The Mechanism of Dual-Directional Thermoregulation by“Guizhi Tang”(桂枝汤Decoction of CinnamonTwigs)---Effect on the Action of Acetylcholine and Norepinephrine in Hypothalamus

Fu Hangyu; Guo Shuying; Gao Yingjie; Zhou Aixiang; Tian Jiali

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The Mechanism of Dual-Directional Thermoregulation by“Guizhi Tang”(桂枝汤Decoction of CinnamonTwigs)---Effect on the Action of Acetylcholine and Norepinephrine in Hypothalamus

更新时间：2024-01-04

- The Mechanism of Dual-Directional Thermoregulation by“Guizhi Tang”(桂枝汤Decoction of CinnamonTwigs)---Effect on the Action of Acetylcholine and Norepinephrine in Hypothalamus
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 2, Issue 2, Pages: 8-10(1996)
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  CLC： R285
- Published：1996
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Fu Hangyu, Guo Shuying, Gao Yingjie, et al. The Mechanism of Dual-Directional Thermoregulation by“Guizhi Tang”(桂枝汤Decoction of CinnamonTwigs)---Effect on the Action of Acetylcholine and Norepinephrine in Hypothalamus[J]. Chinese journal of experimental traditional medical formulae, 1996, 2(2): 8-10.
DOI：

Fu Hangyu, Guo Shuying, Gao Yingjie, et al. The Mechanism of Dual-Directional Thermoregulation by“Guizhi Tang”(桂枝汤Decoction of CinnamonTwigs)---Effect on the Action of Acetylcholine and Norepinephrine in Hypothalamus[J]. Chinese journal of experimental traditional medical formulae, 1996, 2(2): 8-10. DOI：

摘要

大鼠脑室注射去甲肾上腺素20ng/只

能快速引起体温下降;口饲给予10g/kg桂枝汤

能部分拮抗去甲肾上腺素的降温作用。大鼠脑室注射乙酰胆碱1mg/只

能使体温升高;口饲给予桂枝汤

能阻断其发热反应。结果提示

桂枝汤可能通过促进下丘脑中过量去甲肾上腺素或乙酰胆碱的灭活

拮抗或部分拮抗它们的降体温或发热作用。

Abstract

After 20ng norepinephrine administered intracerebroventriculary(icv)

the body temperature of rats was rapidly dropped and 15 minutes later

minmized and the value of the area under the body temperature-time curve in 0.67 hours(TRI0.67)was -0.92±0.26. The hypothermic action of norepinephrine was inhibited by 10g/kg Guizhi Tang per os

with TRI0.67) being -0.50±0.10(P＜0.01).1mg of Acetycholine icv was observed to cause hyperthermia.The peak was reached in 2 hours

and TRI3.0 was 1.25±0.52. Guizhi Tang p.o.could

on the other hand

bolck hyperthermia reaction induced by acetylcholine and the TRI3.0) was 0.34±0.49(P＜0.01).The evidence indicated that Guizhi Tang could promoted degradation of excessive norepinephrine or acetycholibne in hypothalamus.

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