Objective:To optimize molding process of compound Lingdan capsules and establish its standard.Method:Dry granulation technology was adopted

molding technology of compound Lingdan capsules was optimized by single factor test;TLC was used for qualitative identification of Salvia miltiorrhiza and Sophora tonkinensisi;The content of tanshinone IIA and salvianolic acid B was determined by HPLC.Result:The best molding process of compound Lingdan capsules was as following:took prescription amount herbs extracts

added 3% talc

mixed evenly

dry granulating and then filled into 0 capsule.The spots of S.miltiorrhiza and S.tonkinensisi on TLC plates were clear without interference by the blank reference;Anshinone IIA showed a good linear relationship at the range of 0.155-0.003 1 g · L-1

the average recovery was 100.9% with RSD of 1.25%;Salvianolic acid B showed a good linear relationship at the range of 1.750-0.003 5 g·L-1

the average recovery was 101.1% with RSD of 1.25%.Conclusion:This optimized process was simple and stable.This established quality control method was specific and reproducible

which could be applied to quality assessment of compound Lingdan capsules.