Effecf of Liuwei Dihuang Decoction(LWDH) on the Expression of P53 Gene in Lung Adenomas Induced in Mice
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Effecf of Liuwei Dihuang Decoction(LWDH) on the Expression of P53 Gene in Lung Adenomas Induced in Mice
Chinese Journal of Experimental Traditional Medical FormulaeVol. 3, Issue 3, Pages: 17-19(1997)
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CLC:R-332
Published:1997
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Li Hui, Jin Yahong, Jiang Tingliang. Effecf of Liuwei Dihuang Decoction(LWDH) on the Expression of P53 Gene in Lung Adenomas Induced in Mice[J]. Chinese journal of experimental traditional medical formulae, 1997, 3(3): 17-19.
DOI:
Li Hui, Jin Yahong, Jiang Tingliang. Effecf of Liuwei Dihuang Decoction(LWDH) on the Expression of P53 Gene in Lung Adenomas Induced in Mice[J]. Chinese journal of experimental traditional medical formulae, 1997, 3(3): 17-19.DOI:
Effecf of Liuwei Dihuang Decoction(LWDH) on the Expression of P53 Gene in Lung Adenomas Induced in Mice
Liuwei Dihuang Decoction(LWDH)was found to decrease the incidences of lung adenoma in duced by urethan in mice.The effect of LWDH appeared more significant in the mice wirh Yin-deficiency in duced by thyroxine(T3).As compared with healthy mice as a control
the expression of tnmor suppressor gene P53 mRNA in the lungs with adenomas was onticeably reduced
which could be reversed by treatment of LWDH.The same effect of LWDH had been found in Yin-deficiency mice.