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Análisis de modelos animales para la disminución de la reserva ovárica basados en las características clínicas de síndromes chinos y occidentales

  • role： First author第一作者
  • Affiliation：

    Dongzhimen Hospital， Beijing University of Chinese Medicine， Beijing 100700， China

  • Email：1481034625@qq.com
  • Introduction：于明玥，在读博士，从事卵巢储备功能减退疾病的相关研究，E-mail：1481034625@qq.com
YU Mingyue,  
  • role： Corresponding author通信作者
  • Affiliation：

    Dongzhimen Hospital， Beijing University of Chinese Medicine， Beijing 100700， China

  • Email：tangling73@126.com
  • Introduction：汤玲，博士，主任医师，博士生导师，从事中医药防治妇科疾病相关研究，Tel：010-84013040，E-mail：tangling73@126.com
TANG Ling*,  
  • Affiliation：

    Dongzhimen Hospital， Beijing University of Chinese Medicine， Beijing 100700， China

SUN Xiaohui,  
  • Affiliation：

    Dongzhimen Hospital， Beijing University of Chinese Medicine， Beijing 100700， China

ZHAO Jingjing

resumen

Con el desarrollo de la sociedad y el aumento de la demanda de embarazo a edad avanzada en mujeres, la disminución de la reserva ovárica (DOR) ha recibido una atención cada vez mayor. Esta enfermedad no solo afecta el ciclo menstrual normal de las mujeres, sino que también amenaza su salud mental. Actualmente, la investigación sobre la DOR se encuentra en una etapa preliminar, y la construcción de un modelo animal efectivo y realista es una necesidad urgente para avanzar en la investigación de la DOR. Este estudio utiliza la literatura existente combinada con los estándares de diagnóstico de la medicina china y occidental para resumir, analizar y evaluar los modelos existentes, proporcionando una referencia para optimizar los modelos animales de DOR. Método: análisis retrospectivo de la literatura sobre modelos animales relacionados con la DOR, revisión de los estándares de diagnóstico chinos y occidentales, evaluación del grado de coincidencia clínica entre medicina china y occidental según los métodos de evaluación de modelos animales. Resultados: los modelos animales de DOR incluyen factores naturales, médicos, inmunológicos, metabólicos y ambientales. Entre ellos, los modelos médicos, especialmente los inducidos por preparaciones de Tripterygium wilfordii, ciclofosfamida y cisplatino, tienen un alto grado de coincidencia tanto en las enfermedades occidentales como en los tipos de síndromes chinos, siendo el método óptimo para modelar DOR en la investigación actual. Conclusión: la mayoría de los métodos actuales para modelar la DOR tienen un alto grado de coincidencia clínica con las enfermedades occidentales, mientras que hay pocos modelos animales de DOR con síndromes chinos claramente definidos. En la búsqueda de tratamientos para la DOR, no se puede ignorar el papel de la medicina china, por lo que se debe desarrollar más activamente modelos animales de DOR relacionados con los síndromes chinos para explorar mejor el potencial de la medicina china y proporcionar un sólido apoyo teórico para la aplicación de la medicina china en el tratamiento de la DOR.

palabra clave

disminución de la reserva ovárica;modelo animal;combinación síndromes y enfermedades

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