Solubilization of Dihydromyricetin by Hydroxpropyl-β-cyclodextrin

BAI Xiu-xiu1; XIA Guang-ping2; ZHAO Na-xia2; DONG Hong-ling1; SHAO Ze-yan1; HAN Ying-mei2

您当前的位置：

首页 >

文章列表页 >

Solubilization of Dihydromyricetin by Hydroxpropyl-β-cyclodextrin

更新时间：2024-09-23

- Solubilization of Dihydromyricetin by Hydroxpropyl-β-cyclodextrin
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 19, Issue 9, Pages: 12-14(2013)
- 作者机构：
  
  1. 天津中医药大学
  2. 天津药物研究院天津市新药设计与发现重点实验室
- 作者简介：
- 基金信息：
- DOI：
  CLC： R283.6
- Published：2013
- 稿件说明：
移动端阅览
[1]白秀秀,夏广萍,赵娜夏,董虹玲,邵泽艳,韩英梅.羟丙基-β-环糊精对二氢杨梅素的增溶作用[J].中国实验方剂学杂志,2013,19(09):12-14.

BAI Xiu-xiu1, XIA Guang-ping2, ZHAO Na-xia2, et al. Solubilization of Dihydromyricetin by Hydroxpropyl-β-cyclodextrin[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(9): 12-14.
[1]白秀秀,夏广萍,赵娜夏,董虹玲,邵泽艳,韩英梅.羟丙基-β-环糊精对二氢杨梅素的增溶作用[J].中国实验方剂学杂志,2013,19(09):12-14. DOI：

BAI Xiu-xiu1, XIA Guang-ping2, ZHAO Na-xia2, et al. Solubilization of Dihydromyricetin by Hydroxpropyl-β-cyclodextrin[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(9): 12-14. DOI：

摘要

目的:研究羟丙基-β-环糊精对二氢杨梅素（DMY）的增溶作用。方法:采用相溶解度法研究不同温度下羟丙基-β-环糊精对二氢杨梅素的包合作用

HPLC测定二氢杨梅素含量。结果:溶液中DMY与HP-β-CD质量浓度呈线性相关

相溶解度曲线呈AL型

包合物中DMY与HP-β-CD物质的量比1∶1

于25

45℃下表观稳定常数分别为500.0

944.8

2 449.8mol.L-1。结论:HP-β-CD对DMY有较好的增溶作用。

Abstract

Objective:To study on solubilization of dihydromyricetin（DMY） by hydroxpropyl-β-cyclodextrin（HP-β-CD）.Method:Inclusion of HP-β-CD on DMY under different temperatures was investigated by phase-solubility method.The content of DMY was determined by HPLC.Result:With increasing of HP-β-CD in aqueous solution

solubility of DMY increased linearly

which showed typical AL-type phase solubility diagram.The molar ratio of DMY and HP-β-CD in the inclusion complex was 1∶ 1.The apparent stability constants of inclusion reaction at 25

45 ℃ were determined as 500.0

944.8

2 449.8 mol · L-1

respectively.Conclusion:The solubility of DMY was improved remarkably by HP-β-CD inclusion.

关键词

Keywords

references

Views

234

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Solubilization of Dihydromyricetin by Hydroxpropyl--cyclodextrin

Preparation Technique of Paeonol HP-β-CD Inclusion Complex with Orthogonal Design

Study on Stability and Solubilization of Oil Hydroxypropyl--cyclodextrin Inclusion Complex

Optimization of Extraction Technology for Dihydromyricetin from by Response Surface Analysis Methodology

Investigation of Dissolution of Ligustrazine Hydrochloride Cucurbituril Inclusion Compound

Related Author

HAN Ying-mei

SHAO Ze-yan

DONG Hong-ling

ZHAO Na-xia

XIA Guang-ping

BAI Xiu-xiu

LUO Xiao-jian1

Related Institution

Department of Pharmacy,Zhujiang Hospital,Southern Medical University

AI问答

Postal code：100700
Tel：010-84076882 Email：syfjx_2010@188.com
Technical support is provided by Beijing Founder electronics co., LTD 京ICP备11006657号-10 京公网安备11010802024621
It is recommended to read the content of this site in Chrome&IE9+. Please switch to extreme mode in browser 360.
Cookies We use cookies to help provide and enhance our service and tailor content. By continuing, you agree to the use of cookies.

⁰