Effects of Cuscuta chinensis on Ability of Resistance and Free Radical in Brain Tissue in Exercise-induced Fatigue Rats

GUO Ai-min1; CAO Jian-min2; ZHU Jing1; ZHOU Hai-tao3

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Effects of Cuscuta chinensis on Ability of Resistance and Free Radical in Brain Tissue in Exercise-induced Fatigue Rats

更新时间：2024-09-23

- Effects of Cuscuta chinensis on Ability of Resistance and Free Radical in Brain Tissue in Exercise-induced Fatigue Rats
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 19, Issue 9, Pages: 274-277(2013)
- 作者机构：
  
  1. 中国石油大学
  2. 北京体育大学
  3. 北京联合大学
- 作者简介：
- 基金信息：
- DOI：
  CLC： R285.5
- Published：2013
- 稿件说明：
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[1]郭爱民,曹建民,朱静,周海涛.菟丝子对大鼠抗运动性疲劳能力及脑组织自由基的影响[J].中国实验方剂学杂志,2013,19(09):274-277.

GUO Ai-min1, CAO Jian-min2, ZHU Jing1, et al. Effects of Cuscuta chinensis on Ability of Resistance and Free Radical in Brain Tissue in Exercise-induced Fatigue Rats[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(9): 274-277.
[1]郭爱民,曹建民,朱静,周海涛.菟丝子对大鼠抗运动性疲劳能力及脑组织自由基的影响[J].中国实验方剂学杂志,2013,19(09):274-277. DOI：

GUO Ai-min1, CAO Jian-min2, ZHU Jing1, et al. Effects of Cuscuta chinensis on Ability of Resistance and Free Radical in Brain Tissue in Exercise-induced Fatigue Rats[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(9): 274-277. DOI：

摘要

目的:研究菟丝子对大鼠抗运动性疲劳能力及脑组织自由基的影响。方法:以大强度耐力训练大鼠为模型

65只42 d龄雄性Wistar大鼠为对象

随机分为5组:静止对照组、运动对照组、运动+低剂量菟丝子组、运动+中剂量菟丝子组、运动+高剂量菟丝子组

每组12只。采用专业灌胃器每天灌胃给药（ig）1次。低、中、高剂量组ig剂量分别为1.16

2.32

6.96 g.kg-1.d-1

ig体积为5 mL.kg-1。静止对照组和运动对照组ig等量生理盐水。6周力竭游泳训练。末次训练后24 h

测定体重、力竭游泳时间及脑组织中超氧化物歧化酶（SOD）等与疲劳作用相关的指标。结果:运动+菟丝子各剂量组体重均大于运动对照组（P<0.05）

力竭游泳时间均长于运动对照组（P<0.01）。力竭游泳导致大鼠脑组织中MDA含量显著升高。运动对照组及运动+菟丝子各组分别升高至（6.46±0.21）

（5.17±0.26）

（4.89±0.19）

（4.76±0.33）μmol.L

但运动+菟丝子各组明显低于运动对照组（P<0.01）。SOD

GSH-Px活性显著下降。运动对照组及运动+菟丝子各组SOD分别下降至（207.35±12.27）

（245.85±11.31）

（253.98±11.24）

（261.31±12.69）U.mL-1

GSH-Px分别下降至（52.24±5.35）

（68.57±5.83）

（71.96±5.96）

（73.38±5.15）U.mg-1

但运动+菟丝子各剂量组明显高于运动对照组（P<0.01）。结论:菟丝子具有提高脑组织抗氧化酶活性的作用

从而抑制大强度力竭运动造成的脑组织氧化损伤

延缓疲劳发生。

Abstract

Objective:To study the effects of Cuscuta chinensis on free radical in brain tissue and ability of resistance in exercise-induced fatigue rats.Method: The high-intensity endurance training in rats was used to establish exercise-induced fatigue model.The modeling rats were divided into the 4 groups:model group

low

medium and high groups of C.chinensis group（1.16

2.32

6.96 g · kg-1 · d-1

ig）.Another group without exercise as a control group was set after 6 weeks of exhaustive swimming training.24 h after the last training

weight

exhaustive swimming time and malondialdehyde（MDA）

superoxide dismutase（SOD） and glutathione peroxidase（GSH-Px） in brain were observed.Result: The weight in C.chinensis groups was increased group（P<0.05）

swimming time became longer（P<0.01） compared with model.In C.chinensis groups MDA were decreased compared with model group（P<0.01）

and SOD

GSH-Px activity was significantly increasee.Conclusion: C.chinensis has the antioxidation action and increase ability of resistance on exercise-induced fatigue

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Related Institution

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