Effect of Jiangfang Baoxin Decoction on Renin Angiotensin System in Renovascular Hypertensive Rats

Lu Shu; Yang Di; Weng Xiaosheng; Gong Jinxing; Xu Hong; Zhang Jinan

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Effect of Jiangfang Baoxin Decoction on Renin Angiotensin System in Renovascular Hypertensive Rats

更新时间：2024-01-04

- Effect of Jiangfang Baoxin Decoction on Renin Angiotensin System in Renovascular Hypertensive Rats
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 5, Issue 3, Pages: 26-30(1999)
- 作者机构：
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- DOI：
  CLC： R285.5
- Published：1999
- 稿件说明：
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Lu Shu, Yang Di, Weng Xiaosheng, et al. Effect of Jiangfang Baoxin Decoction on Renin Angiotensin System in Renovascular Hypertensive Rats[J]. Chinese journal of experimental traditional medical formulae, 1999, 5(3): 26-30.
DOI：

Lu Shu, Yang Di, Weng Xiaosheng, et al. Effect of Jiangfang Baoxin Decoction on Renin Angiotensin System in Renovascular Hypertensive Rats[J]. Chinese journal of experimental traditional medical formulae, 1999, 5(3): 26-30. DOI：

摘要

降防保心中药复方(JF)能降低肾血管性高血压大鼠(RHR)的血压

使增高的RHR的左室重/体重比得以回降?RHR左室心肌中血管紧张素Ⅱ(AngⅡ)水平显著降低;血管紧张素转换酶(ACE)活力在肺组织中显著下降

在左室心肌及血清中ACE亦呈下降趋势。

Abstract

The study has investigated the effects of Jiangfang Baoxin decoction (JF) on blood pressure(BP)

left ventricular hypertrophy(LVH)

and renin angiotensin system(RAS) of circulation and left ventricule in renovascular hypertensive rats(RHR).The results indicated that JF can reduce BP of RHR

and decrease the enhanced left ventricular wet weight to body weight ratio of RHR.The level of angiotensin Ⅱ(AngⅡ)was decreased significantly in left ventricule of RHR treated with JF for 10 weeks.Angiotensin converting enzyme(ACE) activity was also reduced in lung.The trend of ACE was decreased in left ventricule and serum

but no significance was observed.

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