教授，从事妇科疑难病症防治研究，E-mail：42180672@qq.com
YANG Shuo1*

resumen

El objetivo de este estudio es observar el efecto de la terapia cíclica en la función renal y hepática y la regulación de la reproducción para el tratamiento del síndrome de los ovarios poliquísticos (SOPQ) en el período de ventana de implantación en ratas. 6 de 36 ratas macho y hembra de nivel SPF fueron seleccionadas para formar un grupo natural aleatorio para las demás ratas y se les administró una dosis de quinona para construir un modelo animal de SOPQ. Las divisiones se realizaron mediante la tabla de números aleatorios para formar un grupo natural, un grupo modelo, un grupo de intervención (11.97 / 28.35 g × kg -1), un grupo de mezcla de tres granos (8 × 10 -3 mg × kg -1), un ciclo grupo terapéutico (11.97 / 28.35 g × kg -1) y un grupo de aspirina (8 × 10 -3 mg × kg -1), durante 12 días, es decir 3 ciclos de estro, después de que el tratamiento terminara, la pareja fue colocada en una sola jaula. Se tomaron muestras de las hembras en el 5º día de gestación para calcular el número de folículos implantados de cada grupo adyuvante y medir el número total de glándulas en el útero mediante la tinción de hematoxilina-eosina (HE) y la prueba de inmunoabsorción enzimática (ELISA) para medir los niveles de estradiol (E 2) y progesterona (P) en la sangre, la prueba de inmunoabsorción enzimática (ELISA) para medir los niveles de estradiol (E

palabra clave

Síndrome de ovario poliquístico;Capacidad uterina;MiR-140-5P;factor de crecimiento del endotelio;terapia cíclica

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