Preparation and Dissolution Investigation of Brucea javanica Oil Self-microemulsion

JIANG Nan1; LI Ye2; CHEN Gang3; SHAO A-li3; SUN Wen1; LI Tong-hui2; XIN Yong-jie2; LI Dan1

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Preparation and Dissolution Investigation of Brucea javanica Oil Self-microemulsion

更新时间：2024-09-23

- Preparation and Dissolution Investigation of Brucea javanica Oil Self-microemulsion
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 19, Issue 9, Pages: 45-48(2013)
- 作者机构：
  
  1. 陕西中医学院
  2. 陕西省中医药研究院
  3. 广东药学院
- 作者简介：
- 基金信息：
- DOI：
  CLC： R283;TQ461
- Published：2013
- 稿件说明：
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[1]蒋楠,李晔,陈钢,邵阿丽,孙雯,李彤晖,辛永洁,李丹.鸦胆子油自微乳的制备及溶出度考察[J].中国实验方剂学杂志,2013,19(09):45-48.

JIANG Nan1, LI Ye2, CHEN Gang3, et al. Preparation and Dissolution Investigation of Brucea javanica Oil Self-microemulsion[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(9): 45-48.
[1]蒋楠,李晔,陈钢,邵阿丽,孙雯,李彤晖,辛永洁,李丹.鸦胆子油自微乳的制备及溶出度考察[J].中国实验方剂学杂志,2013,19(09):45-48. DOI：

JIANG Nan1, LI Ye2, CHEN Gang3, et al. Preparation and Dissolution Investigation of Brucea javanica Oil Self-microemulsion[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(9): 45-48. DOI：

摘要

目的:制备鸦胆子油自微乳

并考察其溶出度。方法:通过溶解度试验、气相色谱法筛选辅料

伪三元相图优化自微乳处方

并进行药物溶出度试验。结果:鸦胆子油自微乳最优处方为鸦胆子油-辛酸癸酸三甘油酯-聚氧乙烯氢化蓖麻油-聚乙二醇400 12∶12∶65∶11

乳滴粒径<50 nm

15～20 min可基本完全溶出。结论:鸦胆子油自微乳稳定性良好

提高了用药的顺应性

且制备工艺简单。

Abstract

Objective:To prepare Brucea javanica oil self-microemulsion

and investigate its dissolution.Method: Solubility test and gas chromatography were used to select adjuvants

pseudo-ternary phase diagram was used to optmize prescription of the self-microemulsion

and dissolution test of the self-microemulsion was adopted.Result: Optimum prescription of B.javanica oil self-microemulsion was B.javanica oil-caprylic capric triglyceride-polyoxyethylene hydrogenated castor oil-polyethylene glycol 400 12%∶ 12%∶ 65%∶ 11%

particle size of it was<50 nm and it could be completely dissolved in 15-20 minutes.Conclusion: B.javanica oil self-microemulsion had good stability

it improved medication compliance

and this preparation technology was simple and stable.

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Related Author

JIANG Nan

LI Ye

CHEN Gang

SHAO A-li

SUN Wen

LI Tong-hui

XIN Yong-jie

LI Dan

Related Institution

Dept.of Pharmacy,General Hospital Group Oilfield Hospital of Daqing

Nanjing Medical University

Yancheng Health Vocational Technical College

Yancheng Institute for Drug Control of Jiangsu Province

School of Chinese Materia Medica,Beijing University of Chinese Medicine

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