Changes in Relationship between Alkaloids Content and Time in Processing Process of Aconiti Radix Cocta

TU Yao-sheng; QUAN Zhi-hui; SUN Dong-mei; ZHANG Jian-jun; ZHAO Zi-ming

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Changes in Relationship between Alkaloids Content and Time in Processing Process of Aconiti Radix Cocta

更新时间：2024-01-04

- Changes in Relationship between Alkaloids Content and Time in Processing Process of Aconiti Radix Cocta
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 19, Issue 6, Pages: 25-29(2013)
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- Published：2013
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TU Yao-sheng, QUAN Zhi-hui, SUN Dong-mei, et al. Changes in Relationship between Alkaloids Content and Time in Processing Process of Aconiti Radix Cocta[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(6): 25-29.
DOI：

TU Yao-sheng, QUAN Zhi-hui, SUN Dong-mei, et al. Changes in Relationship between Alkaloids Content and Time in Processing Process of Aconiti Radix Cocta[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(6): 25-29. DOI：

摘要

目的: 建立川乌炮制过程中生物碱类成分的时间含量变化关系方程。方法: 采用加压蒸制法制备制川乌样品

通过HPLC测定各样品中6种生物碱类成分的含量

并对其含量-时间变化趋势进行曲线拟合

推算最佳炮制时间。结果: 川乌在111 ℃(0.05 MPa)下炮制15～150 min

制川乌中单酯型生物碱类成分时量变化关系曲线拟合回归方程为C=0.273+0.236×lnt(R2=0.753

F=48.818

P<0.01)

双酯型生物碱类成分则为C=0.115×t-0.005(R2=0.850

F=90.660

P<0.01)。结论: 建立的方法为快速炮制川乌及预测川乌炮制时间提供了有力的理论支撑。

Abstract

Objective: To establish variation relationship equation between alkaloids content and time in processing process of Aconiti Radix. Method: Aconiti Radix Cocta samples were prepared by pressurized steaming method

the content of six kinds of alkaloids in each sample was determined by HPLC

and optimum processing time was estimated by curve fitting of their content-time trend. Result: After Aconiti Radix was processed 15-150 min at 111 ℃(0.05 MPa)

fitting regression equation of variation relationship curve between diester alkaloids content in Aconiti Radix Cocta with processing time was C=0.273+0.236×lnt(R2=0.753

F=48.818

P<0.01)

monoester alkaloids was C=0.115×t-0.005(R2=0.850

F=90.660

P<0.01). Conclusion: This established method provided a theoretical support about fast processing Aconiti Radix and estimating processing time of Aconiti Radix.

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Related Institution

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