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El control de calidad de las mitocondrias regula el mecanismo de aparición de las miopatías y el tratamiento chino tradicional: desarrollo de la investigación

  • role： First author第一作者
  • Affiliation：

    The First Affiliated Hospital of Henan University of Chinese Medicine，Zhengzhou 450000，China

    The First Clinical Medical School of Henan University of Chinese Medicine，Zhengzhou 450046，China

  • Email：1065242806@qq.com
  • Introduction：代婷，在读博士，从事常见功能障碍中医康复的临床与基础研究，E-mail：1065242806@qq.com
DAI Ting12,  
  • Affiliation：

    The First Affiliated Hospital of Henan University of Chinese Medicine，Zhengzhou 450000，China

    The First Clinical Medical School of Henan University of Chinese Medicine，Zhengzhou 450046，China

CHEN Yan12,  
  • Affiliation：

    Graduate School of Heilongjiang University of Chinese Medicine，Harbin 150040，China

GUO Changsheng3,  
  • Affiliation：

    The First Affiliated Hospital of Henan University of Chinese Medicine，Zhengzhou 450000，China

GAO Jing1,  
  • role： Corresponding author通信作者
  • Affiliation：

    The First Affiliated Hospital of Henan University of Chinese Medicine，Zhengzhou 450000，China

  • Email：fxd0502@163.com
  • Introduction：冯晓东，博士生导师，主任医师，从事常见功能障碍中医康复的临床与基础研究，E-mail：fxd0502@163.com
FENG Xiaodong1*

resumen

La miopatía es un síndrome clínico caracterizado principalmente por una disminución de la fuerza y la masa muscular esquelética, a menudo acompañada de caídas, pérdida de función, debilidad y otros resultados adversos. El mecanismo de aparición de la miopatía es complejo, y los estudios han demostrado que los trastornos del control de la calidad de las mitocondrias son un factor patológico importante que conduce a la aparición y desarrollo de la miopatía. La medicina tradicional china, gracias a sus ventajas en el control multiobjetivo, multirruta de las mitocondrias, es ampliamente apreciada por regular la estabilidad del entorno interno de las mitocondrias y tratar las miopatías. La medicina tradicional china puede inhibir el estrés oxidativo de las mitocondrias, regular el equilibrio dinámico de las mitocondrias, inhibir la autofagia mitocondrial, estimular la biosíntesis mitocondrial, prevenir la apoptosis mitocondrial, mantener la estabilidad del calcio y las proteínas mitocondriales e inhibir la degradación mitocondrial, desempeñando así un papel en la prevención y el tratamiento de las miopatías. Sobre esta base, este artículo examina la relación entre el control de la calidad de las mitocondrias y la miopatía, así como el mecanismo de acción de la medicina tradicional china en el tratamiento de las miopatías al regular el sistema de control de calidad de las mitocondrias, con el fin de ofrecer nuevas orientaciones para el tratamiento de las miopatías mediante la medicina tradicional china y proporcionar una base teórica para la investigación clínica sobre la intervención de la medicina tradicional china en el tratamiento de las miopatías.

palabra clave

Control de calidad de las mitocondrias; autofagia; apoptosis; miopatía; mecanismo de acción; medicina tradicional china; desarrollo de la investigación

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