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Avances en la investigación del tratamiento de la artritis reumatoide con Danggui Niantong Tang

  • role： First author第一作者
  • Affiliation：

    Henan University of Chinese Medicine， Zhengzhou 450046， China

  • Email：zhouenhui0519@163.com
  • Introduction：周恩慧，在读博士，从事仲景理法方药防治风湿免疫病的临床研究，E-mail：zhouenhui0519@163.com；
ZHOU Enhui,  
  • Affiliation：

    Henan University of Chinese Medicine， Zhengzhou 450046， China

CHE Zhiying,  
  • role： Corresponding author通信作者
  • Affiliation：

    Henan University of Chinese Medicine， Zhengzhou 450046， China

  • Email：654467475@qq.com
  • Introduction：王振亮，博士，教授，主任医师，博士生导师，从事仲景理法方药防治风湿免疫病的临床研究，E-mail：654467475@qq.com；*
WANG Zhenliang*,  
  • role： Corresponding author通信作者
  • Affiliation：

    Henan University of Chinese Medicine， Zhengzhou 450046， China

  • Email：xuerping1228@163.com
  • Introduction：许二平，博士，教授，主任医师，博士生导师，从事方剂配伍及作用机制规律研究，E-mail：xuerping1228@163.com
XU Erping*

resumen

La artritis reumatoide (AR) es una enfermedad autoinmune sistémica crónica caracterizada por poliartritis simétrica, que a largo plazo puede causar deformidades articulares y pérdida funcional, reduciendo gravemente la calidad de vida de los pacientes. La fórmula Danggui Niantong Tang, originaria del "Yiyuan" de Zhang Yuansuan de la dinastía Jin, posee efectos de eliminar el calor y la humedad, disipar el viento y aliviar el dolor, siendo una fórmula clásica para tratar el síndrome de obstrucción por humedad y calor en AR. El autor, mediante la búsqueda en bases de datos CNKI, WanFang y PubMed, integró y revisó la eficacia clínica y los estudios experimentales del Danggui Niantong Tang en el tratamiento de AR, exponiendo su mecanismo de acción con la esperanza de proporcionar una referencia útil para futuras investigaciones clínicas y básicas en el campo de AR. Los estudios clínicos demuestran que Danggui Niantong Tang puede mejorar los síntomas centrales en pacientes con AR tipo obstrucción por humedad y calor, como inflamación y dolor articular, rigidez matutina y restricción de movimiento, disminuir marcadores de actividad inflamatoria como proteína C reactiva y velocidad de sedimentación, y promover la recuperación postoperatoria tras reemplazo de rodilla en pacientes con AR; cuando se combina con medicamentos occidentales como el metotrexato, puede potenciar el efecto antiinflamatorio y reducir efectos adversos como irritación gastrointestinal y daño hepático. Los estudios experimentales revelan que esta fórmula regula la red de factores inflamatorios, promueve la apoptosis de células sinoviales, inhibe la autofagia anormal de estas células, suprime la angiogénesis sinovial y regula la homeostasis de la microbiota intestinal. Sin embargo, las investigaciones actuales presentan limitaciones como la calidad clínica insuficiente, relaciones interactivas de mecanismos no claras y falta de optimización de formas farmacéuticas, requiriendo futuros estudios clínicos de alta calidad, exploraciones multi-ómicas del mecanismo y mejoras en las formulaciones para proveer una base científica para su promoción clínica e investigación profunda.

palabra clave

Danggui Niantong Tang;artritis reumatoide;síndrome de obstrucción por humedad y calor;eficacia clínica;estudios experimentales

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