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中国中医科学院 广安门医院,北京 100053
Received:13 January 2025,
Accepted:08 February 2025,
Published Online:08 February 2025,
Published:05 April 2025
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王阶,李军,董艳等.泛血管疾病的中医内涵及防治策略[J].中国实验方剂学杂志,2025,31(07):1-14.
WANG Jie,LI Jun,DONG Yan,et al.Connotation and Prevention Strategies of Traditional Chinese Medicine for Panvascular Diseases[J].Chinese Journal of Experimental Traditional Medical Formulae,2025,31(07):1-14.
王阶,李军,董艳等.泛血管疾病的中医内涵及防治策略[J].中国实验方剂学杂志,2025,31(07):1-14. DOI: 10.13422/j.cnki.syfjx.20250726.
WANG Jie,LI Jun,DONG Yan,et al.Connotation and Prevention Strategies of Traditional Chinese Medicine for Panvascular Diseases[J].Chinese Journal of Experimental Traditional Medical Formulae,2025,31(07):1-14. DOI: 10.13422/j.cnki.syfjx.20250726.
泛血管疾病以血管病变为共同病理特征,主要表现为动脉粥样硬化,危害心、脑、肾及四肢等重要器官,是当前中国居民的首要死因之一。既往由于学科分支较细,各个学科过度关注局部的病变,导致泛血管疾病作为一个全身系统性疾病的重要性被临床忽视。泛血管疾病在病理上的整体性、防治上的综合性和个体性使得其十分契合中医整体观和辨证论治。中医认为血瘀是动脉粥样硬化的核心病机,且贯穿动脉粥样硬化全过程。通过中医“血脉”“经络”“藏象”和“脏腑-经络”理论,有助于全面理解泛血管疾病的复杂性,提供更加系统的治疗方案。泛血管疾病中医证候存在“痰瘀滞虚”演变,泛血管动脉粥样硬化与“瘀、痰”证候相关,治法以活血化痰为主,针对冠状动脉粥样硬化、脑动脉粥样硬化、肾动脉粥样硬化性狭窄分别有不同的具体药物和作用机制。泛血管静脉病变与中医“虚、瘀”证候相关,中医治法以益气活血为主,可以达到抑制静脉血栓形成、改善静脉性溃疡、抗静脉内皮损伤的作用。泛血管微循环病变与中医“滞、瘀”密不可分,治法以行气通络为主,对冠脉微血管病变、糖尿病微血管病变、肺微血管病变、胰腺微血管病变均有良好疗效。泛血管淋巴管病变与中医“水、瘀”证候相关,治法以活血利水为主,可以达到促进淋巴管生成、增强淋巴液回流的作用。此外,中医药结合现代科技,特别是人工智能的应用,可以提升早期识别和个性化治疗的效率,实现泛血管疾病的早期筛查和综合管理。由此可见,中医药防治泛血管疾病将大有可为。
Panvascular disease, with vascular diseases as the common pathological feature, is mainly manifested as atherosclerosis. Panvascular disease mainly affects the important organs of the heart, brain, kidney, and limbs. It is one of the leading causes of death for Chinese residents at present. Previously, due to the narrow branches of disciplines, too much attention was paid to local lesions, resulting in the neglect of panvascular disease as a systemic one. The fact that panvascular disease has overall pathology and comprehensive and individualized treatment strategies, makes the disease highly compatible with the principles of holism concept and syndrome differentiation and treatment in traditional Chinese medicine (TCM). It is believed that blood stasis is the core pathogenesis of atherosclerosis and is involved in the whole process of atherosclerosis. The theories of ''blood vessel'', ''meridians'', ''visceral manifestation'', and ''organs-meridians'' in TCM are helpful to comprehensively understand the complexity of panvascular diseases. Moreover, those theories can provide systematic treatment strategies. The TCM syndromes of panvascular diseases evolve from ''phlegm, stasis, stagnation, and deficiency''. Panvascular arteriosclerosis is related to the syndrome of ''stasis and phlegm'', and the treatment mainly promotes blood circulation and removes phlegm. There are different specific drugs and mechanisms of action for coronary atherosclerosis, cerebral atherosclerosis, and renal artery atherosclerotic stenosis. Panvascular venous lesions are related to the syndrome of ''deficiency and stasis'' in TCM, and the TCM treatment mainly invigorates Qi and promotes blood circulation, which can inhibit venous thrombosis, improve venous ulcers, and resist venous endothelial damage. Panvascular microcirculatory lesions are inseparable from the ''stagnation and stasis'' in TCM, and the treatment mainly promotes Qi and dredges collaterals, which has a good effect on coronary microvascular lesions, diabetic microvascular lesions, pulmonary microvascular lesions, and pancreatic microvascular lesions. Panvascular lymphatic lesions are related to the syndrome of ''water and stasis'' in TCM. The treatment method focuses on promoting blood circulation and water excretion, which can promote lymphangiogenesis and enhance lymphatic reflux. In addition, the combination of TCM and modern technology, especially the application of artificial intelligence, can improve the efficiency of early identification and personalized treatment, resulting in early screening and comprehensive management of panvascular diseases. Therefore, TCM will play a vital role in the prevention and treatment of panvascular diseases.
杨靖 , 张英梅 , 葛均波 . 泛血管疾病防控——从疾病治疗到综合管理 [J] . 中华心血管病杂志 , 2021 , 4 ( 1 ) : 1 - 6 .
YANG J , ZHANG Y M , GE J B . Prevention and control of pan-vascular diseases: From disease treatment to comprehensive management [J]. Chin J Cardiol , 2021 , 4 ( 1 ): 1 - 6 .
YU H , XIE Y , LAN L , et al . Sirt7 protects against vascular calcification via modulation of reactive oxygen species and senescence of vascular smooth muscle cells [J]. Free Radic Biol Med , 2024 , 223 : 30 - 41 .
HU Y , ZHAO Y , DAI N , et al . Unwavering excellence: How to be a competent cardiovascular doctor in "panvascular medicine" [J]. Innovation (Camb) , 2023 , 4 ( 5 ): 100489 .
KOTTE A N , VAN LEEUWEN G M , LAGENDIJK J J . Modelling the thermal impact of a discrete vessel tree [J]. Phys Med Biol , 1999 , 44 ( 1 ): 57 - 74 .
杨靖 , 张英梅 , 葛均波 . 泛血管疾病的筛查和早期发现 [J]. 上海医学 , 2022 , 45 ( 5 ): 293 - 297 .
YANG J , ZHANG Y M , GE J B . SCreening and early detection of panvascular disease [J]. Shanghai Med J , 2022 , 45 ( 5 ): 293 - 297 .
BHATT D L , STEG P G , OHMAN E M , et al . REACH Registry Investigators. International prevalence, recognition, and treatment of cardiovascular risk factors in outpatients with atherothrombosis [J]. JAMA , 2006 , 295 ( 2 ): 180 - 189 .
PAN Y , JING J , CAI X , et al . Prevalence and vascular distribution of multiterritorial atherosclerosis among community-dwelling adults in southeast China [J]. JAMA Netw Open , 2022 , 5 ( 6 ): e2218307 .
LI Z , YANG H , ZHANG W , et al . Prevalence of asymptomatic carotid artery stenosis in Chinese patients with lower extremity peripheral arterial disease:A cross-sectional study on 653 patients [J]. BMJ Open , 2021 , 11 ( 4 ): 42926 .
中国医师协会心血管内科医师分会 . 泛血管疾病抗栓治疗中国专家共识(2024版) [J] . 中华医学杂志 , 2024 , 104 ( 12 ) : 906 - 923 .
Chinese Medical Association Cardiovascular Physician Branch . Chinese expert consensus on antithrombotic therapy for pan vascular disease (2024 edition) [J]. Chin Med J , 2024 , 104 ( 12 ): 906 - 923 .
ALBERTS M J , BHATT D L , MAS J L , et al . Three-year follow-up and event rates in the international REduction of Atherothrombosis for Continued Health Registry [J]. Eur Heart J , 2009 ( 19 ): 2318 - 2326 .
ZHANG Z Y , HU C F , WANG M X , et al . Research on mechanism of PCS in damaging vascular endothelial cells and promoting formation of atherosclerosis via TLR4/TREM-1 [J]. Eur Rev Med Pharmacol Sci , 2018 , 22 ( 21 ): 7533 - 7542 .
李军 , 孙语男 , 王阶 . 基于“血管-脏腑-证治”防治泛血管疾病的中医思考 [J]. 中国实验方剂学杂志 , 2024 , 30 ( 10 ): 187 - 195 .
LI J , SUN Y N , WANG J . Thinking of traditional Chinese medicine in prevention and treatment of panvascular diseases ''blood vessel-zangfu organ-syndrome differentiation and treatment'' [J]. Chin J Exp Tradit Med Form , 2024 , 30 ( 10 ): 187 - 195 .
魏姝琳 , 周泳雯 , 徐索文 , 等 . 泛血管疾病危险因素及其互作 [J]. 生物医学转化 , 2024 , 5 ( 4 ): 113 - 124 .
WEI S L , ZHOU Y W , XU S W , et al . Risk factors of pan-vascular diseases and their interactions [J]. Biomed Transform , 2024 , 5 ( 4 ): 113 - 124
张仕衡 , 苏嘉楠 , 杨宇峰 , 等 . “血瘀证”视角下2型糖尿病合并泛血管疾病的关系 [J]. 世界中医药 , 2024 , 19 ( 11 ): 1644 - 1648 .
ZHANG S H , SU J N , YANG Y F , et al . Relationship between type 2 diabetes mellitus complicated with panvascular disease from perspective of "blood stasis syndrome" [J]. World Chin Med , 2024 , 19 ( 11 ): 1644 - 1648 .
韩景辉 . 动脉粥样硬化疾病的中医新认识 [J]. 中医研究 , 2010 , 23 ( 5 ): 11 - 13 .
HAN J H . New understanding of atherosclerosis in traditional Chinese medicine [J]. Res Tradit Chin Med , 2010 , 23 ( 5 ): 11 - 13 .
尹玉洁 , 马柳一 , 张军芳 , 等 . 脉络学说指导的通心络治疗动脉粥样硬化的进展 [J]. 中国老年学杂志 , 2016 , 36 ( 7 ): 1760 - 1762 .
YIN Y J, MA L Y, ZHANG J F, et al Progress of Tongxinluo in the treatment of atherosclerosis guided by the venation theory [J]. Chin J Gerontol , 2016 , 36 ( 7 ): 1760 - 1762 .
杨彤 , 姚秋菊 , 陈勇 , 等 . 基于“虚、痰、瘀、毒”理论探讨颈动脉粥样硬化 [J]. 亚太传统医药 , 2024 , 20 ( 5 ): 215 - 218 .
YANG T , YAO Q J , CHEN Y , et al . Discussion on carotid atherosclerosis based on the theory of deficiency, phlegm, blood stasis and poison [J]. Asia - Pac J Tradit Med , 2024 , 20 ( 5 ): 215 - 218 .
王椿野 , 赵振武 , 李新龙 , 等 . 基于现代文献的动脉粥样硬化中医病机研究 [J]. 环球中医药 , 2013 , 6 ( 2 ): 92 - 95 .
WANG C Y, ZHAO Z W,LI X L,et al, Distribution of TCM syndrome factors of atherosclerosis based on modern literature [J]. Global Tradit Chin Med , 2013 , 6 ( 2 ): 92 - 95 .
吴丹 , 葛召波 , 刘贯龙 , 等 . 活血化瘀经方防治动脉粥样硬化探析 [J]. 中国中医药现代远程教育 , 2024 , 22 ( 12 ): 56 - 59 .
WU D , GE Z B , LIU G L , et al . Activating blood and removing stasis classical prescription in the prevention and treatment of atherosclerosis [J]. Chin Med Mod Distance Educ China , 2024 , 22 ( 12 ): 56 - 59 .
陈寅萤 , 王阶 . 王阶从“虚-痰-瘀-热-滞”论治冠状动脉狭窄经验 [J]. 辽宁中医杂志 , 2024 , 51 ( 10 ): 29 - 33 .
CHEN Y Y , WANG J . WANG Jie's experience in treatment of coronary artery stenosis from perspective of ''deficiency-phlegm-blood stasis-heat-stagnation'' [J]. Liaoning J Tradit Chin Med , 2024 , 51 ( 10 ): 29 - 33 .
陈可冀 , 李连达 , 翁维良 , 等 . 血瘀证与活血化瘀研究 [J]. 中西医结合心脑血管病杂志 , 2005 , 3 ( 1 ) : 1 - 2 .
CHEN K J , LI L D , WENG W L , et al . Study on blood stasis syndrome and activating blood and removing stasis [J]. Chin J Integr Med Cardio-Cerebrovasc Dis , 2005 , 3 ( 1 ) : 1 - 2 .
任耀龙 , 陈玲 , 杨磊 , 等 . 冠心病合并颈动脉粥样硬化斑块形成病人中医证素分布规律研究 [J]. 中西医结合心脑血管病杂志 , 2019 , 17 ( 19 ): 2881 - 2885 .
REN Y L , CHEN L , YANG L , et al . The research on distribution of Chinese medicine syndrome factor in patients of coronary heart disease with carotid atherosclerotic plaque formation [J]. Chin J Integr Med Cardio-Cerebrovasc Dis , 2019 , 17 ( 19 ): 2881 - 2885 .
马倩 , 韩丽蓓 , 刘俊丽 . 动脉粥样硬化性心脑血管疾病中医证素分布规律临床研究 [J]. 现代中医临床 , 2017 , 24 ( 3 ): 25 - 27,43 .
MA Q , HAN L B , LIU J L . The clinical study of traditional Chinese medicine syndrome elements distribution of atherosclerotic cardiovascular disease [J]. Tradit Chin Med , 2017 , 24 ( 3 ): 25 - 27,43 .
GUO R , LI L , SU J , et al . Pharmacological activity and mechanism of tanshinone Ⅱ A in related diseases [J]. Drug Des Devel Ther , 2020 , 14 : 4735 - 4748 .
王曼曼 . 血府逐瘀汤抗动脉粥样硬化的胞葬作用机制研究 [D]. 北京 : 北京中医药大学 , 2021 .
WANG M M . Study on the mechanism of anti atherosclerotic efferocytosis of Xuefu Zhuyu decoction [D]. Beijing : Beijing University of Chinese Medicine , 2021 .
周欣欣 , 李娟 , 高雅 , 等 . 补阳还五汤黄芪不同配比组方调控动脉粥样硬化炎性反应的分子机制研究 [J]. 中华中医药学刊 , 2022 , 40 ( 11 ):171-175, 289 - 291 .
ZHOU X X , LI J , GAO Y , et al . Molecular mechanism of Buyang Huanwu decoction with different dosages of Huangqi(Astragali Radix) regulating inflammatory response of atherosclerosis [J]. China Arch Tradit Chin Med , 2022 , 40 ( 11 ):171-175, 289 - 291 .
盛松 , 张艳虹 , 马杭琨 , 等 . 活血化瘀中药防治冠状动脉粥样硬化性心脏病的作用机制研究进展 [J]. 中西医结合心脑血管病杂志 , 2022 , 20 ( 5 ): 863 - 866 .
SHENG S , ZHANG Y H , MA H K , et al . Research progress on the mechanism of traditional Chinese medicine for activating blood circulation and removing blood stasis in the prevention and treatment of coronary atherosclerotic heart disease [J]. Chin J Integr Med Cardio-Cerebrovascuiar Dis , 2022 , 20 ( 5 ): 863 - 866 .
陈星宇 , 王月 , 苏卓异 , 等 . 活血化瘀法治疗缺血性脑卒中的研究进展 [J]. 中西医结合心脑血管病杂志 , 2022 , 20 ( 16 ): 2958 - 2961 .
CHEN X Y , WANG Y , SU Z Y , et al . Research progress in the treatment of ischemic stroke with the method of activating blood circulation and removing blood stasis [J]. Chin J Integr Med Cardio-Cerebrovasc Dis , 2022 , 20 ( 16 ): 2958 - 2961 .
张宇 , 武晓妹 , 董叶朋 , 等 . 从痰瘀论治慢性肾脏病微炎症状态的研究进展 [J]. 河北中医药学报 , 2021 , 36 ( 6 ): 49 - 52,62 .
ZHANG Y , WU X M , DONG Y P , et al . Research progress on treatment of microinflammation of chronic kidney disease from phlegm and stasis [J]. Hebei Tradit Chin Med Pharm , 2021 , 36 ( 6 ): 49 - 52,62 .
贺爽 , 朱彦 . 活血化瘀中药治疗糖尿病外周动脉疾病的研究进展和临床应用前景 [J]. 天津中医药 , 2017 , 34 ( 3 ): 145 - 149 .
HE S , ZHU Y . Recent advance and clinical application potential of blood-activating and stasis-removing Chinese medicine for diabetic peripheral artery disease [J]. Tianjin Tradit Chin Med , 2017 , 34 ( 3 ): 145 - 149 .
王震 , 郑波 , 张方霞 , 等 . 通心络胶囊结合非洛地平治疗冠心病心绞痛的疗效及对NT-pro BNP、sCD105水平的影响 [J]. 中华中医药学刊 , 2021 , 39 ( 12 ): 193 - 196 .
WANG Z , ZHENG B , ZHANG F X , et al . Effect of Tongxinluo capsule combined with felodipine in treatment of angina pectoris of coronary heart disease and its influence on levels of NT-pro BNP and sCD105 [J]. China Arch Tradit Chin Med , 2021 , 39 ( 12 ): 193 - 196 .
陈寅萤 , 王阶 . 王阶教授从肾虚血瘀论治冠心病经验 [J]. 中国中医急症 , 2024 , 33 ( 9 ): 1661 - 1664,1668 .
CHEN Y Y , WANG J . Professor Wang Jie's experience in treating coronary heart disease from kidney deficiency and blood stasis [J]. J emerg Tradit Chin Med , 2024 , 33 ( 9 ): 1661 - 1664,1668 .
张云锋 . 宽胸理气疏肝法辨治冠心病心绞痛的临床疗效 [J]. 临床医学研究与实践 , 2017 , 2 ( 18 ): 120 - 121 .
ZHANG Y F . Effect of relieving chest, regulating Qi and smoothing liver treatment on angina pectoris and coronary heart disease [J]. Clin Res and Pract , 2017 , 2 ( 18 ): 120 - 121 .
包艺运 , 杨建梅 , 李佳维 . 柴胡疏肝散加减联合西医常规疗法治疗冠心病稳定型心绞痛(心血瘀阻)对中医证候及血清细胞因子的影响 [J]. 四川中医 , 2023 , 41 ( 11 ): 97 - 100 .
BAO Y Y , YANG J M , LI J W . Effect of Chaihu Shugan powder combined with conventional western medicine in the treatment of stable angina pectoris of coronary heart disease (heart blood stasis) on TCM syndromes and serum cytokines [J]. Sichuan J Tradit Chin Med , 2023 , 41 ( 11 ): 97 - 100 .
洪霞 , 王旭杰 , 李秋艳 , 等 . 翁维良疏肝活血方治疗冠心病冠状动脉介入治疗术后合并焦虑经验 [J]. 北京中医药 , 2019 , 38 ( 6 ): 564 - 567 .
HONG X , WANG X J , LI Q Y , et al . WENG Weiliang's experience of Shugan Huoxue decoction in treating anxiety after percutaneous coronary intervention for coronary heart disease [J]. Beijing J Tradit Chin Med , 2019 , 38 ( 6 ): 564 - 567 .
尤良震 , 赵晨 , 张晓雨 , 等 . 病络理论下泛血管疾病中西医结合防治理论基础及实施思路 [J]. 中国中西医结合杂志 , 2022 , 42 ( 11 ): 1392 - 1395 .
YOU L Z , ZHAO C , ZHANG X Y , et al . Theoretical basis and implementation of integrated traditional Chinese and western medicine for prevention and treatment of pan-vascular diseases under abnormal collateral theory [J]. Chin J Integr Med , 2022 , 42 ( 11 ): 1392 - 1395 .
卢健棋 , 温志浩 . 中医药干预冠脉微循环障碍的研究近况 [J]. 中国中医基础医学杂志 , 2013 , 19 ( 5 ): 597 - 600 .
LU J Q , WEN Z H . Recent research on the intervention of traditional Chinese medicine on coronary microcirculation disorder [J]. Chin J Basic Med Tradit Chin Med , 2013 , 19 ( 5 ): 597 - 600 .
徐家淳 , 覃启京 , 孙伟明 , 等 . 脑梗死后大脑微循环障碍与中医学“通络”之探讨 [J]. 辽宁中医杂志 , 2021 , 48 ( 1 ): 78 - 80 .
XU J C , XUN Q J , SUN W M , et al . Exploration on dredging collateralsin traditional Chinese medicine and brain microcirculation dysfunction after cerebral infarction [J]. Liaoning J Tradit Chin Med , 2021 , 48 ( 1 ): 78 - 80 .
陈峰 , 陈晓明 , 郭术莲 . 中医药治疗糖尿病肾脏微循环障碍临床探讨 [J]. 中国妇幼健康研究 , 2016 , 27 ( S1 ): 188 .
CHEN F , CHEN X M , GUO S L . Clinical study on the treatment of diabetic renal microcirculation disorder with traditional Chinese medicine [J]. Chin J Woman Child Health Res , 2016 , 27 ( S1 ): 188 .
石清兰 , 王明刚 , 王秀峰 , 等 . 肝衰竭肝微循环障碍与中医“瘀”证关系探讨 [J]. 辽宁中医杂志 , 2018 , 45 ( 2 ): 272 - 274 .
SHI Q L , WANG M G , WANG X F , et al . Relationship between hepatic microcirculation disorder in liver failure and "blood stasis" syndrome in traditional Chinese Medicine [J]. Liaoning J Tradit Chin Med , 2018 , 45 ( 2 ): 272 - 274 .
张琪 , 曹林忠 , 蒋玮 . 中医药改善股骨头坏死微循环障碍研究进展 [J]. 中医临床研究 , 2021 , 13 ( 18 ): 109 - 112 .
ZHANG Q , CAO L Z , JIANG W . Research progress of traditional Chinese medicine in improving microcirculation disturbance of femoral head necrosis [J] Chin Clin Res , 2021 , 13 ( 18 ): 109 - 112 .
李会敏 , 魏军平 , 韦茂英 , 等 . 基于“玄府郁闭-眼部微循环障碍”探讨甲状腺相关眼病 [J]. 中华中医药学刊 , 2023 , 41 ( 5 ): 107 - 110 .
LI H M , WEI J P , WEI M Y , et al . Discussion on thyroid-associated ophthalmopathy based on "Xuanfu obstruction- ocular microcirculation disorder "[J]. Chin Arch Tradit Chin Med , 2023 , 41 ( 5 ): 107 - 110 .
曾小粤 , 罗陆一 , 杨焕斌 , 等 . 补肾祛瘀汤治疗下肢深静脉血栓形成30例临床报告 [J]. 中国中西医结合外科杂志 , 2002 ,( 1 ): 29 - 30 .
ZENG X Y , LUO L Y , YANG H B , et al . Clinical report on 30 cases of lower extremity deep vein thrombosis treated by Bushen Quyu decoction [J]. Chin J Surg Integr Tradit West Med , 2002 ( 1 ): 29 - 30 .
王翠珍 . baPWV/ABI检测与冠心病及其中医证型之间的相关性研究分析 [D]. 沈阳 : 辽宁中医药大学 , 2009 .
WANG C Z . Study and Analysis on the correlation between bapwv/abi detection and coronary heart disease and its TCM syndrome types [D]. Shenyang : Liaoning University of Chinese Medicine , 2009 .
刘惠洁 , 张琳琪 . 养心通脉汤治疗糖尿病性下肢动脉硬化闭塞症临床研究 [J]. 世界中西医结合杂志 , 2018 , 13 ( 8 ): 1112 - 1115 .
LIU H J , ZHANG L Q . Clinical research of yangxin tongmai decoction in the treatment of diabetic atherosclerotic occlusive disease of lower limbs [J]. World J Integr Tradit West Med , 2018 , 13 ( 8 ): 1112 - 1115 .
陈胤峰 , 何庆勇 , 刘超 , 等 . 清热活血方剂干预冠心病心绞痛瘀热互结证临床观察 [J]. 中华中医药杂志 , 2017 , 32 ( 9 ): 4288 - 4291 .
CHEN Y F , HE Q Y , LIU C , et al . Clinical observation on coronary heart disease angina pectoris patients with syndrome of binding of static blood and heat intervened by Qingre Huoxue decoction [J]. China J Tradit Chin Med Pharm , 2017 , 32 ( 9 ): 4288 - 4291 .
罗文儒 . 试谈冠心病从肺论治 [J]. 辽宁中医杂志 , 1985 ( 3 ): 37 .
LUO W R . On the treatment of coronary heart disease from lung [J]. Liaoning J Tradit Chin Med , 1985 ( 3 ): 37 .
吴志方 , 罗毅文 , 王斌 , 等 . 补肾活血法预防肾虚血瘀型下肢骨折术后深静脉血栓形成的临床研究 [J]. 中国中医骨伤科杂志 , 2017 , 25 ( 9 ): 12 - 16 .
WU Z F , LUO Y W , WANG B , et al . Clinical study on prevention of postoperative deep venous thrombosis formation in kidney deficiency and blood stasis type of lower limb fracture by Bushen huoxue method [J]. Chin J Tradit Med Traumatol Orthop , 2017 , 25 ( 9 ): 12 - 16 .
付军 , 蒋燕妮 , 刘辉 , 等 . 调脾护心方治疗稳定性冠心病的疗效及对心率变异性的影响 [J]. 中西医结合心脑血管病杂志 , 2024 , 22 ( 19 ): 3483 - 3486 .
FU J , JIANG Y N , LIU H , et al . The Effect of Tiaopi Huxin formula on stable coronary heart disease and heart rate variability [J]. Chin J Integr Med Cardio -Cerebrovascuiar Dis , 2024 , 22 ( 19 ): 3483 - 3486 .
王枝梅 . 调脾通络健心汤辅治冠心病疗效观察 [J]. 实用中医药杂志 , 2024 , 40 ( 5 ): 968 - 970 .
WANG Z M . Observation on the curative effect of tiaopitongluo Jianxin decoction in the adjuvant treatment of coronary heart disease [J]. J Practical Tradit Chin Med , 2024 , 40 ( 5 ): 968 - 970 .
李爱中 , 崔向阳 . 60例肝郁气滞及其相关证候病人的甲皱微循环变化浅析 [J]. 黑龙江中医药 , 1989 , ( 5 ): 50 - 51 .
LI A Z , CUI X Y . Analysis of nail fold microcirculation changes in 60 patients with liver stagnation and Qi stagnation and related syndromes [J]. Heilongjiang J Tradit Chin Med , 1989 , ( 5 ): 50 - 51 .
张问渠 , 孙恩亭 , 谢小冰 , 等 . 高血压病肝郁证的临床研究 [J]. 中西医结合杂志 , 1987 , ( 7 ): 396 - 399,387 .
ZHANG W Q , SUN E T , XIE X B , et al . Clinical study on liver depression syndrome of hypertension [J]. J Integr Tradit Chin West Med , 1987 , ( 7 ): 396 - 399,387 .
王贤良 , 毛静远 , 王恒和 , 等 . 理气宽胸活血法治疗心脏X综合征的临床研究 [J]. 上海中医药杂志 , 2009 , 43 ( 1 ): 33 - 35 .
WANG X L , MAO J Y , WANG H H , et al . Clinical study on Qi-regulating, chest-relaxing and blood-activating therapy for cardiac syndrome X [J]. Shanghai J Tradit Chin Med , 2009 , 43 ( 1 ): 33 - 35 .
张新元 . 疏肝理气法治疗心脏X综合征48例临床体会 [J]. 中国中医急症 , 2008 ( 11 ): 1608 - 1609 .
ZHANG X Y . Clinical experience of soothing the liver and regulating Qi in the treatment of 48 cases of cardiac X syndrome [J]. J Emerg Tradit Chin Med , 2008 ( 11 ): 1608 - 1609
张广平 , 谢华宁 . 乐脉丸治疗心脏X综合征的临床观察 [J]. 中西医结合心脑血管病杂志 , 2020 , 18 ( 2 ): 301 - 302 .
ZHANG G P , XIE H N . Clinical observation of Lemai pill in the treatment of cardiac syndrome X [J]. Chin J Integr Med Cardio-Cerebrovascuiar Dis , 2020 , 18 ( 2 ): 301 - 302 .
白惠敏 , 冯灿 , 伍锋 , 等 . 丹参多酚酸盐对冠状动脉粥样硬化性心脏病的临床疗效和药理机制研究进展 [J]. 世界临床药物 , 2024 , 45 ( 4 ): 424 - 429 .
BAI H M , FENG C , WU F , et al . Research progress on clinical efficacy and pharmacological mechanism of salvianolate in treating coronary atherosclerotic heart disease [J]. World Clin Drugs , 2024 , 45 ( 4 ): 424 - 429 .
赵阳 , 郑景辉 , 徐文华 , 等 . 基于系统药理学和分子对接研究薤白治疗冠心病的作用机制 [J]. 中华中医药学刊 , 2020 , 38 ( 1 ):105-109, 272 - 274 .
ZHAO Y , ZHENG J H , XU W H , et al . Study on the mechanism of action of Xubai in the treatment of coronary heart disease based on system pharmacology and molecular docking [J]. Chin Arc Trad Chin Med , 2020 , 38 ( 1 ):105-109, 272 - 274 .
卜彦昊 , 姚淮芳 . 基于炎症免疫反应探究复方三七颗粒抗动脉粥样硬化作用机制 [J]. 中医药临床杂志 , 2023 , 35 ( 3 ): 526 - 531 .
BU Y H , YAO H F . Preliminary study on the anti-atherosclerotic inflammatory immune mechanism of Fufangsanqi-keli [J]. Clin J Tradit Chin Med , 2023 , 35 ( 3 ): 526 - 531 .
刘雅蓉 , 邵倩 , 张慧慧 , 等 . 丹皮酚上调小凹蛋白-1抑制NF- κ B通路减轻动脉粥样硬化模型大鼠主动脉血管内皮炎症的作用 [J]. 中国中药杂志 , 2020 , 45 ( 11 ): 2578 - 2585 .
LIU Y R , SHAO Q , ZHANG H H , et al . Inhibitory effect of paeonol on aortic endothelial inflammation in atherosclerotic rats by up-regulation of caveolin-1 expression and suppression of NF- κ B pathway [J]. China J Chin Mater Med , 2020 , 45 ( 11 ): 2578 - 2585 .
纪凌云 , 陈维达 , 葛春蕾 , 等 . 基于TLR4/MyD88/NF- κ B信号通路介导的巨噬细胞焦亡探讨黄芩黄连药对治疗动脉粥样硬化的作用机制 [J]. 中华中医药杂志 , 2024 , 39 ( 5 ): 2266 - 2272 .
JI L Y , CHEN W D , GE C L , et al . Mechanism of Scutellariae Radix-Coptidis Rhizoma in the treatment of atherosclerosis based on TLR4/MyD88/NF- κ B signaling pathway mediated pyrodeath of macrophages [J]. China J Tradit Chin Med Pharm , 2024 , 39 ( 5 ): 2266 - 2272 .
辛来运 , 路迎冬 , 高嘉良 , 等 . 黄芩苷防治动脉粥样硬化作用机制的研究进展 [J]. 中华中医药学刊 , 2022 , 40 ( 3 ): 77 - 83 .
XIN L Y , LU Y D , GAO J L , et al . Research progress on prevention and treatment of atherosclerosis with Baicalin [J]. Chin Arch Tradit Chin Med , 2022 , 40 ( 3 ): 77 - 83 .
唐富天 , 钱之玉 , 郑书国 . 西红花酸对高血脂家兔血管舒张功能的影响及其机制 [J]. 中国动脉硬化杂志 , 2005 ( 6 ): 721 - 724 .
TANG F T , QIAN Z Y , ZHENG S G . Effect of crocetin on relaxation function of thoracic aorta isolated from hyperlipidemic rabbit and its mechanism [J]. Chin J Arterioscl , 2005 ( 6 ): 721 - 724 .
朱晓新 , 李连达 , 刘建勋 , 等 . 牡荆素鼠李糖苷对内皮细胞血管舒缩因子表达影响的实验研究 [J]. 中国中药杂志 , 2006 , 31 ( 7 ): 566 - 569 .
ZHU X X , LI L D , LIU J X , et al . Effect of vitexia-rhamnoside(V-R) on vasomotor factors expression of endothelial cell [J]. Chin J Chin Mater Med , 2006 , 31 ( 7 ): 566 - 569 .
崔广智 , 金树梅 , 范英昌 . 丹酚酸B对人脐静脉内皮细胞株细胞血管舒缩因子的影响 [J]. 中国老年学杂志 , 2009 , 29 ( 18 ): 2346 - 2348 .
CUI G Z , JIN S M , FAN Y C . Effect of salvianolic acid B on vasomotor factors of human umbilical vein endothelial cell line [J]. Chin J Gerontol , 2009 , 29 ( 18 ): 2346 - 2348 .
戴敏 , 刘青云 , 訾晓梅 . 丹皮酚对高脂血症大鼠动脉内皮细胞的保护作用 [J]. 中国中医基础医学杂志 , 2001 , 6 ( 2 ): 38 - 40 .
DAI M , LIU Q Y , ZI X M . Protective effective of paeonol on artery endothelial cells of the hyperlipidaemia rats [J]. Chin J Basic Med Tradit Chin Med , 2001 , 6 ( 2 ): 38 - 40 .
殷惠军 , 张波 , 史大卓 , 等 . 蒺藜总皂苷对家兔动脉粥样硬化ET/NO和NOS影响的研究 [J]. 中西医结合心脑血管病杂志 , 2005 , 3 ( 9 ): 771 - 773 .
YIN H J , ZHANG B , SHI D Z , et al . Effects of gross saponins from tribulus terrestris on expression of ET/NO and NOS in atherosclerotic rabbits [J]. Chin J Integr Med Cardio -Cerebrovasc Dis , 2005 , 3 ( 9 ): 771 - 773 .
YANG B , LI H , QIAO Y , et al . Tetramethylpyrazine attenuates the endotheliotoxicity and the mitochondrial dysfunction by doxorubicin via 14-3-3 γ /Bcl-2 [J]. Oxid Med Cell Longev , 2019 , 2019 : 5820415 .
WAN Q , LIU Z , YANG Y . Puerarin inhibits vascular smooth muscle cells proliferation induced by fine particulate matter via suppressing of the p38 MAPK signaling pathway [J]. BMC Complement Altern Med , 2018 , 18 ( 1 ): 146 .
聂忠富 , 孙小燕 , 张太平 , 等 . 人参皂苷Compound K对动脉粥样硬化大鼠氧化应激、炎症因子和血管活性物质的影响 [J]. 河北中医 , 2019 , 41 ( 7 ): 1042 - 1047 .
NIE Z F , SUN X Y , ZHANG T P , et al . Effect of ginsenoside compound K on oxidative stress, inflammatory factors and vasoactive substances in atherosclerotic rats [J]. Hebei Tradit Chin Med , 2019 , 41 ( 7 ): 1042 - 1047 .
樊华 . 灯盏花中野黄芩苷对气滞血瘀型动脉粥样硬化的干预作用及机制研究 [D]. 沈阳 : 辽宁中医药大学 , 2018 .
FAN H . Study on the intervention effect and mechanism of scutellarin in Erigeron breviscapus on atherosclerosis of qi stagnation and blood stasis type [D]. Shenyang : Liaoning University of Chinese Medicine , 2018 .
赵梦涵 , 刘婷 , 范超文 , 等 . 基于Nrf2/HO-1通路探讨虎杖含药血清对血管内皮细胞铁死亡的干预作用 [J]. 中药材 , 2023 , 46 ( 11 ): 2831 - 2836 .
ZHAO M H , LIU T , FAN C , et al . Explore the intervention effect of Polygonum cuspidatum medicated serum on iron death of vascular endothelial cells based on Nrf2/HO-1 pathway [J]. Chin Med Mat , 2023 , 46 ( 11 ): 2831 - 2836
范增光 , 袁野 . 苏木提取物对动脉粥样硬化模型ApoE -/- 小鼠氧化应激作用及对p38/JNK/ERK的影响 [J]. 江西中医药大学学报 , 2022 , 34 ( 4 ): 89 - 94 .
FAN Z G , YUAN Y . The Effect of sappanwood ethyl acetate extract on oxidative stress in ApoE -/- mice model of atherosclerosis and on p38/JNK/ERK [J]. J Jiangxi Univ Tradit Chin Med , 2022 , 34 ( 4 ): 89 - 94 .
胡哲 , 赵军 , 宋嵬 , 等 . 银杏叶提取物对脑缺血再灌注损伤模型大鼠的脑保护作用 [J]. 中国比较医学杂志 , 2022 , 32 ( 9 ): 55 - 61 .
HU Z , ZHAO J , SOGN W , et al . Protective effect of Ginkgo biloba extract on the brain in a cerebral ischemia-reperfusion injury rat model [J]. Chin J Comp Med , 2022 , 32 ( 9 ): 55 - 61 .
刘湘 , 乔丽菲 , 刘垚君 , 等 . 芍药苷对脑缺血再灌注损伤大鼠 NLRP3 炎症体信号通路相关因子表达的影响 [J]. 中国中医药信息杂志 , 2019 , 26 ( 10 ): 40 - 44 .
LIU X , QIAO L F , LIU Y J , et al . Effects of paeoniflorin on expression of factors of NLRP3 inflammatory signaling pathwayin cerebral ischemic-reperfusion injury rats [J]. Chin J Inf Tradit Chin Med , 2019 , 26 ( 10 ): 40 - 44 .
夏霜莉 , 王维 , 张冰琳 , 等 . 天麻总酚抗大鼠脑缺血再灌注损伤的转录组学分析及实验验证 [J]. 中草药 , 2021 , 52 ( 5 ): 1402 - 1410 .
XIA S L , WANG W , ZHANG B L , et al . Analysis on transcriptomic characteristics of total phenols of Gastrodia elata in prevention of CIRI based on RNA-seq technology [J]. Chin Tradit Herb Drug , 2021 , 52 ( 5 ): 1402 - 1410 .
喻志慧 , 黎良达 . 川芎嗪对小鼠脑缺血再灌注损伤的影响 [J]. 中国临床药理学杂志 , 2020 , 36 ( 12 ): 1648 - 1652 .
YU Z H , LI L D . Effect of ligustrazine on the cerebral ischemia-reperfusion injury in mice [J]. Chin J Clin Pharmacol , 2020 , 36 ( 12 ): 1648 - 1652 .
刘洋 , 李嘉民 , 陈荣 , 等 . 白藜芦醇苷对脑缺血再灌注损伤小鼠血脑屏障的保护作用研究 [J]. 天津医科大学学报 , 2022 , 28 ( 3 ): 278 - 283 .
LIU Y , LI J M , CHEN R , et al . Protective effect of polydatin on blood-brain barrier in mice after transient focal cerebral ischemia [J]. J Tianjin Med Univ , 2022 , 28 ( 3 ): 278 - 283 .
SHEN H P , PEI H Y , ZHAI L P , et al . Salvianolic acid C improves cerebral ischemia reperfusion injury through suppressing microglial cell M1 polarization and promoting cerebral angiogenesis [J]. Int Immunopharmacol , 2022 , 110 : 109021 .
SU L J , REN Y C , CHEN Z , et al . Ginsenoside Rb l improves brain, lung, and intestinal barrier danage in middle cerebral artery occlusion/reperfusion (MCAO/R) micevia the PPARy signaling pathway [J]. Chin J Nat Med , 2022 , 20 ( 8 ): 561 - 571 .
ZHANG S X , CHEN Q Y , JIN M Q , et al . Notoginsenoside R 1 alleviates cerebral ischemia/reperfusion injury by inhibiting the TLR4/MyD88/NF- κ B signaling pathway through microbiota-gut-brain axis [J]. Phytomed , 2024 , 128 : 155530 .
GUAN Y , CAO Y L , LIU J W , et al . Ginsenoside Rg l attenuates cerebral ischemia-reperfusion injury through inhibiting the inflammatory activation of microglia [J]. Exp Cell Res , 2023 , 426 ( 1 ): 113552 .
GAO J L , YAO M J , ZHANG Y H , et al . Panax notoginseng saponins stimulates the differentiation and neurite development of C17.2 neural stem cells against OGD/R injuries via mTOR signaling [J]. Biomed Pharmacother , 2024 , 172 : 116260 .
刘瑶 . 黄芪-丹参药对活性成分在高血压肾损害中调控microRNA-200c-3p保护肾动脉内皮机制研究 [D]. 济南 : 山东中医药大学 , 2020 .
LIU Y . The mechanisms of the active ingredi .ents of Astragalus membranaceus and Salvia miltiorrhizae herb pair protectingrenal artery endothelium via regulating microRNA-200c-3p in hypertensiverenal damage[D]. Jinan : Shandong University of Traditional Chinese Medicine , 2020 .
包自阳 , 廖建 , 李先法 , 等 . 雷公藤内酯醇抑制肾缺血再灌注大鼠肾小管上皮细胞凋亡的机制研究 [J]. 中国现代应用药学 , 2018 , 35 ( 7 ): 1041 - 1045 .
BAO Z Y , LIAO J , LI X F , et al . Mechanism of triptolide inhibits renal tubular epithelial cell apoptosis in renal ischemia reperfusion rat [J]. Chin J Mod Applied Pharm , 2018 , 35 ( 7 ): 1041 - 1045 .
李莉 , 杨敏 , 何华琼 , 等 . 冬虫夏草菌粉对肾缺血-再灌注损伤大鼠Klotho基因和免疫调节的影响 [J]. 中国中医急症 , 2016 , 25 ( 7 ): 1290 - 1292,1311 .
LI L , YANG M , HE H Q , et al . Effect of cordyceps sinensis on rat Klotho gene and immune regulation of renal ischemia-reperfusion injury [J]. J Emerg Tradit Chin Med , 2016 , 25 ( 7 ): 1290 - 1292,1311 .
尚孟秋 , 梁丽娜 , 周维 , 等 . 基于数据挖掘探讨中医药治疗视网膜静脉阻塞黄斑水肿的组方规律 [J]. 中国中医眼科杂志 , 2024 , 34 ( 10 ): 922 - 928 .
SHANG M Q , LIANG L N , ZHOU W , et al . Exploring the prescription patterns of traditional Chinese medicine in the treatment of retinal vein occlusion with macular edema based on data mining [J]. Chin J Ophthalmol , 2024 , 34 ( 10 ): 922 - 928 .
晏豆豆 , 念兴涛 , 李偲 , 等 . 基于数据挖掘的中医药治疗精索静脉曲张用药规律分析 [J]. 基层中医药 , 2024 , 3 ( 9 ): 104 - 111 .
YAN D D , NIAN X T , LI S , et al . Medication rules of traditional Chinese medicine in the treatment of varicocele based on data mining [J]. Basic Tradit Chin Med , 2024 , 3 ( 9 ): 104 - 111 .
朱洋文 , 王刚 , 李小堃 . 髂静脉压迫综合征的中西医治疗进展 [J]. 血管与腔内血管外科杂志 , 2024 , 10 ( 9 ): 1109 - 1113 .
ZHU Y W , WANG G , LI X K . Research progress of iliac vein compression syndrome in traditional Chinese and western medicine [J]. J Vascul End Surg , 2024 , 10 ( 9 ): 1109 - 1113 .
纪秋如 , 泥文娟 , 王晓艳 , 等 . 基于人脐静脉内皮细胞的OGD/R模型研究当归-川芎药对中7个活性成分对VEGF-PI3K-Akt/NF- κ B信号通路的影响 [J]. 世界科学技术—中医药现代化 , 2024 , 26 ( 3 ): 691 - 703 .
JI Q R , NI W J , WANG X Y , et al . HUVEC-Based OGD/R injury model to study the effect of Danggui-Chuanxiong Herb pair medicine on the main pharmacological components on VEGF-PI3K-AKT/NF- κ B signaling pathway [J]. World Sci Technol - Mod Tradit Chin Med , 2024 , 26 ( 3 ): 691 - 703 .
汪云凤 . 内补黄芪汤加味治疗下肢静脉性溃疡(气虚血瘀证)的临床观察 [D]. 哈尔滨 : 黑龙江中医药大学 , 2024 .
WANG Y F . Clinical observation of supplementing Neibuhuangqi decoction in treating venous leg ulcer(Qi deficiency and blood stasis syndrome) [D]. Harbin : Heilongjiang University of Chinese Medicine , 2024 .
刘凤 , 刘增长 . 茯苓酸通过激活Nrf2/HO-1信号通路改善OX-LDL诱导的人脐静脉内皮细胞损伤 [J]. 中国免疫学杂志 , 2020 , 36 ( 2 ): 164 - 168,179 .
LIU F , LIU Z Z . Pachymic acid inhibits OX-LDL-induced injury in human umbilical vein endothelial cells via activating Nrf2/HO-1 signaling pathway [J]. Cell Mol Immunol , 2020 , 36 ( 2 ): 164 - 168,179 .
刘文频 , 熊向晖 , 宾晓芳 , 等 . 黄芪甲苷通过上调miR-1226缓解ox-LDL诱导人脐静脉血管内皮细胞损伤 [J]. 中药材 , 2024 , doi: 10.13863/j.issn1001-4454.2024.08.030 http://dx.doi.org/10.13863/j.issn1001-4454.2024.08.030 .
LIU W P , XIOGN X H , BIN X F , et al . Effects of astragaloside Ⅳ on ox-LDL-induced endothelial cell injuryin human umbilical vein by upregulating miR-1226 [J]. Chin Med Mat , 2024 , doi: 10.13863/j.issn1001-4454.2024.08.030 http://dx.doi.org/10.13863/j.issn1001-4454.2024.08.030 .
ZHANG Y , MA X J , GUO C Y , et al . Pretreatment with a combination of ligustrazine and berberine improves cardiac function in rats with coronary microembolization [J]. Acta Pharmacol Sin , 2016 , 37 ( 4 ): 463 - 472 .
马学宽 , 古丽葛娜·萨吾尔 , 张亚洁 , 等 . 天香丹对冠状动脉微循环障碍模型大鼠心肌组织Nrf2/ARE信号通路的影响 [J]. 中医杂志 , 2021 , 62 ( 3 ): 246 - 251 .
MA X K , GULIGENA S , ZHANG Y J , et al . The effect of Tian Xiang Dan on Nrf2/ARE signaling pathway in myocardial tissues of model rats with coronary microcirculation dysfunction [J]. J Tradit Chin Med , 2021 , 62 ( 3 ): 246 - 251 .
张乃广 , 刘全炯 , 林爱华 . 替格瑞洛联合血府逐瘀胶囊对ST段抬高型心肌梗死PCI术后心肌微循环及不良心血管事件的影响 [J]. 黑龙江医学 , 2024 , 48 ( 18 ): 2224 - 2226 .
ZHANG N G , LIU Q J , LIN A H . Effects of ticagrelor combined with Xuefu Zhuyu capsule on myocardial microcirculation and adverse cardiovascular events after PCI for ST segment elevation myocardial infarction [J]. Heilongjiang Med J , 2024 , 48 ( 18 ): 2224 - 2226 .
郝馨卉 , 韩暄 . 水蛭及其提取物在糖尿病微血管病变中的应用及研究进展 [J]. 中国当代医药 , 2024 , 31 ( 18 ): 186 - 189 .
HAO X H , HAN X . Application and research progress of leech and its extracts in diabetic microangiopathy [J]. China Mod Med , 2024 , 31 ( 18 ): 186 - 189 .
陈瑶 , 王胜娟 , 李朝玲 , 等 . 丹参对于急性微循环障碍大鼠血管内皮细胞的保护作用 [J]. 陕西中医 , 2016 , 37 ( 4 ): 506 - 508 .
CHEN Y , WAGN S J , LI C L , et al . The protective effect of Salvia miltiorrhiza on the acute microcirculation disturbance mice vascular endothelial cells [J]. Shaanxi J Tradit Chin Med , 2016 , 37 ( 4 ): 506 - 508 .
兰涛 , 陈辉 , 孙清森 , 等 . 桃仁提取物对重症急性胰腺炎大鼠微循环障碍的影响及其作用机制研究 [J]. 中药材 , 2015 , 38 ( 2 ): 354 - 357 .
LAN T , CHEN H , SUN Q S , et al . Study on the effect and mechanism of peach kernel extract on microcirculatory disorders in rats with severe acute pancreatitis [J]. J Chin Med Mater , 2015 , 38 ( 2 ): 354 - 357 .
彭英克 , 赵莉 . 五苓散加味治疗美尼埃病临床观察 [J]. 中国民间疗法 , 2012 , 20 ( 8 ): 36 .
PENG Y K , ZHAO L . Clinical observation on modified Wuling powder in the treatment of Meniere's disease [J]. China's Naturop , 2012 , 20 ( 8 ): 36 .
黄国恩 . 柴胡桂枝干姜汤合五苓散治疗肝硬化腹腔积液的临床研究 [J]. 实用医技杂志 , 2017 , 24 ( 12 ): 1383 - 1384 .
HUANG G E . Clinical study on Chaihu Guizhi Ganjiang decoction combined with Wuling powder in the treatment of liver cirrhosis with ascites [J]. J Pract Med Tech , 2017 , 24 ( 12 ): 1383 - 1384 .
周茂琳 , 王怿 , 周嫦 , 等 . 中医药对淋巴管新生与回流功能的作用研究进展 [J]. 世界科学技术—中医药现代化 , 2022 , 24 ( 2 ): 802 - 809 .
ZHOU M L , WANG Y , ZHOU C , et al . A Research progress of traditional Chinese medicine acting on the lymphangiogenesis and lymphatic drainage function [J]. World Sci Technol - Mod Tradit Chin Med , 2022 , 24 ( 2 ): 802 - 809 .
LIN Q Y , ZHANG Y L , BAI J , et al . VEGF-C/VEGFR-3 axis protects against pressure-overload induced cardiac dysfunction through regulation of lymphangiogenesis [J]. Clin Transl Med , 2021 , 11 ( 3 ): e374 .
鲍嘉敏 , 徐浩 , 杭明辉 , 等 . 人参皂苷Re对淋巴管内皮细胞VEGF-C表达及其功能的影响 [J]. 中华中医药杂志 , 2022 , 37 ( 12 ): 7018 - 7022 .
BAO J M , XU H , HANG M H , et al . Effects of ginsenoside Re on the expression of VEGF-C and function in lymphatic endothelial cells [J]. China J Tradit Chin Med Pharm , 2022 , 37 ( 12 ): 7018 - 7022 .
陈君媚 . 当归芍药散改善脑膜淋巴管引流脑淋巴功能治疗sAD神经炎症小鼠认知障碍机制研究 [D]. 广州 : 广州中医药大学 , 2023 .
CHEN J M . Danggui Shaoyao powder improves meningeal lymphatic drainage and brain lymphatic function in the treatment of cognitive impairment in sad neuroinflammatory mice [D]. Guangzhou : Guangzhou University of Chinese Medicine , 2023 .
郑扬康 , 王鹏禹 , 赵力 , 等 . 身痛逐瘀汤疏通淋巴管瘀滞促进骨修复的实验研究 [J]. 中国骨质疏松杂志 , 2022 , 28 ( 11 ): 1599 - 1603 .
ZHENG Y K , WANG P Y , ZHAO L , et al . Experimental study on the promotion of bone repair by Shentong Zhuyu decoction in dredging lymphatic stasis [J]. Chin J Osteoporos , 2022 , 28 ( 11 ): 1599 - 1603 .
王博文 . 防己茯苓汤加味治疗下肢淋巴水肿的临床研究 [D]. 济南 : 山东中医药大学 , 2022 .
WANG B W . Clinical research in the treatment of lower extremity lymphedema by modified Tetrandra and Poria decoction [D]. Jinan : Shandong University of Traditional Chinese Medicine , 2022 .
李洪峥 , 王阶 , 何浩强 , 等 . 基于中医思维的冠心病心绞痛病证结合诊疗知识模型构建 [J]. 中医杂志 , 2019 , 60 ( 15 ): 1288 - 1293 .
LI H Z , WANG J , HE H Q , et al . Construction of diagnosis-treatment knowledge model of diseases and syndrome combination for coronary heart disease angina pectoris: Based on traditional Chinese medicine thinking [J]. J Tradit Chin Med , 2019 , 60 ( 15 ): 1288 - 1293 .
王阶 , 姚魁武 , 王永霞 , 等 . 血瘀证量化诊断及病证结合研究 [J]. 中西医结合学报 , 2003 ( 1 ): 21 - 24 .
WANG J , YAO K W , WANG Y X , et al . Research on quantified diagnosis and combining diseases with syndrome of blood stasis [J]. J Integr Med , 2003 ( 1 ): 21 - 24 .
WANG J , DUAN L , LI H , et al . Construction of an artificial intelligence traditional Chinese medicine diagnosis and treatment model based on syndrome elements and small-sample data [J]. Engineering , 2022 , 8 : 29 - 32 .
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