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Mejora del metabolismo de la glucosa y los lípidos, así como del estrés oxidativo en ratas con síndrome de ovario poliquístico mediante Guinenshen Plus y activación de la vía AMPK/Akt/Nrf2

  • role： First author第一作者
  • Affiliation：

    The First Affiliated Hospital of Chongqing Medical University， Chongqing 400016， China

  • Email：592807496@qq.com
  • Introduction：田珈瑜，博士，从事内分泌紊乱与免疫损伤疾病的临床及基础研究，E-mail：592807496@qq.com
TIAN Jiayu,  
  • Affiliation：

    The First Affiliated Hospital of Chongqing Medical University， Chongqing 400016， China

QIN Wenyi,  
  • Affiliation：

    The First Affiliated Hospital of Chongqing Medical University， Chongqing 400016， China

YANG Juan,  
  • role： Corresponding author通信作者
  • Affiliation：

    The First Affiliated Hospital of Chongqing Medical University， Chongqing 400016， China

  • Email：cyrxf@163.com
  • Introduction：荣晓凤，硕士，教授，从事风湿免疫疾病的临床与基础研究，E-mail：cyrxf@163.com
RONG Xiaofeng*

resumen

El objetivo de este estudio es explorar el mecanismo de acción de las cápsulas Guinenshen Plus para mejorar el metabolismo de la glucosa y los lípidos, así como el estrés oxidativo en ratas con síndrome de ovario poliquístico (SOP) a través de la vía de activación de la proteína quinasa/activina/factor 2 relacionado con el adenosín monofosfato (AMPK/Akt/Nrf2). El modelo de ratas con SOP se estableció mediante la administración intravenosa de fenilbutirato a una dosis de 1 mg/kg durante 21 días. Las ratas se dividieron en un grupo de modelo, un grupo de metformina (0,25 g/kg) y tres grupos con dosis baja, media y alta de Guinenshen Plus (4,01, 8,02 y 16,04 g/kg/día), con 8 ratas en cada grupo, y un grupo control de 10 ratas. Se administraron dosis apropiadas de medicamentos a los grupos tratados, mientras que a los grupos de control y modelo se les administraron volúmenes equivalentes de solución salina fisiológica, de forma continua durante 4 semanas.

palabra clave

síndrome de ovario poliquístico;Guinenshen Plus;estrés oxidativo;proteína quinasa/activina/factor 2 relacionado con el adenosín monofosfato (AMPK);activina (Akt);factor 2 relacionado con el adenosín monofosfato (Nrf2)

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