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Progreso en la investigación sobre el tratamiento de la necrosis avascular de la cabeza femoral inducida por hormonas mediante la regulación de vías de señalización asociadas por componentes activos de Epimedium

  • role： First author第一作者
  • Affiliation：

    Changchun University of Chinese Medicine，Changchun 130117，China

  • Email：1415634742@qq.com
  • Introduction：常敬宣，在读硕士，从事中西医结合骨科学研究，E-mail：1415634742@qq.com
CHANG Jingxuan1,  
  • Affiliation：

    Changchun University of Chinese Medicine，Changchun 130117，China

WU Jinyao1,  
  • Affiliation：

    The Third Clinical Hospital Affiliated to Changchun University of Chinese Medicine，Changchun 130117，China

JIN Meiying2,  
  • Affiliation：

    Changchun University of Chinese Medicine，Changchun 130117，China

MENG Fanqi1,  
  • role： Corresponding author通信作者
  • Affiliation：

    Affiliated Hospital of Changchun University of Chinese Medicine，Changchun 130021，China

  • Email：6177252@163.com
  • Introduction：赵文海，硕士，教授，主任医师，从事中医骨伤科学研究，Tel：0431-86177836，E-mail：6177252@163.com； *
ZHAO Wenhai3*,  
  • role： Corresponding author通信作者
  • Affiliation：

    The Third Clinical Hospital Affiliated to Changchun University of Chinese Medicine，Changchun 130117，China

  • Email：345738991@qq.com
  • Introduction：崔镇海，博士，副主任医师，从事中西医结合骨科学研究，Tel：0431-89912516，E-mail：345738991@qq.com
CUI Zhenhai2*

resumen

La necrosis avascular de la cabeza femoral inducida por hormonas (SANFH) es una enfermedad osteoarticular causada por el uso prolongado y en grandes cantidades de hormonas. Sus características patológicas típicas incluyen un trastorno progresivo en la circulación sanguínea del sistema de suministro de la cabeza femoral, lo que conduce a la apoptosis de osteocitos y la necrosis de la estructura ósea. A medida que avanza la enfermedad, se produce el colapso y necrosis estructural de la cabeza femoral, afectando gravemente la función de las extremidades y la calidad de vida diaria del paciente. Los glucocorticoides medían el daño patológico a través de un mecanismo dual: por un lado, inhiben la diferenciación de osteoblastos y activan la formación de osteoclastos, rompiendo el equilibrio dinámico entre la formación y absorción ósea; por otro lado, inducen trastornos del metabolismo lipídico, inhiben la angiogénesis y dañan la función de las células endoteliales, provocando trastornos en la microcirculación. La medicina tradicional china, especialmente la Epimedium y sus componentes activos, muestra efectos reguladores multidimensionales en la prevención y tratamiento de SANFH. La revisión de la literatura revela que contiene múltiples componentes activos, principalmente flavonoides totales, icariina, icariside, kaempferol e icariside II, que actúan a través de múltiples vías de señalización clave como Wnt/β-catenina, TGF-β/BMP/Smad, MAPK, PI3K/Akt, OPG/RANKL/RANK, desempeñando funciones reguladoras en la homeostasis del metabolismo óseo, la angiogénesis, la corrección de trastornos del metabolismo lipídico y la regulación de la autofagia celular. Este artículo explica sistemáticamente el mecanismo de intervención de los componentes activos de la Epimedium en las etapas patológicas clave de SANFH a través de estas vías, y analiza en profundidad la regulación de los nodos clave entre diferentes vías señalizadoras, con el fin de proporcionar una referencia para futuros tratamientos clínicos e investigaciones experimentales.

palabra clave

Epimedium;componentes activos;necrosis avascular de la cabeza femoral inducida por hormonas;mecanismo patológico;vías de señalización;metabolismo óseo

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