Objective:We explore a practical feed formulation in order to establish a stable atherosclerosis animal model.With high fat and hyperhomocysteinemia in shorter period.Method:Forty male SD rats were divided into 4 groups（n=10）

given different formula feeding with common feed

formulationⅠ（not containing propylthiouracil）

formulation II（containing propylthiouracil of 0.15%） and formulation Ⅲ（containing propylthiouracil of 0.25%）.weighed once a week.The blood samples were collected at week 2 and 4 respectively

then to determine the levels of total cholesterol（TC）

low density lipoprotein cholesterin（LDL-C） in serum and homocysteine（Hcy） in plasma.Result: Compared with the control group

weight of formulationⅠhad no significant difference

while weight of formulation II and formulation Ⅲ decreased significantly（P<0.01）;TC

LDL-C and Hcy levels in formulation II and formulation Ⅲ groups increased significantly（P<0.01） at 2

4 weeks

respectively

but formulationⅠhave no significant difference.Conclusion: In this study

we found that the rats fed with the formulation II can establish a stable atherosclerosis animal model with high fat and hyperhomocysteinemia in shorter period.