Neurotensin and ACTH are neuropeptids as endogenous cryogensin central nervous system

BOdy temperature was rapidly decreased when[D Tyr"] neurotensin（NT） or ACTH was administered in cerebroventricular injec-tion（icv）in normal rats.The hypothermic action of NT was dose一dependentpattern and related to environmentaI temperature. Oral administration of 10gcrude drug/Kg Guizhi decoction（GZD）one hour before icv of NT could an-tagonize the hypothermia. But this antagonistic effect was not observed in the ex-periment with ACTH treatment.The results indicated that NT was involved inthe mechanism of dual directional thermoregulation by GZD

but the role ofACTH in the thermoregulation was unclear.