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Bù zhōng yì qì tāng mejora la expresión de SFTPC y las lesiones pulmonares en ratones CIH

  • role： First author第一作者
  • Affiliation：

    Hebei University of Chinese Medicine， Shijiazhuang 050200， China

    Hebei Technology Innovation Center of TCM Combined with Hydrogen Medicine， Shijiazhuang 050091， China

  • Email：zlyao452470@163.com
  • Introduction：张璐瑶，在读硕士，从事睡眠呼吸暂停并发症的机制及中医药防治研究，E-mail：zlyao452470@163.com
ZHANG Luyao12,  
  • Affiliation：

    Hebei University of Chinese Medicine， Shijiazhuang 050200， China

    Hebei Technology Innovation Center of TCM Combined with Hydrogen Medicine， Shijiazhuang 050091， China

WANG Yangjing12,  
  • Affiliation：

    Hebei University of Chinese Medicine， Shijiazhuang 050200， China

    Hebei Technology Innovation Center of TCM Combined with Hydrogen Medicine， Shijiazhuang 050091， China

LIU Bingbing12,  
  • role： Corresponding author通信作者
  • Affiliation：

    Hebei University of Chinese Medicine， Shijiazhuang 050200， China

    Hebei Technology Innovation Center of TCM Combined with Hydrogen Medicine， Shijiazhuang 050091， China

  • Email：lijr666@sina. com
  • Introduction：李杰茹，教授，硕士生导师，从事睡眠呼吸暂停并发症的机制及中医药防治研究，E-mail：lijr666@sina. com
LI Jieru12*

resumen

El objetivo del estudio es investigar el efecto de la fórmula Bù zhōng yì qì tāng en la mejora de la expresión anormal de la proteína C surfactante pulmonar (SFTPC) inducida por la hipoxia intermitente crónica (CIH) y la mejora de las lesiones pulmonares. Método 40 ratones machos adultos SPF C57BL/6 saludables se seleccionaron al azar y se dividieron en 5 grupos experimentales: grupo oxígeno normal, grupo CIH, grupo dosis baj as, medias y altas de la fórmula Bù zhōng yì qì tāng, 8 en cada grupo. Durante la modelización, los ratones del grupo oxígeno normal se colocaron en un entorno de concentración estándar de oxígeno, mientras que los ratones de los grupos CIH y dosis bajas, medias y altas de la fórmula Bù zhōng yì qì tāng se colocaron en una cámara hipóxica y se elevaron durante 8 horas al día, durante 35 días. Antes de cada elevación, los ratones de los grupos dosis bajas, medias y altas de la fórmula Bù zhōng yì qì tāng recibieron las dosis correspondientes de la fórmula (8,1, 16,2, 32,4 g·kg-1·d-1), mientras que los ratones de los grupos oxígeno normal y CIH recibieron cada día dosis equivalentes de solución salina por vía oral. El registro del estado general de los ratones antes y después de la experiencia, se utilizó un sistema de en equipo para detectar la función pulmonar de cada grupo de ratones.

palabra clave

Bù zhōng yì qì tāng; hipoxia intermitente; estrés endoplásmico; proteína C de superficie pulmonar

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