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Progreso en la investigación sobre el tratamiento de enfermedades del sistema nervioso con la composición de raíz amarga, corteza de cassia seca y jengibre

  • role： First author第一作者
  • Affiliation：

    School of Basic Medical Sciences， Heilongjiang University of Chinese Medicine， Harbin 150040， China

  • Email：hg142@qq.com
  • Introduction：郝格，在读硕士，从事方剂学文献研究，E-mail：hg142@qq.com
HAO Ge,  
  • role： Corresponding author通信作者
  • Affiliation：

    School of Basic Medical Sciences， Heilongjiang University of Chinese Medicine， Harbin 150040， China

  • Email：gaochangyu1971@163.com
  • Introduction：高长玉，博士，教授，硕士生导师，从事方剂学文献研究，E-mail：gaochangyu1971@163.com
GAO Changyu*,  
  • Affiliation：

    School of Basic Medical Sciences， Heilongjiang University of Chinese Medicine， Harbin 150040， China

PAN Zexin

resumen

Las enfermedades del sistema nervioso tienen un amplio espectro, y en los últimos años la incidencia y la mortalidad aumentan, representando una seria amenaza para la salud y la vida de los pacientes. La fórmula de Zhongjing, una composición de raíz amarga, corteza de cassia seca y jengibre, se utiliza ampliamente en la clínica, con buenas propiedades de relajación del yang poco, calentamiento del bazo, disipación del frío, humectación y prevención del yin. Estudios clínicos han demostrado que el uso de una composición de raíz amarga, corteza de cassia seca y jengibre, o su combinación con agujas, moxas, medicamentos occidentales en el tratamiento del insomnio, depresión, ansiedad, mareos, dolores de cabeza, síndrome premenopáusico, neuropatía periférica en pacientes diabéticos, inestabilidad de la región posterior al accidente cerebrovascular, trastorno bipolar, irritabilidad en los niños, la eficacia del tratamiento es significativa, los efectos secundarios son mínimos, la seguridad es alta. Las investigaciones farmacológicas modernas indican que las composiciones de raíz amarga, corteza de cassia seca y los principales componentes activos de las fórmulas como la saponina de chabapola, el estrógeno, el aldehído de canela, el flavanol amarillo, el flavanol hong, la gingerol, el 6-gingerol, el ácido glicirrízico, el glicirrizina, pueden pasar a través de múltiples blancos, desarrollar estrés oxidativo, reducir la inflamación nerviosa, regular los niveles de neurotransmisores, luchar contra la muerte de hierro, regular los niveles de estrógeno, regular la plasticidad de las sinapsis nerviosas, regular los niveles de autofagia de las células nerviosas, inhibir la activación de las microglías, regular el metabolismo de la glucosa, inhibir la apoptosis de las células nerviosas y otras acciones. Este artículo, basado en la síntesis de la literatura pertinente en los últimos años, tiene como objetivo organizar el tratamiento de las enfermedades del sistema nervioso utilizando la composición de raíz amarga, corteza de cassia seca y jengibre y estudiar los mecanismos de acción, así como proporcionar recomendaciones adecuadas con el fin de proporcionar orientación para investigaciones en profundidad y estudios de revisión posteriores.

palabra clave

Composiciones de raíz amarga, corteza de cassia seca y jengibre; enfermedades del sistema nervioso; progreso en la investigación; aplicación clínica; mecanismos de acción

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