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Avances en la investigación de modelos animales de la enfermedad pulmonar obstructiva crónica y la intervención con medicina tradicional china

  • role： First author第一作者
  • Affiliation：

    Liaoning University of Traditional Chinese Medicine（TCM）， Shenyang 110847，China

  • Email：2097893477@qq.com
  • Introduction：邹吉宇，在读博士，从事中医药治疗肺系疾病的基础和临床研究，E-mail：2097893477@qq.com
ZOU Jiyu1,  
  • Affiliation：

    The Affiliated Hospital of Liaoning University of TCM， Shenyang 110000，China

PANG Lijian2,  
  • Affiliation：

    The Affiliated Hospital of Liaoning University of TCM， Shenyang 110000，China

WANG Tianjiao2,  
  • Affiliation：

    The Affiliated Hospital of Liaoning University of TCM， Shenyang 110000，China

ZANG Ningzi2,  
  • Affiliation：

    The Affiliated Hospital of Liaoning University of TCM， Shenyang 110000，China

ZHAO Zhongxue2,  
  • Affiliation：

    The Affiliated Hospital of Liaoning University of TCM， Shenyang 110000，China

LIU Yongming2,  
  • Affiliation：

    Liaoning University of Traditional Chinese Medicine（TCM）， Shenyang 110847，China

SI Qi1,  
  • Affiliation：

    Liaoning University of Traditional Chinese Medicine（TCM）， Shenyang 110847，China

CAO Tianya1,  
  • Affiliation：

    Liaoning University of Traditional Chinese Medicine（TCM）， Shenyang 110847，China

MA Xuenan1,  
  • Affiliation：

    Liaoning University of Traditional Chinese Medicine（TCM）， Shenyang 110847，China

WANG Ying1,  
  • role： Corresponding author通信作者
  • Affiliation：

    Liaoning University of Traditional Chinese Medicine（TCM）， Shenyang 110847，China

  • Email：1548739538@qq.com
  • Introduction：王佳然，博士，从事中医肺系疾病基础和临床研究，E-mail：1548739538@qq.com； *
WANG Jiaran1*,  
  • role： Corresponding author通信作者
  • Affiliation：

    Liaoning University of Traditional Chinese Medicine（TCM）， Shenyang 110847，China

  • Email：deanoftcm@126.com
  • Introduction：吕晓东，博士，主任医师，教授，博士生导师，从事中医肺系疾病基础和临床研究，E-mail：deanoftcm@126.com
LYU Xiaodong1*

resumen

La enfermedad pulmonar obstructiva crónica (EPOC), como una de las tres principales causas de muerte en el mundo, es una enfermedad sistémica compleja con alta prevalencia, alta mortalidad, alta discapacidad, múltiples exacerbaciones agudas y diversas comorbilidades extrapulmonares. Su mecanismo patogénico es complejo, y la medicina occidental aún no posee un tratamiento específico efectivo que la cure por completo. La medicina tradicional china, con su característica de múltiples componentes y múltiples objetivos, tiene una ventaja significativa en el tratamiento de la EPOC mediante intervenciones múltiples en varios eslabones, vías y mecanismos. Por tanto, utilizar la teoría, principios y fórmulas de la medicina tradicional china para explorar la esencia de la EPOC y descubrir medicamentos efectivos es un foco importante en la investigación moderna. Los modelos animales son fundamentales en la investigación médica. Seleccionar animales apropiados y aplicar métodos razonables para reproducir modelos animales estables que imiten las manifestaciones clínicas y características fisiopatológicas de la EPOC, así como usar métodos de evaluación adecuados para determinar el éxito del modelo, son las principales preocupaciones en la investigación experimental. Observar la intervención de la medicina tradicional china sobre los modelos animales de EPOC y explorar las vías y mecanismos específicos mediante los cuales actúa, así como descubrir monómeros, hierbas individuales y fórmulas efectivas, constituyen el núcleo de la investigación experimental. Actualmente, los estudios sobre modelos animales de EPOC se centran principalmente en el establecimiento de modelos, evaluación, observación del efecto y exploración de mecanismos. En los últimos años no se han realizado revisiones sistemáticas ni actualizaciones sobre la intervención de la medicina tradicional china en modelos animales de EPOC. Este estudio revisa la selección de animales del modelo, los métodos para establecer modelos animales de EPOC, los métodos de evaluación y las intervenciones de la medicina tradicional china, resumiendo la situación actual, identificando problemas para mejorar futuros estudios y proporcionando evidencia y apoyo para la investigación científica y el tratamiento clínico de la EPOC.

palabra clave

enfermedad pulmonar obstructiva crónica (EPOC);modelo animal;medicina tradicional china;combinación de enfermedad-síntoma;evaluación del modelo

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