Effect and Mechanism of Active Fraction A of Guizhi Decoction（桂枝汤）on Dual-Directional Thermoregulation——Effect on IPand CaM in Hypothalamus of Rats

Huo Hairu; Tan Yuqing; Li Xiaoqin; Guo Shuying; Zhou Aixiang; Tian Jiali; Sun Yuru; He Yuzhou; Jiang Tingliang

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Effect and Mechanism of Active Fraction A of Guizhi Decoction（桂枝汤）on Dual-Directional Thermoregulation——Effect on IPand CaM in Hypothalamus of Rats

更新时间：2024-01-04

- Effect and Mechanism of Active Fraction A of Guizhi Decoction（桂枝汤）on Dual-Directional Thermoregulation——Effect on IPand CaM in Hypothalamus of Rats
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 4, Issue 2, Pages: 25-28(1998)
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  CLC： R285.5
- Published：1998
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Huo Hairu, Tan Yuqing, Li Xiaoqin, et al. Effect and Mechanism of Active Fraction A of Guizhi Decoction（桂枝汤）on Dual-Directional Thermoregulation——Effect on IPand CaM in Hypothalamus of Rats[J]. Chinese journal of experimental traditional medical formulae, 1998, 4(2): 25-28.
DOI：

Huo Hairu, Tan Yuqing, Li Xiaoqin, et al. Effect and Mechanism of Active Fraction A of Guizhi Decoction（桂枝汤）on Dual-Directional Thermoregulation——Effect on IPand CaM in Hypothalamus of Rats[J]. Chinese journal of experimental traditional medical formulae, 1998, 4(2): 25-28. DOI：

摘要

桂枝汤有效部位A(Fr.A)对酵母致热大鼠下丘脑三磷酸肌醇(IP3)和钙调蛋白(CaM)的降低及安痛定诱致低体温大鼠下丘脑IP3和CaM含量的升高均有明显的逆转效应

即使高体温大鼠下丘脑IP3和CaM升高

低体温大鼠IP3和CaM降低

分别使之趋向正常。结果提示

Fr.A对体温的双向调节有中枢神经细胞内信息传递系统IP3和CaM参予。

Abstract

Effect of Fr.A

active fractive A isolated from Guizhi decoction

on inositol 1

5 triphosphate (IP3) and calmodulin (CaM) in hypothalamus in yeast-inducted febrile rats and aminopyrine-induced hypothermal rats was studied. The results showed that IP3 and CaM contents were significantly decreased in febrile rats

and markedly increased in hypothermal rats. Theose values were reversed to almost normal level in both models after administration of Fr.A. The results suggest that IP3 and CaM in the thermoregulatory center take part in the dual-directional regulation of Fr.A.

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