Objective: To establish a method for determination of geniposide in mice plasma by high performance liquid chromatography (HPLC)

and study the effect of borneol on the pharmacokinetics of geniposide in mice with the proposed method. Method: Mice were divided into two groups and administrated with the extraction of Gardenia jasminoides and the extraction coupled with Borneol

respectively. HPLC was used for the determination of geniposide in plasma

and the pharmacokinetic parameters were calculated by the software of Kinetica. Result: The good linearity range of geniposide in plasma was 1.187 5-76 mg ·L-1 (r=0.999 3

n=5). The pharmacokinetics model of geniposide in the two groups followed the non-compartment model. Compared with the group administrated with gardenia

the gardenia-borneol group showed significant increase in the area under the plasma concentration-time curve (AUC) and in the peak concentration (Cmax)

with an extension of the mean residence time (MRT). Conclusion: Borneol could accelerate the absorption of geniposide

decelerate its clearance speed

increase its bioavailability.